Clinical features of precursor-targeted immune-mediated anemia in dogs: 66 cases (2004-2013).

Objective: To characterize the clinical features of dogs with precursor-targeted immune-mediated anemia (PIMA).

Animals: 66 dogs with PIMA.

Procedures: Electronic record databases of a teaching hospital were searched to identify dogs with a diagnosis of nonregenerative anemia between 2004 and 2013.

Histologic and cytologic bone marrow findings in dogs with suspected precursor-targeted immune-mediated anemia and associated phagocytosis of erythroid precursors.

Background: Precursor-targeted immune-mediated anemia (PIMA) has been suspected in dogs with nonregenerative anemia and bone marrow findings varying from erythroid hyperplasia to pure red cell aplasia. Phagocytosis of erythroid precursors/rubriphagocytosis (RP) reported in some affected dogs suggests a destructive component to the pathogenesis of PIMA.

Objectives: The purpose of the study was to characterize laboratory and clinical findings in dogs with suspected PIMA and RP, with emphasis on cytologic and histologic bone marrow findings.

Flow cytometric assessment of canine erythrocytes and platelets for dog erythrocyte antigen 1.1.

Background: In human medicine, transfusion of ABO-mismatched platelets has been associated with shortened platelet survival and refractoriness to platelet transfusion because of expression of certain blood group antigens on platelets. It remains unknown if canine platelets express dog erythrocyte antigens (DEAs).

Objective: The aim of this study was to develop a flow cytometric assay for DEA 1.