Publications by authors named "Cynthia N Prudence"
Parking problem and negative cooperativity of binding of myosin subfragment 1 to F-actin.
Biochem Biophys Res Commun
September 2012
Article Synopsis
- Myosin subfragment 1 (S1) can bind to one or two actin monomers, with its binding state influenced by the concentration of S1 relative to actin.
- A study using fluorescently labeled F-actin showed that the transition from binding one actin to two depends on the availability of free actin, which is higher when the S1 to actin ratio is less than 0.5 and decreases significantly when it exceeds 2.0.
- The findings suggest that the sequential binding of S1 to actin is crucial for generating force and facilitating movement in muscle cells.