Publications by authors named "D'Vesharronne Moore"
Article Synopsis
- Galectin-3 is a marker linked to heart inflammation and fibrosis, correlating with the severity of heart failure (HF) and potential patient outcomes.
- In a study, plasma levels of galectin-3 were measured in various patients, revealing that higher levels indicate more severe HF and poorer post-surgery survival rates for those with left ventricular assist devices (LVAD).
- After heart transplantation (HTx), galectin-3 levels generally decreased, but higher levels were associated with coronary allograft vasculopathy (CAV), suggesting its potential as a biomarker for monitoring heart health in these patients.
The mammalian heart, the body's largest energy consumer, has evolved robust mechanisms to tightly couple fuel supply with energy demand across a wide range of physiologic and pathophysiologic states, yet, when compared with other organs, relatively little is known about the molecular machinery that directly governs metabolic plasticity in the heart. Although previous studies have defined Kruppel-like factor 15 (KLF15) as a transcriptional repressor of pathologic cardiac hypertrophy, a direct role for the KLF family in cardiac metabolism has not been previously established. We show in human heart samples that KLF15 is induced after birth and reduced in heart failure, a myocardial expression pattern that parallels reliance on lipid oxidation.
View Article and Find Full Text PDFIsoforms of apolipoprotein C-I associated with individuals with coronary artery disease.
Biochem Biophys Res Commun
January 2011
Apolipoprotein C-I (apoC-I) is a 6.6kDa serum protein associated with high density lipoproteins (HDL) and triglyceride-rich lipoproteins. In this study, apoC-I was examined in high density lipoprotein subfractions from individuals with and without coronary artery disease (CAD).
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