Developmental toxicity of auranofin in zebrafish embryos.

Auranofin (AF) is used in clinic for the treatment of rheumatoid arthritis, repurposing of AF as an anticancer drug has just finished a phase I/II clinical trial, but the developmental toxicity of AF remains obscure. This study focused on its developmental toxicity by using zebrafish embryos. Zebrafish embryos were exposed to different concentrations (1, 2.

[Optimize the extraction process with supercritical CO2 fluid from lotus leaves by the uniform design and analysis on the chemical constituents by GC-MS].

Objective: To study the optimum parameters of the supercritical CO, fluid extraction of lotus leaves and chemical constituents of extractive matters.

Methods: Supercritical CO2 fluid extraction condition was selected by uniform design. The extraction pressure, extraction temperature, extraction time were three factors in the experiment.

[Study on preparation of beta-cyclodextrin inclusion compound for borneolumsyntheticum from Huoxuezhitong capsules].

Objective: To study the optimum inclusion process of clolloid mill for borneolumsyntheticum from Huoxuezhitong Capsules.

Methods: The study was carried out with orthogonal design. The borneol content in inclusion complex, the utilization ratio of borneol, and synthesis grading were used as evaluating indicator to review the effects of 3 factors, including the proportion of borneolumsyntheticum to beta-cyclodextrin (mol: mol), milling time and water addition.

[Study on the process of inclusion volatile oil of Herba Schizonepetae with beta-cyclodextrin from xiao'er ganmaoshu granule].

Objective: To study optimum inclusion process condition for volatile oil with beta-cyclodextrin (beta-CD).

Methods: The optimum preparation condition were investigated by orthogonal design. The influence of utilization beta-CD and oil, inclusion temperature and time were studied to determin the utilization ratio of volatile oil and oil-bearing rate.

[Determination of triptolide in Tripterygium total terpenoids tablets by HPLC].

Objective: To develop a HPLC method for determination of triptolide in tripterygium total terpenoids tablets.

Method: A Lichrospher CN column was used with ethanol and water for gradient elution. The detection wavelength was set at 255 nm.