Mitochondrial SKN-1/Nrf mediates a conserved starvation response.

SKN-1/Nrf plays multiple essential roles in development and cellular homeostasis. We demonstrate that SKN-1 executes a specific and appropriate transcriptional response to changes in available nutrients, leading to metabolic adaptation. We isolated gain-of-function (gf) alleles of skn-1, affecting a domain of SKN-1 that binds the transcription factor MXL-3 and the mitochondrial outer membrane protein PGAM-5.

CCN2/CTGF increases expression of miR-302 microRNAs, which target the TGFβ type II receptor with implications for nephropathic cell phenotypes.

Signalling interplay between transforming growth factor-β (TGFβ) and CCN2 [also called connective tissue growth factor (CTGF)] plays a crucial role in the progression of diabetic nephropathy and has been implicated in cellular differentiation. To investigate the potential role of microRNAs (miRNAs) in the mediation of this signalling network, we performed miRNA screening in mesangial cells treated with recombinant human CCN2. Analysis revealed a cohort of 22 miRNAs differentially expressed by twofold or more, including members of the miR-302 family.

Pediatric sexual assault nurse examiner care: trace forensic evidence, ano-genital injury, and judicial outcomes.

Introduction: Although pediatric sexual assault nurse examiners (P-SANEs) have been providing care for over two decades there remain major gaps in the literature describing the quality of P-SANE care and legal outcomes associated with their cases. The purpose of this study was to compare quality indicators of care in a pediatric emergency department (PED) before and after the implementation of a P-SANE program described in terms of trace forensic evidence yield, identification of perpetrator DNA, and judicial outcomes in pediatric acute sexual assault.

Method: A retrospective review of medical and legal records of all patients presenting to the PED at Nationwide Children's Hospital with concerns of acute sexual abuse/assault requiring forensic evidence collection from 1/1/04 to 12/31/07 was conducted.

A new species of Homalometron (Digenea: Apocreadiidae) from fishes in the northern Gulf of Mexico.

Homalometron palmeri n. sp. is described and reported from the following fishes in the northern Gulf of Mexico: Micropogonias undulatus, Sciaenops ocellatus, Bairdiella chrysoura, Pogonias cromis, Fundulus grandis, Fundulus similis, and Eucinostomus argenteus.

Heterotopic ossification of the abdominal wall.

Introduction: Heterotopic ossification is a rare, benign condition which occurs when bone develops in tissues that do not normally ossify.

Presentation Of Case: We herein report the case of a 73-year-old gentleman who underwent a laparotomy for a large splenic flexure tumour considered unresectable at initial intervention. Following delivery of chemotherapy, he was referred for a second opinion and the tumour with adjacent structures was removed at a subsequent laparotomy.

Intrarater and interrater reliability of first metatarsophalangeal joint dorsiflexion: goniometry versus visual estimation.

Background: Visual estimation (VE) and goniometric measurement (GM) are commonly used to assess first metatarsophalangeal joint dorsiflexion. The purposes of this study were to determine the intrarater and interrater reliability of VE and GM and to establish whether reliability was influenced by the experience of the examiner.

Methods: Ten experienced and ten inexperienced examiners evaluated three real-size photographs of a first metatarsophalangeal joint positioned in various degrees of dorsiflexion on two separate occasions.

Intensive home haemodialysis: benefits and barriers.

Accumulating evidence of the benefits of intensive home haemodialysis has led to increased international interest in this modality as a viable option for renal replacement therapy. Until the late 1970s, haemodialysis was primarily performed at home; however, the development of in-centre and satellite dialysis units and the advent of peritoneal dialysis led to decreased numbers of patients being managed by home haemodialysis. Over the past decade, a move towards once again providing and supporting haemodialysis at home has emerged, due to a desire to offer a more convenient form of dialysis for the patient in a more cost-effective manner.

Adherence to treatment guidelines in the pharmacological management of chronic heart failure in an Australian population.

Background: To document the pharmacotherapy of chronic heart failure (CHF) and to evaluate the adherence to treatment guidelines in Australian population.

Methods: The pharmacological management of 677 patients (female 46.7%, 75.

Longevity and the long arm of epigenetics: acquired parental marks influence lifespan across several generations.

A recent study reported that longevity in Caenorhabditits elegans can be inherited over several generations. This is probably achieved through the following epigenetic mechanism: inherited demethylated histones at some central loci, such as miRNA, transcription factors or signaling regulators affect the expression of certain genes leading to the longevity phenotype.

Live-cell delamination counterbalances epithelial growth to limit tissue overcrowding.

The development and maintenance of an epithelium requires finely balanced rates of growth and cell death. However, the mechanical and biochemical mechanisms that ensure proper feedback control of tissue growth, which when deregulated contribute to tumorigenesis, are poorly understood. Here we use the fly notum as a model system to identify a novel process of crowding-induced cell delamination that balances growth to ensure the development of well-ordered cell packing.

Registered nurses' and behavior health associates' responses to violent inpatient interactions on behavioral health units.

Background: Violence carried out by patients against nursing staff unsettles and threatens coworkers as they care for individuals admitted to inpatient psychiatric units.

Objective: This study explored nursing staff's individual and group responses to violent incidents performed by patients against caregivers.

Design: This qualitative study used focus groups to collect data from professional nurses and behavioral health associations (N = 19) recruited from urban, inpatient psychiatric unit.

The effects of iron oxide incorporation on the chondrogenic potential of three human cell types.

Non-invasive monitoring of living cells in vivo provides an important tool in the development of cell-based therapies in cartilage tissue engineering. High-resolution magnetic resonance imaging (MRI) has been used to monitor target cell populations in vivo. However, the side-effects on cell function of the labelling reagents, such as superparamagnetic iron oxide (SPIO), are still unclear.

NEW PERSPECTIVES ON IMMIGRANT CONTEXTS OF RECEPTION: The cultural armature of cities.

We argue that important, overlooked differences in what we call the 'cultural armature' of Portland, Maine, and Danbury, Connecticut help explain the variation in how each city received new immigrants in recent years. Portland has a long history of contact with the outside world and used its cosmopolitan character to promote urban redevelopment and welcome immigrants from a range of countries of origin. Danbury's small-town, insular outlook, and the fact that most of its newcomers came from a single country of origin - some without legal documents - made immigrants' welcome more fragmented.

Genetic and functional analyses of SHANK2 mutations suggest a multiple hit model of autism spectrum disorders.

Autism spectrum disorders (ASD) are a heterogeneous group of neurodevelopmental disorders with a complex inheritance pattern. While many rare variants in synaptic proteins have been identified in patients with ASD, little is known about their effects at the synapse and their interactions with other genetic variations. Here, following the discovery of two de novo SHANK2 deletions by the Autism Genome Project, we identified a novel 421 kb de novo SHANK2 deletion in a patient with autism.

Selenide ions as catalysts for homo- and crossed-Tishchenko reactions of expanded scope.

Selenide ions have been shown to catalyze the Tishchenko reaction for the first time. These catalysts are superior to previously reported thiolate analogues and promote the disproportionation of aldehydes with increased reaction rates and broader scope at lower catalyst loadings and temperatures. Significantly improved catalyst performance was also observed in the aryl selenide mediated crossed intermolecular Tishchenko reaction.

Phylogenetic position of Creptotrema funduli in the Allocreadiidae based on partial 28S rDNA sequences.

The infrequently reported allocreadiid digenean Creptotrema funduli Mueller, 1934 is documented from the blackstripe topminnow, Fundulus notatus (Cyprinodontiformes: Fundulidae), in the headwaters of the Biloxi River, Harrison County, Mississippi. Specimens from Mississippi were compared with the type material from Fundulus diaphanus menona from Oneida Lake, New York, and no substantial difference was found. A fragment of ribosomal DNA, comprising a short portion of the 3' end of 18S nuclear rDNA gene, internal transcribed spacer (ITS) genes (including ITS1, 5.

Influence of turnout on foot posture and its relationship to overuse musculoskeletal injury in professional contemporary dancers: a preliminary investigation.

Background: The angle of turnout is thought to predispose professional dancers to overuse musculoskeletal injuries of the lower limb; yet, the influence of angle of turnout on foot posture is currently unknown.

Methods: Twelve professional contemporary dancers (five women and seven men; mean age, 26.8 years) were recruited.

Deletion of Gremlin1 increases cell proliferation and migration responses in mouse embryonic fibroblasts.

Gremlin1 (Grem1) is an antagonist of bone morphogenetic proteins (BMPs) that plays a critical role in embryonic and postnatal development. Grem1 has been implicated as both a promoter and an inhibitor of cell proliferation driven by BMP-4 and other mitogens in a diverse range of cell types. Recent data showed that Grem1 can trigger angiogenesis via vascular endothelial growth factor receptor (VEGFR2) binding, highlighting that the precise modalities of Grem1 signalling require further elucidation.

Intensive hemodialysis: normalizing the "unphysiology" of conventional hemodialysis?

Interest in intensified hemodialysis (HD) regimens is increasing internationally, as there is growing evidence that they are associated with improved outcomes. Appreciation that conventional hemodialysis (CHD), delivered as 4-hour sessions three times a week, is not providing optimal physiological replacement of renal function has led to the development of intensified dialysis therapies. These include long intermittent hemodialysis typically lasting 6-8 hours and delivered three times a week, short daily hemodialysis, providing more frequent sessions 4-7 days a week lasting 2-3.

Changes in the ratio of free NEDD8 to ubiquitin triggers NEDDylation by ubiquitin enzymes.

Ubiquitin and UBL (ubiquitin-like) modifiers are small proteins that covalently modify other proteins to alter their properties or behaviours. Ubiquitin modification (ubiquitylation) targets many substrates, often leading to their proteasomal degradation. NEDD8 (neural-precursor-cell-expressed developmentally down-regulated 8) is the UBL most closely related to ubiquitin, and its best-studied role is the activation of CRLs (cullin-RING ubiquitin ligases) by its conjugation to a conserved C-terminal lysine residue on cullin proteins.