Publications by authors named "Cyrielle Codde"
Background And Objective: The dosage of daptomycin is usually based on body weight. However, it has been shown that this approach yields too high an exposure in obese patients. Pharmacokinetic and pharmacodynamic indexes (PK/PD) have been proposed for daptomycin's antibacterial effect (AUC/CMI >666) and toxicity (C0 > 24.
View Article and Find Full Text PDFDaptomycin is a concentration-dependent lipopeptide antibiotic for which exposure/effect relationships have been shown. Machine learning (ML) algorithms, developed to predict the individual exposure to drugs, have shown very good performances in comparison to maximum a posteriori Bayesian estimation (MAP-BE). The aim of this work was to predict the area under the blood concentration curve (AUC) of daptomycin from two samples and a few covariates using XGBoost ML algorithm trained on Monte Carlo simulations.
View Article and Find Full Text PDFBackground: This study aimed to evaluate the concentrations of rilpivirine (RLP) and doravirine (DOR) after 3 days-off using simulations from population pharmacokinetics models.
Methods: The authors conducted a series of 500 sets of 10,000 Monte Carlo simulations to examine the steady-state conditions for 2 common dosage levels: 25 mg/d for RLP and 100 mg/d for DOR. These simulations were conducted under 2 scenarios: 1 without drug cessation and another after a 3-day break.
The incidence of campylobacteriosis has substantially increased over the past decade, notably in France. Secondary localizations complicating invasive infections are poorly described. We aimed to describe vascular infection or endocarditis caused by Campylobacter spp.
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- A 66-year-old male patient with chronic renal failure was treated with doravirine for HIV-1 while undergoing hemodialysis three times a week.
- The study found that hemodialysis caused a significant average decrease of 48.1% in doravirine concentration, which was unexpected as previous understanding suggested minimal impact.
- The authors recommend therapeutic drug monitoring for patients on doravirine who are also on hemodialysis due to the considerable concentration drop, even though adjustments to the dose are not necessary since levels remained above the effective range.
Article Synopsis
- Enterococcus faecalis infective endocarditis (EFIE) has a higher relapse rate compared to other types of infective endocarditis, and this study explores the influence of different antibiotic treatments on these relapses.
- The research involved 279 patients from 14 hospitals in France, analyzing the occurrence of relapses within one year following diagnosis, using specific statistical models to account for competing risks like death.
- Results showed that relapses are common (9.3% in one year) and can even be asymptomatic, with surgery during treatment noted as a protective factor; the relapse rates varied significantly based on the type of antibiotic regimen used.
Due to their rapid evolution and their impact on healthcare, beta-lactamases, protein degrading beta-lactam antibiotics, are used as generic models of protein evolution. Therefore, we investigated the mutation effects in two distant beta-lactamases, TEM-1 and CTX-M-15. Interestingly, we found a site with a complex pattern of genetic interactions.
View Article and Find Full Text PDFBackground: Campylobacter spp. bacteremia is a severe infection. A nationwide 5-year retrospective study was conducted to characterize its clinical features and prognostic factors.
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