Publications by authors named "Cyrus Amirfazli"

Quantitative MRI biomarkers are sought to replace painful and invasive sequential bone-marrow biopsies routinely used for myelofibrosis (MF) cancer monitoring and treatment assessment. Repeatability of MRI-based quantitative imaging biomarker (QIB) measurements was investigated for apparent diffusion coefficient (ADC), proton density fat fraction (PDFF), and magnetization transfer ratio (MTR) in a JAK2 V617F hematopoietic transplant model of MF. Repeatability coefficients (RCs) were determined for three defined tibia bone-marrow sections (2-9 mm; 10-12 mm; and 12.

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Article Synopsis
  • Cancer treatments often require combination therapies, which can lead to toxic side effects.
  • A new drug, LP-182, effectively targets key cancer pathways without causing noticeable toxicity, thanks to its unique ability to be absorbed through the lymphatic system.
  • Studies show that LP-182 can reduce disease symptoms and improve survival rates in animal models, paving the way for better treatments that utilize lymphatic drug absorption.
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