Emerging translocator protein-positron emission tomographic imaging improves detection of focal cortical dysplasia.

Objective: The identification of epileptic lesions is crucial for improving surgical outcomes. Nevertheless, substantial focal cortical dysplasia (FCD) may be invisible on magnetic resonance imaging (MRI). We aimed to characterize the expression pattern of 18-kDa translocator protein (TSPO) in FCD and to evaluate the effectiveness of this inflammation-reflective molecular imaging technique for detecting FCD.

Association between Life's Essential 8 and Atherogenic Index of Plasma in adults: insights from NHANES 2007-2018.

Introduction: Cardiovascular Disease (CVD) has become a significant global public health challenge, contributing to rising mortality rates. This study aims to investigate the relationship between Life's Essential 8 (LE8) and the Atherogenic Index of Plasma (AIP), providing insights into the assessment and improvement of Cardiovascular Health (CVH).

Methods: We conducted an analysis of data from 8,215 U.

Demystifying death: a qualitative study using the behavior change wheel framework to explore the palliative care education experiences of doctors, nurses, and community residents.

Objective: To explore the palliative care education experiences of doctors, nurses, and community residents.

Methods: A semi-structured interview was conducted with 2 doctors, 8 nurses and 9 community residents in Jinan. Content analysis and behavior change wheel theory were used to analyze the interview content.

Inflammatory markers as predictors of in-hospital mortality in acute exacerbation of chronic obstructive pulmonary disease (AECOPD) patients with acute respiratory failure: insights from the MIMIC-IV database.

Background: Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) particularly when coupled with acute respiratory failure (ARF), markedly elevates mortality rates. This investigation focuses on pivotal inflammatory markers in exacerbations of chronic obstructive pulmonary disease (COPD), including the neutrophil-to-lymphocyte ratio (NLR), lactate-to-albumin ratio (LAR), glucose-to-lymphocyte ratio (GLR), prognostic nutritional index (PNI), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII), which are easily determinable from peripheral blood. We aimed to investigate the prognostic value of NLR, LAR, GLR, SII, PNI, and PLR for in-hospital mortality among AECOPD patients with ARF.

Simultaneous intracranial recordings of interacting brains reveal neurocognitive dynamics of human cooperation.

Cooperative interactions profoundly shape individual and collective behaviors of social animals. Successful cooperation requires coordinated efforts by cooperators toward collective goals. However, the underlying behavioral dynamics and neuronal mechanisms within and between cooperating brains remain largely unknown.

Eat, Sleep, Console model for neonatal opioid withdrawal syndrome: a meta-analysis.

Background: The rising incidence of drug abuse among pregnant women has rendered neonatal opioid withdrawal syndrome a significant global health concern.

Methods: Databases including PubMed, Web of Science, the Cochrane Library, Embase, Elton B. Stephens.

Association between advanced lung cancer inflammation index and in-hospital mortality in ICU patients with community-acquired pneumonia: A retrospective analysis of the MIMIC-IV database.

Objective: The objective of the present study was to explore the correlation between the advanced lung cancer inflammation index (ALI) and in-hospital mortality among patients diagnosed with community-acquired pneumonia (CAP).

Methods: Data from the Medical Information Mart for Intensive Care-IV database were adopted to analyze the in-hospital mortality of ICU patients with CAP. Upon admission to the ICU, fundamental data including vital signs, critical illness scores, comorbidities, and laboratory results, were collected.

Intracranial EEG signals disentangle multi-areal neural dynamics of vicarious pain perception.

Empathy enables understanding and sharing of others' feelings. Human neuroimaging studies have identified critical brain regions supporting empathy for pain, including the anterior insula (AI), anterior cingulate (ACC), amygdala, and inferior frontal gyrus (IFG). However, to date, the precise spatio-temporal profiles of empathic neural responses and inter-regional communications remain elusive.

Temporal-spatial deciphering mental subtraction in the human brain.

Unlabelled: Mental subtraction, involving numerical processing and operation, requires a complex interplay among several brain regions. Diverse studies have utilized scalp electroencephalograph, electrocorticogram, or functional magnetic resonance imaging to resolve the structure pattern and functional activity during subtraction operation. However, a high resolution of the spatial-temporal understanding of the neural mechanisms involved in mental subtraction is unavailable.

The learning experiences and career development expectations of Chinese nursing master's degree students: A qualitative investigation.

Aim: To explore the learning experiences and career development expectations of nursing master's degree students.

Background: With increasing demands for improved quality of life, there is a growing need for nursing graduate programs in clinical care. However, the existing training programs for nursing master's students in China require improvement.

Comparison of the components of fresh Panax notoginseng processed by different methods and their anti-anemia effects on cyclophosphamide-treated mice.

Ethnopharmacological Relevance: The traditional Chinese herb Panax notoginseng (PN) tonifies blood, and its main active ingredient is saponin. PN is processed by different methods, resulting in different compositions and effects.

Aim Of The Study: To investigate changes in the microstructure and composition of fresh PN processed by different techniques and the anti-anemia effects on tumor-bearing BALB/c mice after chemotherapy with cyclophosphamide (CTX).

A review of natural products targeting tumor immune microenvironments for the treatment of lung cancer.

Lung cancer (LC) produces some of the most malignant tumors in the world, with high morbidity and mortality. Tumor immune microenvironment (TIME), a component of the tumor microenvironment (TME), are critical in tumor development, immune escape, and drug resistance. The TIME is composed of various immune cells, immune cytokines, etc, which are important biological characteristics and determinants of tumor progression and outcomes.

Effect of neuromuscular electrical stimulation in critically ill adults with mechanical ventilation: a systematic review and network meta-analysis.

Background: Neuromuscular electrical stimulation (NMES) is widely used as a rehabilitation methods to restore muscle mass and function in prolonged immobilization individuals. However, its effect in mechanically ventilated patients to improve clinical outcomes remains unclear.

Methods: A comprehensive search was conducted using PubMed, Embase, Web of Science, PEDro, and the Cochrane Library from their inception until December 24th, 2023.

Structural Heredity in Catalysis: CO Self-Selective CeO Nanocrystals for Efficient Photothermal CO Hydrogenation to Methane.

The chemical inertness of CO molecules makes their adsorption and activation on a catalyst surface one of the key challenges in recycling CO into chemical fuels. However, the traditional template synthesis and chemical modification strategies used to tackle this problem face severe structural collapse and modifier deactivation issues during the often-needed post-processing procedure. Herein, a CO self-selective hydrothermal growth strategy is proposed for the synthesis of CeO octahedral nanocrystals that participate in strong physicochemical interactions with CO molecules.

Elaborate tree-like Cu-Ag clusters from green electrodeposition for efficiently electrocatalyzing CO conversion into syngas.

The electrocatalytic carbon dioxide reduction (CORR) is one of the emerging technologies that can effectively transform carbon dioxide (CO) into valuable products. Electrocatalysts deriving from green synthesis methods will significantly help to establish a new green carbon cycle. Herein, a green electrodeposition method without additional reducing agents was used to synthesize Cu-Ag bimetallic catalysts, and it is shown that the combination of Cu and Ag obviously affects the morphology of the Cu-Ag catalysts, resulting in the formation of elaborate tree-like Cu-Ag clusters.

Functional connectomic profile correlates with effective anterior thalamic stimulation for refractory epilepsy.

Background: Deep brain stimulation of the anterior nucleus of the thalamus (ANT-DBS) is an effective treatment for refractory epilepsy; however, seizure outcome varies among individuals. Identifying a reliable noninvasive biomarker to predict good responders would be helpful.

Objectives: To test whether the functional connectivity between the ANT-DBS sites and the seizure foci correlates with effective seizure control in refractory epilepsy.

Human anterior thalamic stimulation evoked cortical potentials align with intrinsic functional connectivity.

Characterizing human thalamocortical network is fundamental for understanding a vast array of human behaviors since the thalamus plays a central role in cortico-subcortical communication. Over the past few decades, advances in functional magnetic resonance imaging have allowed for spatial mapping of intrinsic resting-state functional connectivity (RSFC) between both cortical regions and in cortico-subcortical networks. Despite these advances, identifying the electrophysiological basis of human thalamocortical network architecture remains challenging.

Relationship between work engagement and healthy work environment among Chinese ICU nurses: The mediating role of psychological capital.

Aim: To evaluate the relationship between healthy work environment and work engagement considering the effect of psychological capital among ICU nurses.

Design: The study was cross-sectional design.

Methods: The subjects were 671 registered nurses from 20 ICUs in 18 general hospitals in Shandong province between October 2021 and December 2021.

Comparison of High Flow Nasal Therapy with Non-Invasive Ventilation and Conventional Oxygen Therapy for Acute Hypercapnic Respiratory Failure: A Meta-Analysis of Randomized Controlled Trials.

Purpose: We aimed to evaluate whether high flow nasal cannula (HFNC) is an effective and safe method for adult patients with acute hypercapnic respiratory failure (AHRF).

Methods: We searched the Cochrane Library, Embase, and PubMed databases from inception to August 2022 to obtain randomized controlled trials (RCTs) that compared HFNC with conventional oxygen treatment (COT) or non-invasive ventilation (NIV) in patients with AHRF, and then performed a meta-analysis.

Results: A total of ten parallel RCTs with 1265 individuals were identified.

Deep brain stimulation for patients with refractory epilepsy: nuclei selection and surgical outcome.

Objective: By studying the surgical outcome of deep brain stimulation (DBS) of different target nuclei for patients with refractory epilepsy, we aimed to explore a clinically feasible target nucleus selection strategy.

Methods: We selected patients with refractory epilepsy who were not eligible for resective surgery. For each patient, we performed DBS on a thalamic nucleus [anterior nucleus of the thalamus (ANT), subthalamic nucleus (STN), centromedian nucleus (CMN), or pulvinar nucleus (PN)] selected based on the location of the patient's epileptogenic zone (EZ) and the possible epileptic network involved.

Pain as a risk factor of depression and anxiety symptoms with multiple myeloma during maintenance therapy.

Objective: To investigate the prevalence of depression or anxiety in patient with multiple myeloma (MM) in China during maintenance treatment and its associated influencing factors.

Methods: Patients with MM ( = 160) received maintenance therapy, and control subjects (without MM, = 160) matched on age, sex, and BMI were recruited. Patients completed questionnaires, including the Patient Health Questionnaire-9 (PHQ-9), the Generalized Anxiety Disorder 7-item Scale (GAD-7), and the Verbal Pain Rating Scale (VPRS).

The anterior nucleus of the thalamus plays a role in the epileptic network.

Objectives: We investigated both the metabolic differences and interictal/ictal discharges of the anterior nucleus of the thalamus (ANT) in patients with epilepsy to clarify the relationship between the ANT and the epileptic network.

Methods: Nineteen patients with drug-resistant epilepsy who underwent stereoelectroencephalography were studied. Metabolic differences in ANT were analyzed using [18F] fluorodeoxyglucose-positron emission tomography with three-dimensional (3D) visual and quantitative analyses.

Imbalance between the function of Na-K-2Cl and K-Cl impairs Cl homeostasis in human focal cortical dysplasia.

Objective: Altered expression patterns of Na-K-2Cl (NKCC1) and K-Cl (KCC2) co-transporters have been implicated in the pathogenesis of epilepsy. Here, we assessed the effects of imbalanced NKCC1 and KCC2 on γ-aminobutyric acidergic (GABAergic) neurotransmission in certain brain regions involved in human focal cortical dysplasia (FCD).

Materials And Methods: We sought to map a micro-macro neuronal network to better understand the epileptogenesis mechanism.

Intracranial direct electrical mapping reveals the functional architecture of the human basal ganglia.

The basal ganglia play a key role in integrating a variety of human behaviors through the cortico-basal ganglia-thalamo-cortical loops. Accordingly, basal ganglia disturbances are implicated in a broad range of debilitating neuropsychiatric disorders. Despite accumulating knowledge of the basal ganglia functional organization, the neural substrates and circuitry subserving functions have not been directly mapped in humans.