Publications by authors named "Cuihua Liu"

Background: BAT1806/BIIB800 (Tofidence™/tocilizumab-bavi), a biosimilar of tocilizumab, demonstrated a high degree of analytical and functional similarity to reference tocilizumab (TCZ) in a comprehensive comparative analytical assessment. Minor differences with respect to TCZ were observed for some attributes and this study assessed the potential impact of these differences through structure activity relationship characterization.

Methods: Structure activity relationship studies were conducted to assess glycation, glycosylation, charge variants, hydrophobicity, oxidation, and deamidation differences, using a range of investigative techniques.

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The pivotal role of ethylene (ETH) in fruit ripening has been extensively studied; however, the function of brassinosteroids (BRs) in regulating fruit ripening remains poorly understood. Specifically, the mechanism by which BRs interact with ETH to affect kiwifruit (Actinidia deliciosa) ripening is unclear. Our research showed that 2 genes encoding transcription factors, AdNAC3 and AdMYB19, and the fruit softening gene AdEXP3 (encoding a cell wall expansion protein, expansin 3) were upregulated by ETH and downregulated by BRs.

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Dimethyl phthalate (DMP) has been extensively utilized as a plasticizer on a global scale for many years. Its presence in the environment and its harmful effects on living organisms have raised concerns. This study aimed to examine its potential developmental neurotoxicity by utilizing zebrafish as a model.

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Bisphenol A (BPA) is a widespread environmental endocrine disruptor (EED) that can cause various environmental and health issues by inducing oxidative stress. The c-Jun N-terminal kinase (JNK) signaling pathway plays a crucial role in oxidative stress-mediated cellular damage. Although folic acid (FA) has demonstrated antioxidant properties, its potential protective effects against BPA-induced developmental and neurotoxicity, as well as the mechanisms involved in the JNK signaling pathway, are still not completely understood.

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  • The study reports on a case of steroid-resistant nephrotic syndrome in a 9-month-old infant caused by novel gene mutations, highlighting the clinical and genetic features of Pierson syndrome.
  • Retrospective analysis included clinical presentation, genetic mutation features, and prognosis, supported by literature searches in various medical databases.
  • The findings revealed specific genetic mutations, common histopathological results, and a trend toward severe outcomes in affected patients, with a significant proportion progressing to end-stage kidney disease.
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  • Adequate stabilization of protein-based biopharmaceuticals is crucial for their durability during manufacturing and storage, and the choice of excipients like histidine plays a key role in this process.
  • Histidine, an essential amino acid, is valued for its unique physicochemical properties that allow it to serve multiple functions such as a buffering agent, stabilizer, and antioxidant in formulations.
  • This review provides insight into the use of histidine in the biopharmaceutical industry, detailing its benefits, commercial applications, and interactions with proteins, ultimately highlighting both its potential and challenges in formulation strategies.
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A new dimeric C-glycoside polyketide chrysomycin F (), along with four new monomeric compounds, chrysomycins G (), H (), I (), J (), as well as three known analogues, chrysomycins A (), B (), and C (), were isolated and characterised from a strain of sp. obtained from a sediment sample collected from the South China Sea. Their structures were determined by detailed spectroscopic analysis.

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  • Tuberculosis (TB) is a major health threat, being the second leading cause of death from an infectious agent, and long-term TB treatment can cause liver injury known as antituberculosis drug-induced liver injury (ATB-DILI).
  • Researchers analyzed blood samples from 107 individuals, comparing healthy controls and TB patients, some of whom developed ATB-DILI early in treatment while others did not.
  • The study found significant changes in the levels of 77 metabolites related to fatty acids and bile acids in patients with ATB-DILI, suggesting that these metabolic pathways are crucial for understanding the condition's progression.
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  • Tocilizumab is a monoclonal antibody that targets the IL-6 receptor, and BAT1806/BIIB800 is a biosimilar developed to match its properties. The study aimed to show that BAT1806/BIIB800 is similar to the original tocilizumab drug (TCZ) in terms of quality attributes.
  • Over 20 methods were used to compare samples from both BAT1806/BIIB800 and TCZ, focusing on their structural and functional properties using techniques like chromatography, mass spectrometry, and cell-based assays.
  • The results indicated that BAT1806/BIIB800 and TCZ are highly similar in key quality aspects, with only minor
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  • * Conducted in China with 44 children aged 1 to 18, the study involved administering rituximab after corticosteroid-induced remission and tracking relapse-free survival over 12 months.
  • * Results showed a significant increase in 12-month relapse-free survival (74.4% in the rituximab group vs. 30.3% historical controls), along with favorable outcomes for long-term survival and tolerability of rituximab treatment.
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  • Camellia japonica, a significant ornamental plant, exhibited leaf spot symptoms in a garden at Jiaying University in southern China, with disease incidence surpassing 15%.
  • Upon analysis, fungal colonies resembling Neofusicoccum were cultured from infected leaves, with specific morphology indicating a match to the genus.
  • Molecular identification using DNA sequences showed over 99% homology with N. parvum, confirming the fungus as the pathogen causing the observed leaf disease.
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Objective: To summarize the clinical and genetic characteristics, treatment and prognosis of four children with Steroid-resistant nephrotic syndrome (SRNS) due to variants of TRPC6 gene.

Methods: Clinical data of four children with SRNS admitted to Children's Hospital Affiliated to Zhengzhou University between May 2020 and August 2022 were collected. Peripheral blood samples were collected from the children and their parents, and whole exome sequencing was carried out.

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Tumor hypoxia is the most common feature of radioresistance to the radiotherapy (RT) of lung cancer and results in poor clinical outcomes. High-linear energy transfer (LET) radiation is a novel RT technique to overcome this problem. However, a limited number of studies have been elucidated on the underlying mechanism(s) of RIBE and RISBE in cancer cells exposed to high-LET radiation under hypoxia.

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Objectives: Juvenile dermatomyositis (JDM) is a chronic autoimmune disease. Some patients remain in an active state even though they were administrated with a combination of corticosteroid and methotrexate. Existing research has suggested that interferon and Janus kinase played an important role in pathogenesis.

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Following carbon ion beam irradiation in mammalian cells, such as used in carbon ion radiotherapy (CIRT), it has been suggested that the balance between whether nonhomologous end joining (NHEJ) or homologous recombination (HR) is utilized depends on the DNA double-strand break (DSB) complexity. Here, we quantified DSB distribution and identified the importance of each DSB repair pathway at increasing depths within the carbon ion spread-out Bragg peak (SOBP) beam range. Chinese hamster ovary (CHO) cell lines were irradiated in a single biological system capable of incorporating the full carbon ion SOBP beam range.

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  • WDR35 variants are linked to Cranioectodermal dysplasia (CED), a rare genetic disorder characterized by facial and skeletal abnormalities, growth issues, and other systemic complications.
  • A case report highlights the first Chinese patient with CED caused by WDR35 variants, presenting atypical symptoms such as ectopic testis alongside common CED traits.
  • This case enhances the understanding of the relationship between specific genetic variations (genotype) and observable traits (phenotype) in CED, offering valuable insights for genetic counseling.
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OX40 (CD134), a member of the TNF receptor superfamily, is a widely studied costimulatory immune checkpoint. Several OX40 agonistic antibodies are in the clinical stage for cancer treatment, among which PF-04518600 is the leader and currently in phase II trial. It has been recognized that one potential mode of action for anti-OX40 antibodies is the deletion of intratumoral Tregs.

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Objectives: To investigate the genotypes of the pathogenic gene and the characteristics of clinical phenotypes in children with Alport syndrome (AS).

Methods: A retrospective analysis was performed for the genetic testing results and clinical data of 19 AS children with gene mutations.

Results: Among the 19 children with AS caused by gene mutations, 1 (5%) carried a new mutation of the gene, i.

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  • BAT1706 is a proposed biosimilar to bevacizumab, a drug used in cancer treatment, and its similarity to the original drug was analyzed in detail.
  • Researchers examined numerous attributes, such as structure, stability, and potency, comparing BAT1706 with bevacizumab from both the US and EU using advanced analytical methods.
  • The findings confirmed that BAT1706 has the same amino acid sequence and structural characteristics as the reference drugs, showing that it is functionally similar in terms of potency and other key properties.
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Volatile esters are major aromas contributing to the organoleptic quality of apple fruit. However, the molecular mechanisms underlying the regulation of volatile ester biosynthesis in apple remain elusive. This study investigated the volatile profiles and transcriptomes of 'Qinguan' (QG) apple fruit during development and/or postharvest storage.

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Cardiovascular diseases (CVD), with high morbidity and mortality, seriously affect people's life and social development. Clinically, reperfusion therapy is typically used to treat ischemic cardiomyopathy, such as severe coronary heart disease and acute myocardial infarction. However, reperfusion therapy can lead to myocardial ischemia reperfusion injury (MIRI), which can affect the prognosis of patients.

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  • Scientists wanted to see how a molecule called miR-181c affects lung cancer cells moving and growing new blood vessels.
  • They looked at data from cancer patients and found that miR-181c was higher, while a gene called RECK was lower in lung cancer.
  • By doing experiments with cancer cells, they discovered miR-181c makes cells move more and helps them produce a substance that encourages blood vessel growth.
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  • Congenital anomalies of the kidney and urinary tracts (CAKUT) are a major cause of kidney failure in children, and the study aimed to explore the genetic diversity and identify risk factors for kidney failure among these children.
  • Researchers analyzed clinical and genetic data from 925 children with CAKUT across China, finding that 10.3% had a genetic diagnosis, with certain genetic variants being linked to an increased risk of kidney failure.
  • The study identified specific prognostic factors for kidney failure, such as having a solitary kidney, certain variants, and being born prematurely, highlighting the need for targeted monitoring in at-risk populations.
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  • A 52-week study examined the effects of daily recombinant human growth hormone (rhGH) on growth in prepubertal Chinese children with chronic kidney disease (CKD).
  • Results showed that those treated with rhGH experienced significant increases in height standard deviation scores and other growth metrics compared to a control group, along with minimal adverse effects.
  • The findings suggest that rhGH is effective and safe for promoting growth in children with CKD, providing valuable insights for physicians treating this patient population.
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