The expression pattern of N-acetyltransferase 1 in healthy human skin.

Background: N-acetyltransferase 1 (NAT1) is an enzyme expressed among others in keratinocytes in human skin. NAT1 is important in the biotransformation of aromatic amines, an important example being p-phenylenediamine (PPD), a hair dye molecule. Unoxidized PPD penetrates the skin and is N-acetylated by NAT1.

Skin exposure to scented products used in daily life and fragrance contact allergy in the European general population - The EDEN Fragrance Study.

Background: Fragrances are widely used in scented products used in daily life with the potential to induce skin sensitization.

Objective: To evaluate exposure to scented products and to explore associations between exposure and fragrance contact allergy.

Methods: A cross-sectional study on individuals from 18 to 74 years of age, who were randomly selected from the general population in five European countries.

Dupilumab is very effective in a large cohort of difficult-to-treat adult atopic dermatitis patients: First clinical and biomarker results from the BioDay registry.

Introduction: Dupilumab has recently been approved for the treatment of moderate to severe atopic dermatitis (AD) in adults. Daily practice data on dupilumab treatment are scarce.

Objective: To study the effect of 16-week treatment with dupilumab on clinical response and serum biomarkers in adult patients with moderate-severe AD in daily practice.

Allergic contact dermatitis caused by 1,6-hexanediol diacrylate in a hospital wristband.

Background: 1,6-Hexanediol diacrylate (1,6-HDDA) is a multifunctional acrylate and a potent sensitizer.

Objectives: To report a case of allergic contact dermatitis caused by 1,6-HDDA in a hospital wristband.

Methods: A male patient presented with eczema on his wrist where he had worn a hospital wristband.

New positive patch test reactions on day 7-The additional value of the day 7 patch test reading.

Background: Not performing a day (D) 7 patch test reading might result in positive patch test reactions being missed.

Objectives: To investigate the added value of the D7 patch test reading for individual allergens, and to identify patient characteristics and allergen groups associated with new positive D7 reactions.

Methods: Data from patients patch tested between 2008 and 2018 with the extended European baseline series were analysed.