A Retrospective Cross-Sectional Analysis of the Humanistic and Economic Burden of Bipolar I Disorder.

Purpose: This study quantified the burdens of bipolar I disorder (BP-I) by examining patient characteristics, health-related quality of life (HRQoL), health care resource utilization (HCRU), and costs of patients with versus without BP-I. Additionally, these outcomes were assessed across BP-I severity levels.

Methods: A retrospective, cross-sectional analysis of the 2020 National Health and Wellness Survey was conducted.

The Humanistic and Economic Burden Associated with Major Depressive Disorder: A Retrospective Cross-Sectional Analysis.

Introduction: Major depressive disorder (MDD) is a debilitating and costly condition. This analysis characterized the health-related quality of life (HRQoL), health care resource utilization (HCRU), and costs between patients with versus without MDD, and across MDD severity levels.

Methods: The 2019 National Health and Wellness Survey was used to identify adults with MDD, who were stratified by disease severity (minimal/mild, moderate, moderately severe, severe), and those without MDD.

Reducing Readmission of Hospitalized Patients With Depressive Symptoms: A Randomized Trial.

Purpose: To determine if hospitalized patients with depressive symptoms will benefit from post-discharge depression treatment with care transition support.

Methods: This is a randomized controlled trial of hospitalized patients with patient health questionnaire-9 score of 10 or more. We delivered the Re-Engineered Discharge (RED) and randomized participants to groups receiving RED-only or RED for Depression (RED-D), a 12-week post-discharge telehealth intervention including cognitive behavioral therapy, self-management support, and patient navigation.

Minimal Effects of Cariprazine on Prolactin Levels in Bipolar Disorder and Schizophrenia.

Background: Many medications used to treat schizophrenia and bipolar I disorder are linked to hyperprolactinemia. The effects of cariprazine, a dopamine D/D receptor partial agonist, on prolactin levels in patients with schizophrenia or bipolar I disorder were evaluated.

Methods: Effects on prolactin were evaluated using pooled data from randomized, double-blind, placebo-controlled studies in patients with schizophrenia (4 studies; 6-week duration; cariprazine 1.

Can Yoga or Physical Therapy for Chronic Low Back Pain Improve Depression and Anxiety Among Adults From a Racially Diverse, Low-Income Community? A Secondary Analysis of a Randomized Controlled Trial.

Objective: To determine and compare the effect of yoga, physical therapy (PT), and education on depressive and anxious symptoms in patients with chronic low back pain (CLBP).

Design: Secondary analysis of a randomized controlled trial.

Setting: Academic safety net hospital and 7 community health centers.

Implementing Measurement-Based Care for Depression: Practical Solutions for Psychiatrists and Primary Care Physicians.

Measurement-based care (MBC) can be defined as the clinical practice in which care providers collect patient data through validated outcome scales and use the results to guide their decision-making processes. Despite growing evidence supporting the effectiveness of MBC for depression and other mental health conditions, many physicians and mental health clinicians have yet to adopt MBC practice. In part, this is due to individual and organizational barriers to implementing MBC in busy clinical settings.

Methodological approaches to situational analysis in global mental health: a scoping review.

Global inequity in access to and availability of essential mental health services is well recognized. The mental health treatment gap is approximately 50% in all countries, with up to 90% of people in the lowest-income countries lacking access to required mental health services. Increased investment in global mental health (GMH) has increased innovation in mental health service delivery in LMICs.

Stability, reliability, and validity of the THINC-it screening tool for cognitive impairment in depression: A psychometric exploration in healthy volunteers.

Objectives: There is a need for a brief, reliable, valid, and sensitive assessment tool for screening cognitive deficits in patients with Major Depressive Disorders. This paper examines the psychometric characteristics of THINC-it, a cognitive assessment tool composed of four objective measures of cognition and a self-rated assessment, in subjects without mental disorders.

Methods: N = 100 healthy controls with no current or past history of depression were tested on four sequential assessments to examine temporal stability, reliability, and convergent validity of the THINC-it tests.

Understory upheaval: factors influencing Japanese stiltgrass invasion in forestlands of Tennessee, United States.

Background: Invasions by non-native plants contribute to loss of ecosystem biodiversity and productivity, modification of biogeochemical cycles, and inhibition of natural regeneration of native species. Japanese stiltgrass (Microstegium vimineum (Trin.) A.

Cognitive Impairment in Major Depressive Disorder: A Case Discussion Illustrating Impact, Assessment, and Management.

How can you help your patients who are experiencing both depression and cognitive dysfunction? Tune in to this CME podcast to hear experts in psychiatry discuss 2 patient cases that illustrate the burden of cognitive impairment in major depressive disorder as well as effective assessment tools and management strategies.

Strategies for Managing Patients With Depression Who Are Experiencing Cognitive Impairment.

Pronounced deficits in executive function are found in up to one-third of patients with MDD, and this impairment can keep patients from achieving full functional recovery. In this CME activity, review the evidence regarding the effectiveness of available interventions to improve cognitive dysfunction in patients with MDD.

Cognitive Impairment in Patients With Depression: Awareness, Assessment, and Management.

​​ Cognitive impairment is a common, often persistent, symptom of major depressive disorder (MDD) that is disproportionately represented in patients who have not returned to full psychosocial functioning. The ultimate goal of treatment in depression is full functional recovery, and assessing patients for cognitive impairment and selecting treatments that address cognitive dysfunction should lead to improved functional outcomes. Unfortunately, many clinicians use screening and assessment tools that are not suited for measuring cognitive impairment in patients with depression.

The THINC-Integrated Tool (THINC-it) Screening Assessment for Cognitive Dysfunction: Validation in Patients With Major Depressive Disorder.

Objective: To validate the THINC-integrated tool (THINC-it)-a freely available, patient-administered, computerized screening tool integrating subjective and objective measures of cognitive function in adults with major depressive disorder (MDD).

Methods: Subjects aged 18 to 65 years (n = 100) with recurrent MDD experiencing a major depressive episode of at least moderate severity were evaluated and compared to age-, sex-, and education-matched healthy controls (n = 100). Between January and June 2016, subjects completed the THINC-it, which includes variants of the Choice Reaction Time Identification Task (IDN), One-Back Test, Digit Symbol Substitution Test, Trail Making Test-Part B, and the Perceived Deficits Questionnaire for Depression-5-item (PDQ-5-D).

Recognizing Binge-Eating Disorder in the Clinical Setting: A Review of the Literature.

Objective: Review the clinical skills needed to recognize, diagnose, and manage binge-eating disorder (BED) in a primary care setting.

Data Sources: A PubMed search of English-language publications (January 1, 2008-December 11, 2014) was conducted using the term . Relevant articles known to the authors were also included.

Impact of anxious symptoms and comorbid anxiety disorders on functional impairment in depressed patients.

Patients with depression may have unrecognized anxiety symptoms or comorbid anxiety disorders that hinder their ability to function and their response to treatment. Patients with both depressive and anxious symptoms may be more sensitive to medication adverse effects and require lower starting doses of antidepressants than those with only depression. Regular monitoring of symptoms and functioning should include the use of rating scales to help identify areas of need.

Functional impairment and improvement in depression.

Functional impairment is inherent to depression, but frequently these impairments are more resistant to treatment than the actual symptoms of depression. Unfortunately, a patient cannot truly overcome depression until these impairments are addressed. A number of validated instruments are available to help clinicians assess functional impairment and monitor it throughout treatment.