Publications by authors named "Cynthia Taub"

Article Synopsis
  • Left bundle branch block (LBBB) is a common heart condition that raises concerns about its link to cardiomyopathy and specifically how it might initiate dilated cardiomyopathy.
  • The study involved inducing LBBB in 14 dogs, monitoring their heart function and structural changes at multiple time points to understand the effects on left ventricular function and potential pathological mechanisms.
  • Results showed that LBBB caused significant heart tissue damage and progressive left ventricular dysfunction over 12 months, revealing a complex relationship between LBBB and cardiomyopathy that could guide future clinical research and treatments.
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A 37-year-old gravida 5, para 3 woman presented with an unplanned pregnancy 6 weeks after experiencing a cardiac arrest caused by ventricular fibrillation from coronary vasospasm. She opted to continue the pregnancy with medical management despite ongoing chest pain and delivered a healthy female infant via vaginal delivery at 37 weeks.

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• Pericardial paragangliomas can present with angina and dyspnea. • TTE is often the first-line test for assessing pericardial tumors. • Long sweeps and contrast enhancement may enhance visualization of pericardial masses.

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A major manifestation of Friedreich ataxia (FRDA) is cardiomyopathy, caused by mitochondrial proliferation in myocytes. Because the lifespan for patients with FRDA improves with better treatment modalities, more patients are becoming pregnant, meaning that more medical providers must know how to care for this population. This report provides a review of the literature on multidisciplinary management of pregnant patients with FRDA and cardiomyopathy from preconception through lactation.

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Stress echocardiography is a diagnostic cardiovascular exam that is commonly utilized for multiple indications, including but not limited to the assessment of obstructive coronary artery disease, valvular disease, obstructive hypertrophic cardiomyopathy, and diastolic function. Stress echocardiography can be performed via both exercise and pharmacologic modalities. Exercise stress is performed with either treadmill or bicycle-based exercise.

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• Foreign substances can interfere with the TEE probe, causing poor image quality. • Operators should be aware of the reasons for diffusely anechoic TEE images. • Poor identification of echocardiographic artifacts may lead to adverse outcomes.

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Purpose: To evaluate the safety, efficacy, and outcomes of outpatient intravenous diuresis in a rural setting and compare it to urban outcomes.

Methods: A single-center study was conducted on 60 patients (131 visits) at the Dartmouth-Hitchcock Medical Center (DHMC) from 1/2021-12/2022. Demographics, visit data, and outcomes were collected and compared to urban outpatient IV centers, and inpatient HF hospitalizations from DHMC FY21 and national means.

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Importance: During the first year of the COVID-19 pandemic, there was a substantial increase in the rate of death in the United States. It is unclear whether those who had access to comprehensive medical care through the Department of Veterans Affairs (VA) health care system had different death rates compared with the overall US population.

Objective: To quantify and compare the increase in death rates during the first year of the COVID-19 pandemic between individuals who received comprehensive medical care through the VA health care system and those in the general US population.

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Article Synopsis
  • This study aimed to compare health care usage, treatment, and mortality rates between rural and urban patients with congestive heart failure (CHF) using data from the Veterans Health Administration.
  • The analysis included patients categorized by heart function, and results showed that one-third of patients lived in rural areas, with rural patients using VHA facilities similarly or less for certain outpatient services.
  • Overall, there were no significant differences in treatment rates or mortality between rural and urban patients, indicating that the VHA may have successfully reduced typical disparities in access and health outcomes for rural CHF patients.
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Maternal mortality in the United States is a public health crisis of preventable deaths among young women. The role of echocardiography in the evaluation of pregnant women with cardiovascular symptoms or risk factors without known heart disease is unclear. We retrospectively examined the clinical characteristics of consecutive pregnant patients without established heart disease who underwent echocardiography and evaluated associations between abnormal exam findings and obstetric outcomes.

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Objective: Echocardiography-guided Percutaneous IntraMyocardial Septal Radiofrequency Ablation (PIMSRA, Liwen procedure) is a novel treatment option for hypertrophic obstructive cardiomyopathy (HOCM). The impact of PIMSRA on myocardial mechanics is unknown.

Methods: Between October 2016 and June 2019, PIMSRA and 3-dimentional speckle tracking echocardiography were performed in 82 patients.

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Article Synopsis
  • This study examined the cardiovascular health of women with HIV compared to those without, focusing on various heart conditions using echocardiography in the Women's Interagency HIV Study.
  • Of the 1,654 participants, about 70% had HIV, with findings revealing a higher risk of left ventricular systolic dysfunction (LVSD) in women with HIV, particularly as their CD4+ count decreased.
  • The results suggest that while women with HIV do have an increased risk for certain heart issues, especially at lower immune cell counts, it emphasizes the need for both heart health monitoring and HIV management in this population.
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Introduction: Accurate assessment of right ventricular (RV) systolic function has prognostic and therapeutic implications in many disease states. Echocardiography remains the most frequently deployed imaging modality for this purpose, but estimation of RV systolic function remains challenging. The purpose of this study was to evaluate the diagnostic performance of a novel measurement of RV systolic function called lateral annular systolic excursion ratio (LASER), which is the fractional shortening of the lateral tricuspid annulus to apex distance, compared to right ventricular ejection fraction (RVEF) derived by cardiac magnetic resonance imaging (CMR).

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Transgender individuals are increasingly seeking the care of physicians to physically transition to their self-identified gender identity. Gender-affirming hormone therapy (GAHT) has significant endocrine effects which may have cardiovascular consequences, and cardiovascular disease in transgender individuals is a growing area of study. The effects of GAHT on cardiac mechanics have yet to be characterized, but there is existing literature regarding changes to cardiac mechanics in similar altered hormonal states.

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We aim to explore patterns of inpatient code status during the COVID-19 pandemic compared with a similar timeframe the previous year, as well as utilization of palliative care services. This is a retrospective cohort study using data from the Montefiore Health system of all inpatient admissions between March 15-May 31, 2019 and March 15-May 31, 2020. Univariate logistic regression was performed with full code status as the outcome.

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Point-of-care ultrasonography (POCUS) refers to limited bedside ultrasound used to evaluate patients for conditions specific to the scope of their practice. Given the benefits of its application, interest in its use is increasing. We aimed to review the literature and assess the potential feasibility of using POCUS of the heart and lungs in the field of obstetrics.

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Article Synopsis
  • Functional mitral regurgitation (FMR) is a common issue in patients with acute decompensated heart failure and significantly affects outcomes such as mortality and hospitalization rates.
  • A study reviewed data from 2,303 patients, finding that over half had at least moderate FMR, which was linked to a higher risk of 1-year all-cause mortality and increased readmissions within 6 months.
  • The findings suggest that better follow-up care and targeted treatments for FMR are needed, especially considering potential differences in severity based on sex.
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In the strictest sense, do-not-resuscitate (DNR) status means that cardiopulmonary resuscitation should not be performed after death has occurred; all other medical interventions in line with a patient's goals of care should be implemented. The use of transthoracic echocardiography (TTE) in patients with DNR status is unknown. Therefore, we aim to evaluate the utilization of TTE among patients with DNR status using this retrospective data analysis.

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Article Synopsis
  • Limited effective treatments for heart failure with preserved ejection fraction (HFpEF) exist, but SGLT2 inhibitors (SGLT2i) may enhance outcomes for patients with systolic heart failure and type-2 diabetes.
  • A study involving 250 patients compared those taking SGLT2i to those on sitagliptin, focusing on heart failure hospitalizations, overall hospitalizations, and acute kidney injury.
  • Results showed that SGLT2i significantly reduced the risk of heart failure hospitalizations, overall hospitalizations, and acute kidney injury compared to sitagliptin.
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Background: Whether the combination of ventricular strain with high-sensitivity troponin I (hs-TNI) has an incremental prognostic value in coronavirus disease 2019 (COVID-19) patients has not been evaluated. The study aimed to evaluate the prognostic value of biventricular longitudinal strain and its combination with hs-TNI in COVID-19 patients.

Methods: A total of 160 COVID-19 patients who underwent both echocardiography and hs-TNI testing were enrolled in our study.

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Article Synopsis
  • This study examined the effectiveness of high frame rate speckle-tracking echocardiography (STE) at around 200 fps compared to the conventional rate of about 50 fps in patients with normal heart function.
  • Results showed that using the higher frame rate (rHi-FR) resulted in significantly higher absolute strain values than the traditional frame rate (Reg-FR), with strong agreement in measurements between different observers.
  • The findings suggest that improved temporal resolution of rHi-FR allows for more accurate measurements of myocardial strain, though further research is needed to explore its usefulness in conditions like tachycardia.
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