Calmodulin Triggers Activity-Dependent rRNA Biogenesis via Interaction with DDX21.

Protein synthesis in response to neuronal activity, known as activity-dependent translation, is critical for synaptic plasticity and memory formation. However, the signaling cascades that couple neuronal activity to the translational events remain elusive. In this study, we identified the role of calmodulin (CaM), a conserved Ca-binding protein, in ribosomal RNA (rRNA) biogenesis in neurons.

[Detection of TERC gene amplification by fluorescence in-situ hybridization in cervical intraepithelial lesions].

Objective: To explore the feasibility and practical value of fluorescence in situ hybridization (FISH) detection of TERC gene amplification in cervical intraepithelial lesions (CIN) and squamous cell carcinoma (SCC).

Methods: Tissue microarray was constructed to cover 150 cases of various cervical conditions, including 24 cases of normal cervical mucosa, 78 cases of CINs (CINI, 25 cases; CINII, 21 cases and CINIII, 32 cases) and 48 cases of SCC. FISH was used to detect TERC gene amplification.

[Using three different screening methods to study overweight and simple obesity among children under age 7 in Ningbo city].

Objective: To investigate the occurrence of simple obesity among children under age 7 in Ningbo and to analyze the data regarding body mass index (BMI) from overweight screening under different standards.

Methods: Randomized cluster sampling was adopted and 64 038 children under 7 years old in Ningbo were chosen and their length/height and weight were measured but pathological and secondary obesity cases were excluded. According to the Standardized Height and Weight set by WHO, more than 10% referring to overweight and more than 20% referring to obesity.

[Research on the growth references of height, weight and body mass index for children under 7 years old].

Objective: To understand the varying features and the trend of length/height-for-age, weight-for-age and body mass index(BMI)-for-age of children under six years old in Ningbo city, Zhejiang province.

Methods: By random clustered sampling, 64 038 healthy children under six years old in Ningbo were chosen and their length/height and weight measured. Means, standard deviation and percentiles of length/height-for-age, weight-for-age and BMI were calculated by SAS systems.