Phenolic composition and neuroprotective effects of the ethyl-acetate fraction from against HO-induced apoptotic cell death of primary cortical neuronal cells.

Unlabelled: The study aimed to characterize phenolic compounds of the 's ethyl-acetate fraction (EAF) and assess the neuroprotective effect of EAF using the HO-treated primary cortical neuronal cells (PCNC) model. Using HPLC-ECD, 5 phenolics were identified and quantified from EAF. HO-treated PCNC experiments in vitro showed that pretreatment with EAF increased the GSH-PX and SOD activities and reduced the NO, MDA, and Aβ contents.