Molybdenum and Sulfur Doping To Create Active Sites and Regulate d-Band Centers of Ni-Mo-S Electrocatalysts for the Hydrogen Evolution Reaction.

Defining the active sites and further optimizing their activity are of great significance for enhancing the hydrogen evolution reaction (HER) performances, especially for inexpensive Ni-based catalysts doped with metals and nonmetal elements. This work reports the role of the incorporated molybdenum and sulfur in enhancing the HER activity of nickel. The prepared molybdenum and sulfur coincorporated Ni (NMS) electrocatalysts exhibit excellent HER performance, with an overpotential and Tafel slope of 77.

Enhancing Flexible Perovskite Photovoltaic Cells and Modules Through Light-Trapping and Light-Shifting Strategies.

Flexible perovskite photovoltaic devices are typically constructed on flexible polyethylene naphthalate (PEN) substrates, which exhibit near-ultraviolet absorption and high visible-light reflection, leading to significant optical losses. To address this issue, a reusable optical-management sticker tailored for flexible substrates has been proposed in this work. The sticker incorporates a light-shifting material that converts near-ultraviolet light into visible light, enabling photoelectric conversion of near-ultraviolet light.

Chemical cross-linking facilitates antigen uptake and presentation and provides improved protection from Mpox with a dual-antigen subunit vaccine.

Antigen uptake, processing, and presentation are crucial for the immune responses of protein-based vaccines. Herein, we introduced a reversible chemical cross-linking strategy to engineer protein antigens, which can be tracelessly removed upon antigen-presenting cell (APC) uptake and cellular reduction. The chemically cross-linked antigen proteins presented significantly enhanced uptake and epitope presentation by APC.

Pathways for Identifying Problems in Nursing Quality on-Site Supervision: A Descriptive Qualitative Study.

Background: When the nursing department of our hospital checked the ward round records of the head nurse, it was found that some problems could not be found during rounds, and most of the problems found were superficial; Some studies have also found that most nursing managers are only going through the motions during rounds or are unable to identify problems due to a mismatch between their professional competence and the supervised department, or fail to identify superficial or deep-seated problems, making the quality of nursing supervision unsatisfactory.

Purpose: To sort out the ideas and ways for nursing managers to identify problems in on-site supervision of nursing quality and to provide ideas and directions for being able to identify problems, identifying problems quickly, and identifying high-quality problems in the supervision.

Methods: A descriptive qualitative study was used to conduct face-to-face semi-structured interviews with 14 nursing managers from Bethune Hospital in Shanxi, China.

Mid-infrared photoacoustic brain imaging enabled by cascaded gas-filled hollow-core fiber lasers.

Significance: Extending the photoacoustic microscopy (PAM) into the mid-infrared (MIR) molecular fingerprint region constitutes a promising route toward label-free imaging of biological molecular structures. Realizing this objective requires a high-energy nanosecond MIR laser source. However, existing MIR laser technologies are limited to either low pulse energy or free-space structure that is sensitive to environmental conditions.

Synthesizing gas-filled anti-resonant hollow-core fiber Raman lines enables access to the molecular fingerprint region.

The synthesis of multiple narrow optical spectral lines, precisely and independently tuned across the near- to mid-infrared region, is a pivotal research area that enables selective and real-time detection of trace gas species within complex gas mixtures. However, existing methods for developing such light sources suffer from limited flexibility and very low pulse energy, particularly in the mid-infrared domain. Here, we introduce a concept that is based on the combination of an appropriate design of near-infrared fiber laser pump and cascaded configuration of gas-filled anti-resonant hollow-core fiber technology.

SARS-CoV-2 NSP6 reduces autophagosome size and affects viral replication via sigma-1 receptor.

Unlabelled: Autophagy is a cellular self-defense mechanism by which cells can kill invading pathogenic microorganisms and increase the presentation of components of pathogens as antigens. Contrarily, pathogens can utilize autophagy to enhance their own replication. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) NSP6 can interact with ATPase proton pump component to inhibit lysosomal acidification, which was implicated in the autophagy process.

The Impact of Abusive Supervision on Nurses' Organizational Silence: The Multiple Linear Mediation of Psychological Capital and Fear.

Purpose: To assess abusive supervision and organizational silence among nurses and investigate the mediating influence of psychological capital and fear.

Background: Since the end of 2019, China's National Development and Reform Commission (NDRC) department has decided to start the construction of regional medical centers in Shanxi, reducing cross-provincial and cross-regional medical care. In order to improve the overall standard of care in a hospital in a short period of time, health care leadership decision makers may adopt various effective leadership management practices to achieve the set goals and have high work pressure at the same time.

Efficient and Stable Perovskite Solar Cells and Modules Enabled by Tailoring Additive Distribution According to the Film Growth Dynamics.

Gas quenching and vacuum quenching process are widely applied to accelerate solvent volatilization to induce nucleation of perovskites in blade-coating method. In this work, we found these two pre-crystallization processes lead to different order of crystallization dynamics within the perovskite thin film, resulting in the differences of additive distribution. We then tailor-designed an additive molecule named 1,3-bis(4-methoxyphenyl)thiourea to obtain films with fewer defects and holes at the buried interface, and prepared perovskite solar cells with a certified efficiency of 23.

Patterns and characteristics of visits to psychiatric emergency departments: a three-year data study in China.

The composition and characteristics of emergency patients in the Affiliated Brain Hospital, Guangzhou Medical University during 2020-2022 were retrospectively analyzed to provide data support for the optimization of the process of psychiatric emergency and the elastic allocation of emergency medical staff. This study collected data from patients who sought medical attention at the emergency department of the Affiliated Brain Hospital, Guangzhou Medical University between January 1, 2020, and December 31, 2022. The fundamental information of these patients was statistically analyzed using descriptive analytic methods.

A qualitative study of head nurses' experience in China: forced growth during patient safety incidents.

Background: In patient safety accidents, nurse managers are indirectly victimized by the pressures from many aspects and become the second victim. This study delves into the experiences of nurse managers in China, aiming to uncover their cognition and provide reference for relevant managers.

Methods: A descriptive phenomenological approach was used to gain insight into the inner reality of nurse leaders' experiences and management perceptions of experiencing patient safety incidents.

Humoral and cellular immune responses following Omicron BA.2.2 breakthrough infection and Omicron BA.5 reinfection.

The emergence of novel Omicron subvariants has raised concerns regarding the efficacy of immunity induced by prior Omicron subvariants breakthrough infection (BTI) or reinfection against current circulating Omicron subvariants. Here, we prospectively investigated the durability of antibody and T cell responses in individuals post Omicron BA.2.

Development of novel humanized CD19/BAFFR bicistronic chimeric antigen receptor T cells with potent antitumor activity against B-cell lineage neoplasms.

Chimeric antigen receptor T cell (CAR-T) therapy has shown remarkable efficacy in treating advanced B-cell malignancies by targeting CD19, but antigen-negative relapses and immune responses triggered by murine-derived antibodies remain significant challenges, necessitating the development of novel humanized multitarget CAR-T therapies. Here, we engineered a second-generation 4-1BB-CD3ζ-based CAR construct incorporating humanized CD19 single-chain variable fragments (scFvs) and BAFFR single-variable domains on heavy chains (VHHs), also known as nanobodies. The resultant CAR-T cells, with different constructs, were functionally compared both in vitro and in vivo.

Flexible iontronics with super stretchability, toughness and enhanced conductivity based on collaborative design of high-entropy topology and multivalent ion-dipole interactions.

All-solid-state ionic conductive elastomers (ASSICEs) are emerging as a promising alternative to hydrogels and ionogels in flexible electronics. Nevertheless, the synthesis of ASSICEs with concomitant mechanical robustness, superior ionic conductivity, and cost-effective recyclability poses a formidable challenge, primarily attributed to the inherent contradiction between mechanical strength and ionic conductivity. Herein, we present a collaborative design of high-entropy topological network and multivalent ion-dipole interaction for ASSICEs, and successfully mitigate the contradiction between mechanical robustness and ionic conductivity.

Infectious bronchitis virus (IBV) triggers autophagy to enhance viral replication by activating the VPS34 complex.

Autophagy plays an important role in the lifecycle of viruses. However, there is currently a lack of systematic research on the relationship between Infectious Bronchitis Virus (IBV) and autophagy. This study aims to investigate the impact of IBV on autophagy and the role of autophagy in viral replication.

DNA Gate-Based CRISPR-Cas Exponential Amplification System for Ultrasensitive Small Extracellular Vesicle Detection to Enhance Breast Cancer Diagnosis.

Tumor-derived small extracellular vesicles (tEVs) as potential biomarkers possess abundant surface proteins closely related to parent cells, which are crucial for noninvasive cancer diagnosis. However, tEVs exhibit phenotype heterogeneity and low abundance, posing a significant challenge for multiplex detection with a high sensitivity. Herein, we developed a DNA gate-based exponential amplification CRISPR-Cas (DGEAC) system for accurate and ultrasensitive detection of tEVs, which can greatly improve the accuracy of breast cancer (BC) diagnosis.

Cardio-Oncologic Knowledge of Nurses in the Oncology Service: A Multi-Center Survey in China.

Purpose: Elucidation of the cardio-oncologic knowledge among the oncology nurses of tertiary hospitals in Shanxi Province to provide better insights and directions for management by nursing managers.

Background: China's National Health and Wellness Commission issued the Action Plan for Further Improving Nursing Services in June 2023, which requires nurses to provide patients with physical and mental holistic nursing services, such as medical care, condition observation, assistance with treatment, and health guidance. Most oncology patients are treated with chemotherapy, but the modality can cause greater harm to patients, especially cardiotoxicity.

An erythrocyte membrane-camouflaged fluorescent covalent organic framework for starving/nitric oxide/immunotherapy of triple-negative breast cancer.

It is a great challenge to effectively treat triple-negative breast cancer (TNBC) due to lack of therapeutic targets and drug resistance of systemic chemotherapy. Rational design of nanomedicine with good hemocompatibility is urgently desirable for combination therapy of TNBC. Herein, an erythrocyte membrane-camouflaged fluorescent covalent organic framework (COF) loaded with an NO donor (hydroxyurea, Hu), glucose oxidase (GOx) and cytosine-phosphate-guanine oligonucleotides (CPG) (COF@HGC) was developed for imaging-guided starving/nitric oxide (NO)/immunization synergistic treatment of TNBC.

A near-infrared light-activated nanoprobe for simultaneous detection of hydrogen polysulfide and sulfur dioxide in myocardial ischemia-reperfusion injury.

Ischemia-reperfusion-induced cardiomyocyte mortality constitutes a prominent contributor to global morbidity and mortality. However, early diagnosis and preventive treatment of cardiac I/R injury remains a challenge. Given the close relationship between ferroptosis and I/R injury, monitoring their pathological processes holds promise for advancing early diagnosis and treatment of the disease.

Efficient and Stable Perovskite Solar Modules Enabled by Inhibited Escape of Volatile Species.

The intrinsically weak bonding structure in halide perovskite materials makes components in the thin films volatile, leading to the decomposition of halide perovskite materials. The reactions within the perovskite film are reversible provided that components do not escape the thin films. Here, a holistic approach is reported to improve the efficiency and stability of PSMs by preventing the effusion of volatile components.