Oxidized LDL regulates efferocytosis through the CD36-PKM2-mtROS pathway.

Unlabelled: Macrophage efferocytosis, the process by which phagocytes engulf and remove apoptotic cells (ACs), plays a critical role in maintaining tissue homeostasis. Efficient efferocytosis prevents secondary necrosis, mitigates chronic inflammation, and impedes atherosclerosis progression. However, the regulatory mechanisms of efferocytosis under atherogenic conditions remain poorly understood.

Neural stem cells characterization in the vagal complex of adult ovine brain: A combined neurosphere assay/RTqPCR approach.

Neural stem cells are the effectors of adult neurogenesis, which occurs in discrete restricted areas of adult mammalian brain. In ovine species, like in rodents, in vivo incorporation of labeled DNA precursor led to characterize neurogenic proliferation in the subventricular zone and progeny migration and differentiation into the olfactory bulb. The present study addresses directly the existence of neural stem cells in the neurogenic niche of the vagal centre (area postrema) by in vitro neurosphere assay and RT-qPCR of specific markers on ex-vivo adult tissue explants, comparatively with the canonical neurogenic niche: the subventricular zone (SVZ) of the forebrain.

Neural stem cell self-renewal stimulation by store-operated calcium entries in adult mouse area postrema: influence of leptin.

Neural stem cells (NSCs) persist in specific brain germinative niches and sustain neurogenesis throughout life in adult mammals. In addition to the two major stem cell niches in the subventricular zone and the hippocampal dentate gyrus, the area postrema located in the brainstem has been identified as a neurogenic zone as well. NSCs are regulated by signals from the microenvironment that adjust stem cell response to the needs of the organism.

CCRL2 Modulates Physiological and Pathological Angiogenesis During Retinal Development.

Chemerin is a multifunctional protein involved in the regulation of inflammation, metabolism, and tumorigenesis. It binds to three receptors, CMKLR1, GPR1 and CCRL2. CMKLR1 is a fully functional receptor mediating most of the known activities of chemerin.

Chemerin regulates normal angiogenesis and hypoxia-driven neovascularization.

Chemerin is a multifunctional protein initially characterized in our laboratory as a chemoattractant factor for leukocyte populations. Its main functional receptor is CMKLR1. We identified previously chemerin as an anti-tumoral factor inhibiting the vascularization of tumor grafts.

Dual enkephalinase inhibitor PL265: a novel topical treatment to alleviate corneal pain and inflammation.

Ocular pain is a core symptom of inflammatory or traumatic disorders affecting the anterior segment. To date, the management of chronic ocular pain remains a therapeutic challenge in ophthalmology. The main endogenous opioids (enkephalins) play a key role in pain control but exhibit only transient analgesic effects due to their rapid degradation.