[Personal experiences of immunotherapy using the transfer factor].

Six subjects, four suffering from chronic mucocutaneous candidosis, one from ataxiatelangiectasia and one from partial combined immunological deficiency with ongoing pulmonary tuberculosis, were treated with transfer factor. The deficient immunological situation normalized in all subjects after treatment. Clinically, all showed improvement excepting one candidosis case.

[Histological and immunological study of patients with lung and digestive tract tumors. Analysis of T and B lymphocytes from the peripheral blood and from the lymph nodes draining the tumor (author's transl)].

The nature of the immune response to the tumor cell is complex and has yet to be clearly defined. Although past research has foscused on the cytotoxic effect of T lymphocytes versus tumor cells, it has been shown in animal studies that B lymphocytes may also be implicated. Lymphocytes from patients with respiratory and digestive tract tumors were studied.

Lymphoid cells in infectious mononucleosis classified according to T and B cell markers.

It has been demonstrated that peripheral blood lymphocytes, particularly the "atypical" ones, are predominantly of the T type in infectious mononucleosis (IM). This is based on membrane marker studies (E rosettes, receptor for complement, receptor for Fc fragment of immunoglobulins (Ig), and membrane Ig) and by anti-T lymphocyte serum. On the other hand, lymphoblastoid cell lines derived from IM patients show the characteristics of B lymphocytes.

Surface markers on human lymphocytes: studies of normal subjects and of patients with primary immunodeficiencies.

Peripheral blood lymphocytes of twenty normal controls and twelve patients with primary immunodeficiencies were examined for surface membrane Ig and receptors for C3 complement (B cell markers) and for spontaneous rosette formation with sheep erythrocytes (T cell markers). In patients with defects in T cell function no lymphocytes forming spontaneous rosettes were seen. In patients with B cell deficiency they were normal or increased.

Surface markers on lymphocytes of patients with infectious diseases.

PERIPHERAL BLOOD LYMPHOCYTES FROM NORMAL SUBJECTS AND PATIENTS WITH VIRAL AND BACTERIAL INFECTIOUS DISEASES WERE EXAMINED FOR THE PRESENCE OF THREE SURFACE MARKERS: (i) surface immunoglobulins, (ii) receptor for C3 complement component (EAC test), and (iii) spontaneous binding of sheep red blood cells (E rosette formation). The first two markers are used to detect bone marrow-derived lymphocytes (B cells); the E rosette formation is dependent on thymus-derived lymphocytes (T cells). We demonstrated these assumptions, as defined by others, by the fractionation of lymphocytes on bead columns coated with immunoglobulin plus anti-immunoglobulin.