Sex differences in serum pigment epithelium-derived factor in healthy individuals.

To investigate sexual dimorphism of serum pigment epithelium-derived factor (PEDF) and its influencing factors in healthy individuals. A total of 162 healthy people (69 males, 93 females) who underwent health examinations in our department were selected. Serum PEDF, estradiol and other metabolic indices were measured, and homeostasis model assessment of insulin resistance (HOMA-IR) and homeostasis model assessment of β-cell function (HOMA-β) were calculated to evaluate insulin resistance and β-cell function, respectively.

Serum Pigment Epithelium-Derived Factor Levels are Associated with Estradiol and Decrease After Adjusting for Alanine Aminotransferase in Chinese Women Based on Multiple Linear Regression Analysis.

Purpose: To assess changes in pigment epithelium-derived factor (PEDF) levels in patients with metabolic syndrome (MetS) and to investigate sexual dimorphism in serum PEDF levels and their relationships with estradiol.

Methods: A total of 318 individuals (145 men, 173 women) who underwent health examinations in our department were selected. Serum PEDF, estradiol and other metabolic parameters were determined.

A novel ratiometric fluorescence sensor based on lanthanide-functionalized MOF for Hg detection.

Post-synthesis modification is an effective strategy for the preparation of rare earth organic framework materials and the derivation of high-performance functional materials. Here, we report the preparation of a dual emission Ln-MOF material (Eu-Ca-MOF) using Ca-MOF as the parent framework and introducing Eu ions into its channels through post-synthesis modification. Eu-Ca-MOF has good photoluminescence properties and can be used as a ratiometric fluorescence sensor (I/I) to detect Hg ions in water sensitively.

Efficacy and safety of pasireotide for Cushing's disease: A protocol for systematic review and meta-analysis.

Background: Cushing's disease (CD) is associated with increased risk of mortality, myocardial infarction, stroke, peptic ulcers, fractures and infections. The prevalence of CD is nearly 40 per million and higher in women than in men. When surgery has failed, is not feasible, or has been refused, pharmacotherapy can be considered a valuable option.

Eu-Postdoped UIO-66-Type Metal-Organic Framework as a Luminescent Sensor for Hg Detection in Aqueous Media.

Because of its extreme toxicity, the determination of Hg in aqueous solution is an important subject for human health and environmental monitoring. In this study, a novel UIO-66-type metal-organic framework (MOF) doped with Eu (isophthalic acid and 2,6-pyridinedicarboxylic acid and zirconium chloride served as the organic connectors and metal precursor, respectively) was prepared by a hydrothermal method and postsynthetic modification. The obtained lanthanide MOFs exhibited good photothermal and fluorescence stability in aqueous solution.

The Effects of Adiponectin and Adiponectin Receptor 1 Levels on Macrovascular Complications Among Patients with Type 2 Diabetes Mellitus.

Background/aims: The present study aimed to investigate the serum levels of adiponectin (APN) and adiponectin receptor 1 (AdipoR1) in patients with type 2 diabetes mellitus (T2DM) combined with macrovascular complications (MVC), as well as their correlation with clinical parameters.

Methods: A total of 60 T2DM patients were divided into 2 groups according to the presence of MVC: T2DM + MVC group (n=30) and T2DM group (n=30). Additionally, 30 healthy people were selected as control group (NC group).

Association of MCP-1 rs1024611 polymorphism with diabetic foot ulcers.

Monocyte chemotactant protein-1 (MCP-1), a pro-inflammatory cytokine, plays an important role in inflammatory process. In present study, we evaluated the association of MCP-1 gene rs1024611 polymorphism with risk and clinical characteristics of diabetic foot ulcers (DFUs).This study recruited 116 patients with DFUs, 135 patients with diabetes mellitus (DM) without complications (non-DFU), and 149 healthy controls (HCs).

Effects of exenatide, insulin, and pioglitazone on liver fat content and body fat distributions in drug-naive subjects with type 2 diabetes.

Ectopic accumulation of lipids in nonadipose tissues plays a primary role in the pathogenesis of type 2 diabetes mellitus (T2DM). This study was to examine the effects of exenatide, insulin, and pioglitazone on liver fat content and body fat distributions in T2DM. Thirty-three drug-naive T2DM patients (age 52.

Correlations between A1c, fasting glucose, 2h postload glucose, and β-cell function in the Chinese population.

This study was aimed to assess the associations of hemoglobin A1c (HbA1c), fasting plasma glucose (FPG), and 2h postload plasma glucose (2hPG) with β-cell function in the Chinese population. A total of 913 subjects underwent 75-g oral glucose tolerance test (OGTT) and HbA1c testing. According to OGTT, isolated impaired fasting glucose (i-IFG) was defined as 5.