[Effect of calcium antagonists on ureteral contractile activity in experiment].

Dihydropiridine (nifedipine), phenilalkilamine (isoptin) and a novel domestic calcium channel blocker A-29 were studied for effects on motor activity of an isolated segment of a rabbit ureteral upper-third. Strength of muscular contractions (134 measurements) was evaluated in per cents to the baseline level. Tonic reaction and its duration were measured.

[Pharmacokinetics of hopantenic acid upon peroral administration].

A simple, specific and sensitive RP-HPLC method with UV detection for the determination of hopantenic acid in human blood plasma has been developed. The pharmacokinetics of drug pantocalcin upon single peroral administration was investigated on 18 healthy volunteers. The peak of hopantenic acid in blood plasma was achieved at 1.

[Effect of diumancal, foridon, nifedipine, and verapamil on the myometrium potentials in pregnant rats].

All the preparations under study were i.v. administered to pregnant Wistar rats in the doses adequate to therapeutic those on pregnant woman basis.

[Effect of ryodipine, fenigidin, verapamil, and manganese ions on the contractile strength and the myometrium potential duration during rhythmic stimulation and at rest].

Action of the calcium channels blocking agents was studied using their strong but reversible concentrations, in different regimens. Riodypine and phenihydine suppressed the contraction strength and shortened the AP duration in the myometrium muscle stripes equally effectively both in resting and under stimulation (0.3 Hz).

[Biological effect of laser radiation on the functional state of cardiomyocytes].

Experiments were conducted on Wistar rats to study the effect of laser radiation (LR) with a wavelength of 632.8 and 890.0 nm and power of 0.

[The role of calcium permeability in shaping the level of the local blood supply to the cerebral cortex].

Cerebral blood flow and the water content in the brain cortex were measured in rabbits with indwelling electrodes. Calcium antagonists increased the CBF in the motor area and decreased it in other regions of the brain.