Effect of testosterone on proteoglycans in the submandibular glands of the rat.

The proteoglycans in the submandibular salivary glands of castrated male Wistar rats were studied before and after the daily administration of testosterone propionate (TP) for one month. Castration decreased the weight of the glands and their uronic acid content. The administration of TP reversed these effects.

Effects of castration and androgens upon prostatic proteoglycans in rats.

In studies performed on male Wistar rats, castration induced atrophy of the prostate with a marked increase in the uronic acid content. The administration of testosterone propionate to castrated rats produced opposite effects. Fractionation of the glycosaminoglycans on cellulose microcolumns showed that the changes in uronic acid content in the dorsolateral lobes were due to variations in hyaluronic acid, chondroitin-4-sulfate, and dermatan sulfate, but in the ventral lobes, there were changes in all the chromatographic fractions.

Effects of isoproterenol on I131 uptake by the submaxillary glands in mice.

DL-isoproterenol hydrochloride (1 mg/kg body weight/day) was subcutaneously administered to male A2G mice during 15 or 45 days. The sympathetic superior cervical ganglion of each mouse was resected on the right side, two days before beginning the injections. At the end of the injection period, the I131 submaxillary/plasma ratios and I131 thyroid uptake (%) were measured 3 hours after a tracer dose.

Changes in human parotid salivary protein and sialic acid levels during pregnancy.

Saliva was collected with a Carlson-Crittenden device, under citric acid stimulation, in 107 pregnant women, 9 puerperal and 7 non-pregnant controls. No significant changes were found in salivary flow rate, pH and amylase levels. The total protein levels were decreased during pregnancy and the puerperium.

Effects of anabolic-androgenic steroids on hair waves in castrated mice.

The effects of nandrolone phenylpropionate and decanoate, androstanolone and testosterone propionate, in daily doses from 3 to 100 micrograms during a month, on the diffuse hair wave seen after gonadectomy, were studied in male C 57 mice. The androgenic effects upon anterior prostate weight and the anabolic effects upon levator ani muscle and submaxillary gland weight, were also evaluated. The four steroid compounds used in these experiments had a strong inhibitory effect upon the hair growth waves which was stronger in the anabolic steroids than with testosterone propionate.

Effect of acute hypoxia on blood TSH levels.

The effect of simulated altitude produced by decompression chambers upon the thyroid function was studied in female rats. A significant decrease in blood TSH levels was found when the rats were maintained during 24 hours at a pressure of 0.4 atmosphere, but not at a pressure of 0.

Effects of indomethacin upon 131I uptake by thyroid and submaxillary glands in mice.

The administration of indomethacin to male A2G mice induced a marked decrease in the 131I uptake by the thyroid, but it did not influence the 131I uptake by the submaxillary glands.

Effects of halogenated analogues of cortisol and progesterone upon hair growth in castrated mice.

Several synthetic analogues of cortisol and progesterone were compared to cortisol in their effect of inhibiting the hair growth waves in castrated male C3H/Ep mice. This inhibitory effect was enhanced by fluorination at C-9 alpha and by methylation at C-16 alpha; it decreased by hydroxylation at C-17 alpha and C-21, by removal of hydroxyl group at C-11 and by the addition to bromine to C-12 alpha; it was not modified by oxidation of the hydroxyl group at C-11 or by the delta 1-4 substitution. There was a correlation between the glucocorticoid and hair inhibiting potencies in the cortisol analogues, but some progesterone analogues with very low glucocorticoid activity have marked hair inhibitory effects.

Effects of acetoxyprogesterone upon glycosaminoglycans in the uterus and salivary glands of rats.

The isolation and characterization of glycosaminoglycans was performed in uterus and submaxillary glands of castrated female rats receiving daily doses of 20 or 200 mug of acetoxyprogesterone and 100 or 1000 mug of progesterone. Chromatographic separation of glycosaminoglycans was performed on cellulose microcolumns. The uronic acid concentration in the uterus was decreased by acetoxyprogesterone, in every chromatographic fraction, but not by progesterone.