Publications by authors named "Cyril Nerin"
Since the first genome-wide association studies (GWASs), thousands of variant-trait associations have been discovered. However, comprehensively mapping the genetic determinant of complex traits through univariate testing can require prohibitive sample sizes. Multi-trait GWAS can circumvent this issue and improve statistical power by leveraging the joint genetic architecture of human phenotypes.
View Article and Find Full Text PDFSince the first Genome-Wide Association Studies (GWAS), thousands of variant-trait associations have been discovered. However, the sample size required to detect additional variants using standard univariate association screening is increasingly prohibitive. Multi-trait GWAS offers a relevant alternative: it can improve statistical power and lead to new insights about gene function and the joint genetic architecture of human phenotypes.
View Article and Find Full Text PDFArticle Synopsis
- Genome-wide association studies (GWAS) have identified connections between common genetic variants and various human traits across 36 different phenotypes.
- This study combines multitrait association mapping with an analysis of genetic variant clusters to understand their genetic architecture and biological implications.
- The research specifically highlights how these genetic variants relate to immune responses and metabolism, examining their roles in biological pathways and the effectiveness of drug targets in clinical trials.