Publications by authors named "Cyndi G Geoghegan"
Sepsis is a clinical syndrome of life-threatening organ dysfunction caused by a dysregulated response to infection, for which disease heterogeneity is a major obstacle to developing targeted treatments. We have previously identified gene-expression-based patient subgroups (sepsis response signatures [SRS]) informative for outcome and underlying pathophysiology. Here, we aimed to investigate the role of genetic variation in determining the host transcriptomic response and to delineate regulatory networks underlying SRS.
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- - Sepsis is a severe response to infection that causes life-threatening organ dysfunction, highlighting the need for better understanding and new treatments for this global health issue.
- - Researchers utilized high-throughput tandem mass spectrometry to analyze the plasma proteins of sepsis patients compared to other groups, collecting extensive data from over 2,600 samples to identify specific protein changes and disease features.
- - The findings offer insights into the immune response to sepsis, helping to pinpoint subtypes of the condition, potential biomarkers for diagnosis, and paving the way for personalized treatment strategies.
Objective: To describe immune pathways and gene networks altered following major abdominal surgery and to identify transcriptomic patterns associated with postoperative pneumonia.
Background: Nosocomial infections are a major healthcare challenge, developing in over 20% of patients aged 45 or over undergoing major abdominal surgery, with postoperative pneumonia associated with an almost 5-fold increase in 30-day mortality.
Methods: From a prospective consecutive cohort (n=150) undergoing major abdominal surgery, whole-blood RNA was collected preoperatively and at 3 time-points postoperatively (2-6, 24, and 48 h).