Publications by authors named "Cuiyin Zhao"
Article Synopsis
- FPR3 regulates gastric cancer (GC) progression by inhibiting aerobic glycolysis and the stemness of tumor cells, which are key factors in cancer growth and resistance to therapy.
- The mechanism involves FPR3's effect on calcium ion flux and the inhibition of NFATc1, which disrupts the expression of NOTCH3 and influences the AKT/mTORC1 signaling pathway.
- This study suggests that targeting FPR3 could offer new strategies for cancer treatment by modifying the metabolic and stem cell properties of GC cells.
Lactate plays an important role in shaping immune tolerance in tumor microenvironment (TME) and correlates with poor prognosis in various solid tumors. Overcoming the immune resistance in an acidic TME may improve the anti-tumor immunity. Here, this study elucidated that via G-protein-coupled receptor 81 (GPR81), lactate could modulate immune tolerance in TME by recruiting regulatory T cells (Tregs) in vitro and in vivo.
View Article and Find Full Text PDFThe gut microbiota and Short-chain fatty acids (SCFAs) can influence the progression of diseases, yet the role of these factors on gastric cancer (GC) remains uncertain. In this work, the analysis of the gut microbiota composition and SCFA content in the blood and feces of both healthy individuals and GC patients indicated that significant reductions in the abundance of intestinal bacteria involved in SCFA production were observed in GC patients compared with the controls. ABX mice transplanted with fecal microbiota from GC patients developed more tumors during the induction of GC and had lower levels of butyric acid.
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