Lysine demethylase 1B (Kdm1b) enhances somatic reprogramming through inducing pluripotent gene expression and promoting cell proliferation.

Lysine demethylase 1B (Kdm1b) is known as an epigenetic modifier with demethylase activity against H3K4 and H3K9 histones and plays an important role in tumor progression and tumor stem cell enrichment. In this study, we attempted to elucidate the role of Kdm1b in somatic cell reprogramming. We found that exogenous expression of Kdm1b in human dermal fibroblasts (HDFs) can influence the epigenetic modifications of histones.

LMCD1 facilitates the induction of pluripotency via cell proliferation, metabolism, and epithelial-mesenchymal transition.

Somatic cell reprogramming was achieved by lentivirus mediated overexpression of four transcription factors called OSKM: OCT3/4, SOX2, KLF4, and c-MYC but it was not very efficient. Here, we reported that the transcription factor, LMCD1 (LIM and cysteine rich domains 1) together with OSKM can induce reprogramming of human dermal fibroblasts into induced pluripotent stem cells (iPSCs) more efficiently than OSKM alone. At the same time, the number of iPSCs clones were reduced when we knocked down LMCD1.

The isotopomer ratios of NO in the Shaying River, the upper Huai River network, Eastern China: The significances of mechanisms and productions of NO in the heavy ammonia polluted rivers.

In order to figure out the effects of nitrogen pollution and dams on NO production paths in the river systems, the isotopomer ratios in NO, NH and NO, as well as N concentrations and physico-chemical characteristics of water and sediments from the Shaying River system, which is the biggest tributary and major NH contributor of the Huai River, were analyzed in the years 2015 and 2016. The results showed that the net productions of NO (△NO) in the river were pretty high, ranging from 12.9 to 440 nmol/L.

[Characteristics of Dissolved CH₄ and N₂O Concentrations of Weihe River in Xinxiang Section in Spring].

Distributions of CH₄ and N₂O concentrations in Weihe River in Xinxiang City were monitored in spring of 2015, and their influencing factors were discussed. The result showed that CH₄ and N₂O were super-saturated in surface water of Weihe River. The variation ranges of two gases' saturations in the surface water of Weihe River were 147.

[Seasonal dynamics of soil organic carbon and active organic carbon fractions in Calamagrostis angustifolia wetlands topsoil under different water conditions].

The experiment was carried in Sanjiang Plain in the northeast of China during the growing season in 2009. Soil organic carbon (SOC), as well as the soil active organic carbon fractions in the 0-20 cm soil layer of Calamagrostis angustifolia wetland under different water conditions were on monthly observation. Based on the research and indoor analysis, the seasonal dynamics of light fractions of soil organic carbon (LFOC) and microbial biomass carbon (MBC) were analyzed.