Publications by authors named "Cui-qing Liu"
Acetylhydrazine (AcHZ), a major human metabolite of the widely-used anti-tuberculosis drug isoniazid (INH), was considered to be responsible for its serious hepatotoxicity and potentially fatal liver injury. It has been proposed that reactive radical species produced from further metabolic activation of AcHZ might be responsible for its hepatotoxicity. However, the exact nature of such radical species remains not clear.
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- The study investigates the need for more accurate thrombus biomarkers to diagnose venous thromboembolism (VTE) due to the limitations of D-dimer specificity.
- Plasma samples from low-risk and high-risk groups were analyzed using mass spectrometry, identifying 371 proteins, with 30 showing significant differences in expression.
- Among these, von Willebrand factor (VWF) levels were notably higher in the high-risk group, indicating its potential as a biomarker for thrombus in orthopedic surgery patients.
Article Synopsis
- This study aimed to explore the rates and risk factors of metabolic bone disease of prematurity (MBDP) in very low birth weight (VLBW) and extremely low birth weight (ELBW) infants, analyzing data from over 61,000 neonates in China.
- The incidence of MBDP was found to be 19.4% in VLBW and 38.5% in ELBW infants, with higher rates observed in those with lower gestational ages. The MBDP group exhibited lower birth weights, longer hospital stays, and higher rates of related health issues compared to the non-MBDP group.
- Key differences included the MBDP group having a slower feeding
Article Synopsis
- PM exposure increases the risk of vascular dysfunction, but the exact biological response of endothelial cells to PM is still not fully understood.
- In a study using 4-week-old mice exposed to real airborne PM, bronchial and alveolar damage was observed, and a deficit of Cdk5 led to changes in vasoconstriction and myogenic activity in blood vessels.
- The findings suggest that CDK5 is crucial for endothelial cell growth, migration, and response to PM, indicating its role as a sensor for vascular endothelial responses.
Article Synopsis
- * 744 neonates died in 26 NICUs, representing 1.2% of admissions, with preterm deaths being predominant (59.3%), largely due to pulmonary diseases and infections.
- * A significant number of deaths occurred after medical care was withdrawn, often due to parents' concerns about long-term outcomes, highlighting the need for better evaluation and communication regarding treatment options.
Article Synopsis
- The study investigated the short-term outcomes of extremely low birth weight (ELBW) infants in neonatal intensive care units (NICUs) across mainland China, finding that out of 258 infants admitted, the overall survival rate at discharge was 50%.
- Key risk factors for mortality included a birth weight under 750 g and a gestational age less than 28 weeks, while being small for gestational age provided some protection; common complications included respiratory distress syndrome and patent ductus arteriosus.
- This research marks the first comprehensive survey of ELBW infant outcomes in China, highlighting significant regional differences in survival rates and various health challenges faced during NICU stays.
Article Synopsis
- The study examined 301 neonates with purulent meningitis across 23 hospitals, revealing neonatal pneumonia as the most frequent primary illness and fever as the most common symptom.
- Blood cultures showed a positive rate of 23.9%, with Escherichia coli, Klebsiella pneumoniae, and Staphylococcus epidermidis identified as the main pathogenic bacteria.
- The outcome was generally positive, with 85.7% of patients either cured or improved at discharge, although there were 15 reported deaths (5%).
[Investigation of risk factors for hearing impairment in premature infants].
Zhongguo Dang Dai Er Ke Za Zhi
December 2013
Article Synopsis
- The study examined hearing impairment risk factors in 895 premature infants admitted to a neonatal unit over one year, using otoacoustic emissions for detection.
- The initial hearing screening had a failure rate of 38.4%, with notable percentages of failures based on gestational age, birth weight, and conditions like asphyxia and infection.
- Key risk factors identified included gestational age, birth weight, hyperbilirubinemia, and septicemia, highlighting the need for early screening and follow-up for premature infants to facilitate timely intervention.
[Effect of pulmonary surfactant on Th1/Th2 balance in neonates with respiratory distress syndrome].
Zhongguo Dang Dai Er Ke Za Zhi
December 2012
Article Synopsis
- The study aimed to analyze how pulmonary surfactant (PS) affects the immune response in neonates with respiratory distress syndrome (RDS) by measuring specific cytokines and immunoglobulin levels.
- The research involved 58 neonates split into a control group receiving standard care and a PS treatment group receiving surfactant therapy along with mechanical ventilation.
- Results showed that the PS treatment group had improved respiratory function, shorter mechanical ventilation duration, and altered serum levels of immune markers, indicating that PS therapy positively influences the Th1/Th2 balance in these patients.
[Prospective study on in-hospital mortality and its risk factors in very low birth weight infants requring mechanical ventilation].
Zhongguo Dang Dai Er Ke Za Zhi
October 2012
Article Synopsis
- The study aimed to evaluate the characteristics, treatments, and outcomes of very low birth weight infants (VLBWIs) needing mechanical ventilation, while identifying risk factors linked to their mortality in China.
- Data was gathered from 127 VLBWIs admitted to a neonatal care unit, showing a significant in-hospital mortality rate of 41.7% and highlighting key risk factors such as low birth weight and multiple births.
- The SNAPPE-II and CRIB scoring systems proved effective in predicting mortality risk among these infants, indicating a need for improved clinical strategies to manage high-risk cases.
Article Synopsis
- This study investigates the effectiveness of transplanting human neural precursor cells in treating severe brain injuries in newborns.
- Six newborns with various severe conditions, including asphyxia and carbon monoxide poisoning, underwent this procedure with ethical approval and consent.
- Results showed significant improvements in reflexes and muscle tone post-transplant, with most patients achieving normal psychomotor development within a year, while two developed cerebral palsy, suggesting the transplant is a promising treatment but more research is needed.
[Randomized controlled study of targeted tidal volume ventilation for treatment of severe neonatal respiratory distress syndrome].
Zhongguo Dang Dai Er Ke Za Zhi
September 2011
Article Synopsis
- The study aimed to analyze the effectiveness of different ventilation methods for treating severe neonatal respiratory distress syndrome (RDS) in 84 neonates.
- Comparison among three ventilation modes showed that synchronized intermittent positive pressure ventilation with volume guarantee (SIPPV+VG) and high frequency oscillation ventilation (HFOV) significantly improved oxygenation status and reduced ventilation duration compared to intermittent mandatory ventilation (IMV).
- However, the HFOV group had a higher incidence of severe intracranial hemorrhage, indicating a potential risk associated with this method.
Article Synopsis
- The study evaluated the effectiveness of inhaled nitric oxide (iNO) in treating hypoxemic respiratory failure (HRF) in neonates, particularly in settings with limited resources.
- Neonates receiving iNO at an initial dose of 10 parts per million (ppm) showed significant improvements in oxygenation compared to controls, with even better results at a 20 ppm dose.
- The use of iNO resulted in lower mortality rates and less reliance on other treatment methods like surfactant or high-frequency oscillatory ventilation, highlighting its potential benefits in resource-limited environments.
Article Synopsis
- The study focuses on the epidemiology of live births in Julu County, China, revealing a total of 5822 live births over a year, with a higher proportion of males and a small percentage of preterm infants.
- The data indicates that the majority of births had a healthy weight, but neonatal complications such as perinatal asphyxia and prematurity were significant, contributing to 12.8% of infants needing postnatal care.
- The findings highlight a concerning neonatal mortality rate of 7.6‰ and emphasize the need for better education on neonatal resuscitation and improvements in healthcare quality in rural areas.
Article Synopsis
- A prospective study in China examined neonatal acute respiratory disorders (NARD) in NICUs, focusing on their incidence, management, and outcomes from 2004 to 2005.
- A total of 2677 cases of NARD were identified, accounting for 20.5% of NICU admissions, with the highest incidences found in meconium aspiration syndrome and respiratory distress syndrome (RDS).
- The study highlighted the significant impact of advanced respiratory therapies, such as surfactant treatment for RDS, on survival rates and called for improvements in respiratory care standards in emerging regions.
[Effects of selective head cooling with mild hypothermia on serum levels of caspase-3 and IL-18 in neonates with hypoxic-ischemic encephalopathy].
Zhongguo Dang Dai Er Ke Za Zhi
September 2010
Article Synopsis
- The study focused on the effects of selective head cooling (SHC) treatment on serum levels of caspase-3 and IL-18 in neonates with hypoxic-ischemic encephalopathy (HIE).
- THirty-three neonates were split into two groups: one receiving SHC and the other conventional treatment, with serum levels measured at various intervals post-treatment.
- Results showed significant decreases in caspase-3 and IL-18 levels in the SHC group compared to the conventional group, suggesting that SHC may provide neuroprotective effects by reducing these markers.
Article Synopsis
- The study investigates how activation of thromboxane prostanoid (TP) receptors affects blood vessel relaxation, particularly in the presence of cyclic AMP, which usually promotes relaxation.
- It was found that a TP receptor agonist reduced the relaxation effects of agents like isoprenaline and forskolin in rat carotid arteries, indicating that TP receptor activation hinders these processes.
- The inhibition of phosphodiesterases (PDEs) and Rho kinase can restore some of the relaxation effects, suggesting that targeting these pathways could help treat related cardiovascular issues.
Article Synopsis
- The study focuses on measuring IL-4 and IL-13 concentrations in bronchoalveolar lavage fluid (BALF) of neonates with respiratory distress syndrome (RDS) and ventilator-associated pneumonia (VAP).
- Sixty-eight neonates requiring mechanical ventilation were analyzed, with significant differences found in IL-4 and IL-13 levels between those with and without VAP, particularly 96 hours post-ventilation.
- The findings suggest that elevated IL-4 and IL-13 levels in BALF may play a role in regulating the inflammatory immune response in neonates suffering from both RDS and VAP.
Article Synopsis
- Activation of thromboxane prostanoid (TP) receptors leads to strong vasoconstriction, raising vascular tone and blood pressure, which may impair nitric oxide (NO)-mediated vasorelaxation via Rho kinase.
- A study using isolated carotid arteries from rats showed that Rho kinase inhibitors mitigated the inhibitory effects of TP receptor stimulation on relaxation responses, particularly when endothelium was present.
- U46619, a TP receptor agonist, reduced nitric oxide production and phosphorylation of endothelial NO synthase (eNOS), effects that were countered by Rho kinase inhibitors and a specific antagonist for TP receptors.
Article Synopsis
- The study explored the effects of inhaled nitric oxide (iNO) on newborns with meconium aspiration syndrome (MAS), a condition that can cause severe respiratory issues.
- Patients diagnosed with severe MAS were randomly assigned to either receive iNO or standard treatment without it, focusing on their oxygen levels and overall outcomes.
- Results showed no significant differences between the two groups concerning key factors like gestational age or birth weight, indicating similar baseline characteristics for both treatments.
Article Synopsis
- Nitroglycerin's effectiveness as a vasodilator is compromised by tolerance that develops quickly after treatment starts.
- The study investigates T0156, a new PDE5 inhibitor, to see if it can mitigate nitroglycerin tolerance in rat aorts.
- Results show T0156 can maintain relaxation and cyclic GMP levels when nitrates are used, whereas other inhibitors like cilostazol and rolipram do not affect tolerance, indicating the role of PDE5 in nitroglycerin tolerance.
[Prospective clinical survey of respiratory failure in neonates from the Children's Hospital of Hebei Province].
Zhongguo Dang Dai Er Ke Za Zhi
June 2008
Article Synopsis
- The study examined neonatal respiratory failure (RF) in a NICU in Hebei Province, finding an incidence rate of 35.7% among 304 infants over a one-year period.
- Major causes of RF included respiratory distress syndrome, amniotic fluid aspiration syndrome, and pneumonia, with a mortality rate of 5.6% among affected infants.
- Survivors had an average hospital stay of about 15 days and incurred medical costs averaging 7977 CNY, highlighting the need for improved respiratory therapy and perinatal care to reduce adverse outcomes.
Article Synopsis
- The discovery of ACE2 and the Mas receptor has expanded our understanding of the renin-angiotensin system (RAS), which plays a critical role in regulating blood pressure and cardiovascular health.
- ACE2 converts angiotensin II into angiotensin 1-7, which has beneficial effects like relaxing blood vessels and preventing cell growth, mainly through its interaction with the Mas receptor.
- This ACE2-angiotensin 1-7-Mas axis shows promise as a potential therapeutic target for managing hypertension and cardiovascular diseases.
Article Synopsis
- The study examines the role of nuclear factor-kappa B (NF-kappaB) in the inflammatory response and injury in the lungs of neonates with hyaline membrane disease (HMD).
- It involved analyzing bronchoalveolar lavage fluid from 31 preterm infants, comparing survivors and nonsurvivors to understand NF-kappaB expression and its inhibitor.
- Results showed specific NF-kappaB complexes in the samples, suggesting a significant relationship between NF-kappaB activation and the severity of HMD outcomes.
[Significance of soluble intercellular adhesion molecule-1 and procalcitonin in diagnosis of neonatal septicemia].
Zhonghua Er Ke Za Zhi
September 2004
Article Synopsis
- Neonatal septicemia is a serious condition affecting newborns, with an incidence rate of 1 to 8 per thousand live births and a mortality rate of up to 50% when untreated. Early symptoms are often vague, and standard blood tests lack sensitivity.
- The study examined 50 septic newborns and compared them to 35 healthy newborns to evaluate the effectiveness of soluble intercellular adhesion molecule-1 (sICAM-1), procalcitonin (PCT), and C-reactive protein (CRP) as diagnostic tools for septicemia.
- Data analysis included various statistical methods to determine the sensitivity and specificity of the tested biomarkers (sICAM-1, PCT,