Publications by authors named "Cuyler Dewar"

Article Synopsis
  • Metatarsal fractures, particularly affecting the fifth metatarsal, are common injuries, making up 5-6% of outpatient fractures, with zone 2 fractures—specifically Jones fractures—being difficult to manage due to poor blood supply and higher nonunion rates.
  • Surgical treatment, particularly open reduction and internal fixation (ORIF), is preferred for Jones fractures, as it leads to better healing rates compared to conservative treatment methods.
  • The surgical technique involves careful anatomical marking and using a guidewire for screw placement to compress the fracture, followed by a recovery period that includes non-weight-bearing and gradual weight-bearing activities.*
View Article and Find Full Text PDF

Background: Foot and ankle injuries frequently require a period of nonweightbearing, resulting in muscle atrophy. Our previous study compared a hands-free single crutch (HFSC) to standard axillary crutches and found increased muscle recruitment and intensity while using the HFSC. Knee scooters are another commonly prescribed nonweightbearing device.

View Article and Find Full Text PDF
Article Synopsis
  • - The study explores the effectiveness of a hands-free single crutch (HFSC) compared to standard axillary crutches (SAC) in reducing muscle atrophy by utilizing both lower limbs for mobility.
  • - Using wireless surface electromyography (EMG), results showed significantly higher muscle activity and voluntary contraction in key muscles (rectus femoris, gluteus maximus, and lateral gastrocnemius) when using the HFSC.
  • - The findings suggest that the HFSC may promote better muscle recruitment during ambulation, potentially accelerating recovery for individuals with lower extremity restrictions compared to traditional crutches.
View Article and Find Full Text PDF

Purpose: Treatment approaches using Hsp90 inhibitors at their maximum tolerated doses (MTDs) have not produced selective tumor toxicity. Inhibition of Hsp90 activity causes degradation of client proteins including those involved in recognizing and repairing DNA lesions. We hypothesized that if DNA repair proteins were degraded by concentrations of an Hsp90 inhibitor below those required to cause nonspecific cytotoxicity, significant tumor-selective radiosensitization might be achieved.

View Article and Find Full Text PDF

Background:: Patient-reported outcome measures (PROMs) are taking a more prominent role in orthopedics as health care seeks to define treatment outcomes. The visual analog scale (VAS) is considered a reliable measure of acute pain. A previous study found that operative candidates' VAS pain score was significantly higher when reported to the surgeon compared to the nurse.

View Article and Find Full Text PDF