Nicotinamide mononucleotide attenuates airway epithelial barrier dysfunction via inhibiting SIRT3 SUMOylation in asthma.

Nicotinamide adenine dinucleotide (NAD) is an essential element in cellular metabolism that regulates fundamental biological processes. Growing evidence suggests that a decline in NAD is a common pathological factor in various diseases and aging. However, its role in airway epithelial barrier function in response to asthma remains underexplored.

A Rule of Thumb for Evaluating Surface Areas of Chronic Wounds.

Background: Rapid estimation of the area of chronic wounds is clinically important. A simple method using the thumb was investigated for universal physical measurement, particularly of small and multiple wounds; the thumb surface area (TSA) was then compared with the total body surface area (TBSA).

Methods: A cross-sectional observational study and random sampling were used to obtain the characteristics of 343 participants.