Distinguishing benign and malignant thyroid nodules using plasma trimethylamine N-oxide, carnitine, choline and betaine.

Purpose: Trimethylamine N-oxide (TMAO), a gut microbiome-derived metabolite, and its precursors (carnitine, choline, betaine) have not been fully examined in relation to thyroid cancer (TC) risk. The aim of this study was to assess the value of TMAO and its precursors in diagnosis of benign and malignant thyroid nodules.

Methods: In this study, high-performance liquid chromatography-tandem mass spectrometry was utilized to measure the levels of plasma TMAO and its precursors (choline, carnitine, and betaine) in 215 TC patients, 63 benign thyroid nodules (BTN) patients and 148 healthy controls (HC).

Corrigendum: Epidemiological, clinical, and laboratory features of patients infected with at a tertiary hospital in Hefei City, China.

[This corrects the article DOI: 10.3389/fpubh.2022.

Epidemiological, clinical, and laboratory features of patients infected with at a tertiary hospital in Hefei City, China.

Background: is a bacterium causing potential nosocomial infections and is associated with a high mortality rate; however, the date of patients in the Hefei population who have been diagnosed with this infection is generally limited.

Purpose: The clinical and laboratory data of patients from a tertiary hospital in Hefei City who had infection were evaluated in this retrospective analysis.

Patients And Methods: From May 2017 to November 2021, there were 24 patients infected with in the First Affiliated Hospital of Anhui Medical University.

Structural Requirements and Plasticity of Receptor-Binding Domain in Human Coronavirus Spike.

The most recent human coronaviruses including severe acute respiratory syndrome coronavirus-2 causing severe respiratory tract infection and high pathogenicity bring significant global public health concerns. Infections are initiated by recognizing host cell receptors by coronavirus spike protein S1 subunit, and then S2 mediates membrane fusion. However, human coronavirus spikes undergo frequent mutation, which may result in diverse pathogenesis and infectivity.

Clinical and Laboratory Characteristics of Patients infected by at a Tertiary Hospital in Hefei City, China.

Background: Human listeriosis is a severe foodborne infection caused by and the data of patients with this infection are largely limited for the Hefei population.

Purpose: This is a retrospective study that evaluated the clinical and laboratory data of patients with listeriosis at a tertiary hospital in Hefei City.

Patients And Methods: A total of 24 listeriosis patients were admitted to the First Affiliated Hospital of Anhui Medical University from January 2003 to July 2021.

Epidemiological, Clinical and Laboratory Characteristics of Patients with Infection in Anhui Province, China.

Background: Brucellosis is currently one of the most widespread zoonotic diseases caused by genus, and the is the major pathogen. The number of people infected with has gradually increased in Anhui Province.

Purpose: To retrospectively evaluate the epidemiological, clinical, and laboratory data of brucellosis patients in Anhui Province.

Structural Basis of the Pore-Forming Toxin/Membrane Interaction.

With the rapid growth of antibiotic-resistant bacteria, it is urgent to develop alternative therapeutic strategies. Pore-forming toxins (PFTs) belong to the largest family of virulence factors of many pathogenic bacteria and constitute the most characterized classes of pore-forming proteins (PFPs). Recent studies revealed the structural basis of several PFTs, both as soluble monomers, and transmembrane oligomers.