Survival After Severe COVID-19: Long-Term Outcomes of Patients Admitted to an Intensive Care Unit.

Background: Understanding the long-term sequelae of severe COVID-19 remains limited, particularly in the United States.

Objective: To examine long-term outcomes of patients who required intensive care unit (ICU) admission for severe COVID-19.

Design, Patients, And Main Measures: This is a prospective cohort study of patients who had severe COVID-19 requiring an ICU admission in a two-hospital academic health system in Southern California.

Alternate sigma factor RpoS is required for the in vivo-specific repression of Borrelia burgdorferi plasmid lp54-borne ospA and lp6.6 genes.

While numerous positively regulated loci have been characterized during the enzootic cycle of Borrelia burgdorferi, very little is known about the mechanism(s) involved in the repression of borrelial loci either during tick feeding or within the mammalian host. Here, we report that the alternative sigma factor RpoS is required for the in vivo-specific repression of at least two RpoD-dependent B. burgdorferi loci, ospA and lp6.