Predictors of Repeat Epinephrine Administration for Emergency Department Patients with Anaphylaxis.

Background: Risk factors that predict which patients with anaphylaxis might require repeat doses of epinephrine are poorly understood.

Objective: The objective of this study was to identify risk factors associated with the need for multiple doses of epinephrine during an anaphylactic reaction.

Methods: Patients were included if they met diagnostic criteria for anaphylaxis on presentation to the emergency department (ED) at our academic medical center between April 2008 and February 2014.