Publications by authors named "Cynthia C Taub"

Article Synopsis
  • Left bundle branch block (LBBB) is a common heart condition that raises concerns about its link to cardiomyopathy and specifically how it might initiate dilated cardiomyopathy.
  • The study involved inducing LBBB in 14 dogs, monitoring their heart function and structural changes at multiple time points to understand the effects on left ventricular function and potential pathological mechanisms.
  • Results showed that LBBB caused significant heart tissue damage and progressive left ventricular dysfunction over 12 months, revealing a complex relationship between LBBB and cardiomyopathy that could guide future clinical research and treatments.
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A 37-year-old gravida 5, para 3 woman presented with an unplanned pregnancy 6 weeks after experiencing a cardiac arrest caused by ventricular fibrillation from coronary vasospasm. She opted to continue the pregnancy with medical management despite ongoing chest pain and delivered a healthy female infant via vaginal delivery at 37 weeks.

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A major manifestation of Friedreich ataxia (FRDA) is cardiomyopathy, caused by mitochondrial proliferation in myocytes. Because the lifespan for patients with FRDA improves with better treatment modalities, more patients are becoming pregnant, meaning that more medical providers must know how to care for this population. This report provides a review of the literature on multidisciplinary management of pregnant patients with FRDA and cardiomyopathy from preconception through lactation.

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Purpose: To evaluate the safety, efficacy, and outcomes of outpatient intravenous diuresis in a rural setting and compare it to urban outcomes.

Methods: A single-center study was conducted on 60 patients (131 visits) at the Dartmouth-Hitchcock Medical Center (DHMC) from 1/2021-12/2022. Demographics, visit data, and outcomes were collected and compared to urban outpatient IV centers, and inpatient HF hospitalizations from DHMC FY21 and national means.

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Maternal mortality in the United States is a public health crisis of preventable deaths among young women. The role of echocardiography in the evaluation of pregnant women with cardiovascular symptoms or risk factors without known heart disease is unclear. We retrospectively examined the clinical characteristics of consecutive pregnant patients without established heart disease who underwent echocardiography and evaluated associations between abnormal exam findings and obstetric outcomes.

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Objective: Echocardiography-guided Percutaneous IntraMyocardial Septal Radiofrequency Ablation (PIMSRA, Liwen procedure) is a novel treatment option for hypertrophic obstructive cardiomyopathy (HOCM). The impact of PIMSRA on myocardial mechanics is unknown.

Methods: Between October 2016 and June 2019, PIMSRA and 3-dimentional speckle tracking echocardiography were performed in 82 patients.

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Article Synopsis
  • This study examined the cardiovascular health of women with HIV compared to those without, focusing on various heart conditions using echocardiography in the Women's Interagency HIV Study.
  • Of the 1,654 participants, about 70% had HIV, with findings revealing a higher risk of left ventricular systolic dysfunction (LVSD) in women with HIV, particularly as their CD4+ count decreased.
  • The results suggest that while women with HIV do have an increased risk for certain heart issues, especially at lower immune cell counts, it emphasizes the need for both heart health monitoring and HIV management in this population.
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Introduction: Accurate assessment of right ventricular (RV) systolic function has prognostic and therapeutic implications in many disease states. Echocardiography remains the most frequently deployed imaging modality for this purpose, but estimation of RV systolic function remains challenging. The purpose of this study was to evaluate the diagnostic performance of a novel measurement of RV systolic function called lateral annular systolic excursion ratio (LASER), which is the fractional shortening of the lateral tricuspid annulus to apex distance, compared to right ventricular ejection fraction (RVEF) derived by cardiac magnetic resonance imaging (CMR).

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We aim to explore patterns of inpatient code status during the COVID-19 pandemic compared with a similar timeframe the previous year, as well as utilization of palliative care services. This is a retrospective cohort study using data from the Montefiore Health system of all inpatient admissions between March 15-May 31, 2019 and March 15-May 31, 2020. Univariate logistic regression was performed with full code status as the outcome.

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Point-of-care ultrasonography (POCUS) refers to limited bedside ultrasound used to evaluate patients for conditions specific to the scope of their practice. Given the benefits of its application, interest in its use is increasing. We aimed to review the literature and assess the potential feasibility of using POCUS of the heart and lungs in the field of obstetrics.

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In the strictest sense, do-not-resuscitate (DNR) status means that cardiopulmonary resuscitation should not be performed after death has occurred; all other medical interventions in line with a patient's goals of care should be implemented. The use of transthoracic echocardiography (TTE) in patients with DNR status is unknown. Therefore, we aim to evaluate the utilization of TTE among patients with DNR status using this retrospective data analysis.

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Article Synopsis
  • Limited effective treatments for heart failure with preserved ejection fraction (HFpEF) exist, but SGLT2 inhibitors (SGLT2i) may enhance outcomes for patients with systolic heart failure and type-2 diabetes.
  • A study involving 250 patients compared those taking SGLT2i to those on sitagliptin, focusing on heart failure hospitalizations, overall hospitalizations, and acute kidney injury.
  • Results showed that SGLT2i significantly reduced the risk of heart failure hospitalizations, overall hospitalizations, and acute kidney injury compared to sitagliptin.
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Background: Whether the combination of ventricular strain with high-sensitivity troponin I (hs-TNI) has an incremental prognostic value in coronavirus disease 2019 (COVID-19) patients has not been evaluated. The study aimed to evaluate the prognostic value of biventricular longitudinal strain and its combination with hs-TNI in COVID-19 patients.

Methods: A total of 160 COVID-19 patients who underwent both echocardiography and hs-TNI testing were enrolled in our study.

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The accuracy of speckle-tracking echocardiography (STE) depends on temporal resolution. The goal of this study was to demonstrate the feasibility of relatively high frame rate (rHi-FR) (~200 fps) for STE. In this prospective study, echocardiographic images were acquired using clinical scanners on patients with normal left ventricular systolic function using rHi-FR and conventional frame rate (Reg-FR) (~50 FPS).

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• Congenital heart disease may be first diagnosed during pregnancy. • PDA with significant left-to-right shunting can cause peripartum cardiac decompensation. • Multidisciplinary management of congenital heart disease in pregnancy is recommended.

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(1) Background: This study sought to explore how the novel coronavirus (COVID-19) pandemic affected the echocardiography (TTE) laboratory operations at a high volume medical center in New York City. Changes in cardiac imaging study volume, turn-around time, and abnormal findings were analyzed and compared to a pre-pandemic period. (2) Methods: Volume of all cardiac imaging studies and TTE reports between 11 March 2020 to 5 May 2020 and the same calendar period in 2019 were retrospectively identified and compared.

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Article Synopsis
  • A significant number of patients who experience acute myocardial infarction go on to develop heart failure, creating a major healthcare challenge.
  • Changes in heart cell structure due to chronic coronary artery disease can lead to lasting damage and increased risk of ischemic cardiomyopathy.
  • Recent clinical trials question the effectiveness of existing imaging techniques for guiding coronary bypass surgery, suggesting that advancements in medical therapies may diminish the role of myocardial viability imaging in improving patient outcomes.
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We present a late presentation of saddle pulmonary embolism and thrombus-in-transit straddle the patent foramen on patient who successfully recovered from severe acute respiratory syndrome coronavirus-2 (COVID-19) pneumonia. Seven days postdischarge (ie, 28 days after initial COVID-19 symptom onset), she was readmitted to hospital for severe dyspnea. Computer tomography angiogram and echocardiography confirmed the diagnosis.

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A 34-year-old Hispanic man sustained a stab wound to his chest complicated with hemopericardium and pericardial tamponade. He underwent emergent clamshell thoracotomy as well as repair to the pulmonary artery. A transthoracic echocardiogram showed no evidence of intracardiac shunt.

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Background: Information on the clinical and echocardiographic characteristics of young patients with heart failure with reduced ejection fraction is scant, especially among racially diverse populations.

Methods: Patients admitted to Montefiore Medical Center between 2000 and 2016 with heart failure and ejection fraction of <40% were categorized as young (18-39 years), middle-aged (40-64 years), and elderly (≥65 years). Multivariable Cox regression models were used to evaluate mortality risk.

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Objectives: We aimed to study the racial differences in clinical presentations, survival outcomes and outcome predictors among patients with heart failure (HF) with midrange ejection fraction (HFmrEF, EF 40%-49%).

Design: This is a retrospective study.

Setting: Adults with HF diagnosis at Montefiore Medical Center, Bronx, New York between 2008 and 2012, with an inpatient echocardiogram showing left ventricular ejection fraction of 40%-49% were included as HFmrEF population.

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