Lipoprotein DolP supports proper folding of BamA in the bacterial outer membrane promoting fitness upon envelope stress.

In Proteobacteria, integral outer membrane proteins (OMPs) are crucial for the maintenance of the envelope permeability barrier to some antibiotics and detergents. In Enterobacteria, envelope stress caused by unfolded OMPs activates the sigmaE (σ) transcriptional response. σ upregulates OMP biogenesis factors, including the β-barrel assembly machinery (BAM) that catalyses OMP folding.

Transmembrane Coordination of Preprotein Recognition and Motor Coupling by the Mitochondrial Presequence Receptor Tim50.

Mitochondrial preproteins contain amino-terminal presequences directing them to the presequence translocase of the mitochondrial inner membrane (TIM23 complex). Depending on additional downstream import signals, TIM23 either inserts preproteins into the inner membrane or translocates them into the matrix. Matrix import requires the coupling of the presequence translocase-associated motor (PAM) to TIM23.

Mitochondrial presequence import: Multiple regulatory knobs fine-tune mitochondrial biogenesis and homeostasis.

Mitochondria are pivotal organelles for cellular signaling and metabolism, and their dysfunction leads to severe cellular stress. About 60-70% of the mitochondrial proteome consists of preproteins synthesized in the cytosol with an amino-terminal cleavable presequence targeting signal. The TIM23 complex transports presequence signals towards the mitochondrial matrix.

Use of a neuro-variational inversion for retrieving oceanic and atmospheric constituents from satellite ocean colour sensor: application to absorbing aerosols.

This paper presents a new development of the NeuroVaria method. NeuroVaria computes relevant atmospheric and oceanic parameters by minimizing the difference between the observed satellite reflectances and those computed from radiative transfer simulations modelled by artificial neural networks. Aerosol optical properties are computed using the Junge size distribution allowing taking into account highly absorbing aerosols.

A home blood pressure monitoring study comparing the antihypertensive efficacy of two angiotensin II receptor antagonist fixed combinations.

Background: The objective of this prospective, randomized, open-label, blinded-endpoint study was to compare the antihypertensive efficacy of valsartan 80 mg v irbesartan 150 mg when combined with hydrochlorothiazide (HCTZ) 12.5 mg.

Methods: Untreated or uncontrolled hypertensive adults (n = 800) were enrolled by primary care physicians.