Publications by authors named "D'Anne Kudlik"
Multicenter Hemodynamic Assessment of the LOT-CRT Strategy: When Does Combining Left Bundle Branch Pacing and Coronary Venous Pacing Enhance Resynchronization?: Primary Results of the CSPOT Study.
Circ Arrhythm Electrophysiol
November 2024
Article Synopsis
- Left bundle branch area pacing (LBBAP) is being examined as a potential alternative to biventricular pacing (BVP) for patients needing cardiac resynchronization therapy (CRT), with a study comparing the two along with left bundle-optimized therapy CRT (LOT-CRT).
- In the study involving 48 patients, LOT-CRT and BVP showed significantly greater increases in left ventricular pressure and QRS shortening compared to unipolar and bipolar LBBAP, indicating better hemodynamic performance.
- Results also suggested that patients with interventricular conduction delay had less QRS reduction but similar improvements in left ventricular pressure compared to those with left bundle branch block, and the effectiveness of combining LBBAP with coronary vein
Background: The healing response to cardiac implantable electronic device (CIED) implantation results in inflammation that can lead to fibrous pocket formation, which may disrupt pocket healing or complicate future interventions.
Objective: The purpose of this study was to assess CIED pocket healing with use of the second-generation TYRX absorbable antibacterial envelope (T2), the next-generation (NG) TYRX absorbable antibacterial envelope under development, and the CanGaroo® extracellular matrix envelope (ECM) compared to no envelope.
Methods: A total of 110 CIEDs were implanted in an ovine model, either with (T2, NG, or ECM) or without envelopes.
Background: Contemporary Left Ventricular Assist Devices (LVADs) mainly operate at a constant speed, only insufficiently adapting to changes in patient demand. Automatic physiological speed control promises tighter integration of the LVAD into patient physiology, increasing the level of support during activity and decreasing support when it is excessive.
Methods: A sensorless modular control algorithm was developed for a centrifugal LVAD (HVAD, Medtronic plc, MN, USA).
Changes in brain temperature can alter electrical properties of neurons and cause changes in behavior. However, it is not well understood how behaviors, like locomotion, or experimental manipulations, like anesthesia, alter brain temperature. We implanted thermocouples in sensorimotor cortex of mice to understand how cortical temperature was affected by locomotion, as well as by brief and prolonged anesthesia.
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