Publications by authors named "Cuishan Chen"
Objective: Open-heart surgery (OHS) is a stressful event for patients, all of whom experience varying levels of worry and fear, leading to fear of disease progression (FoP). An in-depth understanding of the experiences and needs of FoP in patients after OHS is beneficial for healthcare providers to make optimal decisions, but this has not been reported. We aimed to explore the experiences and needs of FoP in patients after OHS by adopting a qualitative interview method.
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- Maternal serum levels of soluble programmed cell death-1 (sPD-1) and its ligand (sPD-L1) were investigated as potential biomarkers for missed miscarriage (MM), with findings suggesting decreased sPD-L1 levels in MM patients.
- The study involved three cohorts, including a discovery cohort of 108 MM patients and healthy pregnant women, a validation cohort of MM patients and women with induced abortions, and a prospective observational study of IVF patients, all assessing serum levels of sPD-1 and sPD-L1.
- Results showed that sPD-L1 levels in MM patients were significantly lower (about 50% reduction) compared to healthy pregnant controls, indicating its potential role as a predictive biomarker for missed
Neutrophil Extracellular Traps Mediate Acute Liver Failure in Regulation of miR-223/Neutrophil Elastase Signaling in Mice.
Cell Mol Gastroenterol Hepatol
August 2022
Background & Aims: Marked enhancement of neutrophil infiltration in the liver is a hallmark of acute liver failure (ALF), a severe life-threatening disease with varying etiologies. However, the mechanisms and pathophysiological role corresponding to hepatic neutrophil infiltration during ALF development remain poorly characterized.
Methods: Experimental ALF was induced in 10-week-old male microRNA-223 (miR-223) knockout (KO) mice, neutrophil elastase (NE) KO mice, and wild-type controls by intraperitoneal injection of galactosamine hydrochloride and lipopolysaccharide.