Enhanced Stability of Melt-Processable Organic-Inorganic Hybrid Manganese Halides for X-Ray Imaging.

Mn-based metal halides scintillators with high photoluminescence quantum yield (PLQY) have recently emerged as promising large-size candidates for X-ray imaging but still remains as difficult challenge in stability and high processing temperatures. Here, three manganese halides are designed by introducing branched chains into organic cations and extending the carbon chains, namely (i-PrTPP)MnBr, (i-BuTPP)MnBr and (i-AmTPP)MnBr, successfully lowered the melting point of manganese halides to 120.2 °C.

Ganoderma lucidum polysaccharide inhibits HSC activation and liver fibrosis via targeting inflammation, apoptosis, cell cycle, and ECM-receptor interaction mediated by TGF-β/Smad signaling.

Background: Ganoderma lucidum polysaccharide (GLP) has many biological properties, however, the anti-fibrosis effect of GLP is unknown at present.

Purpose: This study aimed to examine the anti-fibrogenic effect of GLP and its underlying molecular mechanisms in vivo and in vitro.

Study Design: Both CCl-induced mouse and TGF-β1-induced HSC-T6 cellular models of fibrosis were established to examine the anti-fibrogenic effect of a water-soluble GLP (25 kDa) extracted from the sporoderm-removed spores of G.

Removing the sporoderm from the sporoderm-broken spores of improves the anticancer and immune-regulatory activity of water-soluble polysaccharide.

Plant-derived polysaccharides have demonstrated promising anti-cancer effects immune-regulatory activity. The aim of the current study was to compare the chemical property and the anticancer effects of polysaccharides extracted from the sporoderm-removed spores of the medicinal mushroom (RSGLP), which removed the sporoderm completely, with polysaccharides extracted from the sporoderm-broken spores of (BSGLP). We found that RSGLP has a higher extraction yield than BSGLP.

The relationship between reward context and inhibitory control, does it depend on BMI, maladaptive eating, and negative affect?

Background: Recent studies suggest that higher Body Mass Index (BMI) is associated with reduced inhibitory control in contexts of palatable food. However, due to limitations of previous studies, it remained the question whether this reduction is specific to food contexts, and whether it generalizes to other contexts of reward, such as money. This main question was addressed in the current study.

Inhibitory Performance in Smokers Relative to Nonsmokers When Exposed to Neutral, Smoking- and Money-Related Pictures.

Introduction: Smoking is associated with significant negative health consequences. It has been suggested that deficient inhibitory control may be implicated in (nicotine) addiction, but its exact role has not yet been elucidated. In the current study, our aim was to investigate the role of inhibitory control in relation to nicotine addiction in contexts that differ in terms of reward.

Ganoderma lucidum polysaccharide modulates gut microbiota and immune cell function to inhibit inflammation and tumorigenesis in colon.

This study investigated the effects of water-soluble polysaccharide extracted from the sporoderm-removed spores of Ganoderma lucidum (GLP) against AOM/DSS-induced inflammation, tumorigenesis, and gut microbiota modification, which has never been reported before. Our data revealed that GLP (200 and 300 mg/kg) decreased AOM/DSS-induced colitis and tumorigenesis, manifested by significantly reduced disease activity index score, and total number and size of tumors. Furthermore, GLP ameliorated AOM/DSS-induced microbiota dysbiosis, increased short-chain fatty acid production, and alleviated endotoxemia by inhibiting TLR4/MyD88/NF-κB signaling.

The complete chloroplast genome sequence of Lindau.

Lindau is a member of the family Acanthaceae, which was originated from Yunnan province of China and is used as tea and health promotion. Here, we reported the complete chloroplast genome sequence of using Illumina high-throughput sequencing approach. The size of the chloroplast genome is 144,765 bp in length, containing a pair of inverted repeats (IRs, 17,362 bp) that are separated by the large single-copy (LSC, 92,248 bp), and small single-copy (SSC, 17,793 bp) regions.

Polysaccharides from sporoderm-removed spores of induce apoptosis in human gastric cancer cells via disruption of autophagic flux.

The sporoderm-broken spores of () polysaccharide (BSGLP) have been demonstrated to inhibit carcinogenesis in several types of cancer. However, to the best of our knowledge, the anticancer effects of polysaccharides extracted from the newly developed sporoderm-removed spores of (RSGLP) have not been assessed. The present study first compared the anticancer effects of RSGLP and BSGLP in three gastric cancer cell lines and it was found that RSGLP was more potent than BSGLP in decreasing gastric cancer cell viability.

Qizhen capsule inhibits colorectal cancer by inducing NAG-1/GDF15 expression that mediated via MAPK/ERK activation.

Ethnopharmacological Relevance: Qizhen capsule (QZC) is a traditional Chinese medicine (TCM) preparation that has been widely used in clinical practice and exerts promising therapeutic effects against breast, lung, and gastric cancers. However, studies have not reported whether QZC inhibits colorectal cancer (CRC) development and progression. Meanwhile, the underlying molecular mechanisms of its anticancer activity have not been studied.

Suppression of obesity and inflammation by polysaccharide from sporoderm-broken spore of Ganoderma lucidum via gut microbiota regulation.

Ganoderma lucidum has been shown to have anti-obesity effects. However, polysaccharide extracted from the sporoderm-broken spores of Ganoderma lucidum (BSGLP) against obesity and its underlying mechanisms have never been reported. In the current study, we showed that BSGLP inhibited high-fat diet (HFD)-induced obesity, hyperlipidemia, inflammation, and fat accumulation in C57BL/6 J mice.