Publications by authors named "Cynthia J Willey"
Autosomal dominant polycystic kidney disease (ADPKD) is a genetic kidney disease with high phenotypic variability. Furthering insights into patients' ADPKD progression could lead to earlier detection, management, and alter the course to end stage kidney disease (ESKD). We sought to identify patients with rapid decline (RD) in kidney function and to determine clinical factors associated with RD using a data-driven approach.
View Article and Find Full Text PDFBackground: This study aimed to determine the incidence and prevalence of immunoglobulin A nephropathy (IgAN) in Europe based on high-quality data from national registries.
Methods: IgAN incidences were obtained from a literature review of European studies of national kidney biopsy registry data in which IgAN diagnosis was biopsy-verified using contemporary techniques. Studies were eligible for the main analysis if published from 1990 to 2020.
Rationale & Objective: Understanding potential differences in patterns of kidney failure among patients with autosomal dominant polycystic kidney disease (ADPKD) may provide insights into improving disease management. We sought to characterize patients with ADPKD and kidney failure across different race/ethnicities.
Study Design: Cross-sectional study.
Background: Dementia patients frequently depend on caregivers. Agitation is a common behavioral dementia symptom particularly burdensome to patients and caregivers.
Objective: To assess the association of agitation severity with non-professional caregiver hours, burden, health status, and productivity.
Among a large racially and ethnically diverse US population, the prevalence of diagnosed ADPKD between 2002 and 2018 was 42.6 per 100,000 persons.ADPKD prevalence (per 100,000) was higher in (non-Hispanic) White (63.
View Article and Find Full Text PDFBackground: Cardiovascular disease (CVD) is the most prevalent comorbidity for chronic obstructive pulmonary disease (COPD). Potential adverse cardiovascular events of bronchodilators warrant their cautionary use in the comorbid COPD-CVD population, yet little is known about the prescribing of bronchodilators in this high-risk patient group.
Objective: To determine whether comorbid CVD is associated with reduced bronchodilator prescribing in patients with COPD.
Prevalence of autosomal dominant polycystic kidney disease in the European Union.
Nephrol Dial Transplant
August 2017
Article Synopsis
- Autosomal dominant polycystic kidney disease (ADPKD) is a significant cause of end-stage renal disease, with its prevalence estimates varying widely across studies.
- A systematic review of studies from 1980 to 2015 analyzed the prevalence of ADPKD in large German and British populations to derive minimum and screening prevalence estimates.
- The findings revealed a minimum prevalence between 2.41 and 3.89 per 10,000 individuals, and suggests that if widespread screening were adopted, the prevalence could rise to approximately 3.96 per 10,000 in the EU, confirming that ADPKD is considered a rare disease (under 5 per 10,000).
Objective: To evaluate antidiabetic drug treatment patterns and glycemic control among patients diagnosed with type 2 diabetes mellitus.
Study Design: Retrospective study using the automated databases of a 200 000-member HMO.
Methods: The study population consisted of patients > or =18 years of age with documented type 2 diabetes mellitus from January 1, 2002, through December 31, 2002.