Tumor-derived extracellular vesicles inhibit osteogenesis and exacerbate myeloma bone disease.

: As a hallmark driver of multiple myeloma (MM), MM bone disease (MBD) is unique in that it is characterized by severely impaired osteoblast activity resulting from blocked osteogenesis in bone marrow-derived mesenchymal stem cells (BM-MSCs). The mechanisms underlying this preferential blockade are incompletely understood. : miRNA expression of MM cell-derived extracellular vesicles (MM-EVs) was detected by RNA sequencing.