Publications by authors named "Cui-li Cao"
The complete chloroplast genome and phylogenetic analysis of subsp (Craib) T. C. Chen 1988.
Mitochondrial DNA B Resour
March 2024
subsp. (Craib) T. C.
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- Tetramethylpyrazine (TMP), derived from the Chuanxiong herb, promotes differentiation of human neuroblastoma SH-SY5Y cells into neurons by targeting the protein topoisomerase IIβ (TopoIIβ).
- The study found that TMP treatment increased neuronal markers and neurite outgrowth without harming cell survival, while also boosting TopoIIβ and Sp1 expression, suggesting a key role of the PI3K/Akt pathway in this process.
- Ultimately, the research highlights a specific signaling pathway (PI3K/Akt/Sp1/TopoIIβ) crucial for TMP-induced neuronal differentiation, with implications for neuroscience and potential therapeutic applications for nervous system diseases.
Acute and chronic lead (Pb) exposure might cause hypertension and cardiovascular diseases. The purpose of this study was to evaluate the effects of early acute exposure to Pb on the cellular morphology, apoptosis, and proliferation in rats and to elucidate the early mechanisms involved in the development of Pb-induced hypertension. Very young Sprague-Dawley rats were allowed to drink 1% Pb acetate for 12 and 40 days.
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- Small cell lung cancer (SCLC) is very aggressive, and this study explored why a specific SCLC cell line (H446/VP) is resistant to the chemotherapy drug etoposide (VP-16).
- Researchers measured cell viability and examined the expressions of various genes related to drug resistance and apoptosis using several laboratory techniques.
- Results showed that H446/VP cells require much higher concentrations of VP-16 to be affected, with changes in gene expressions indicating increased resistance mechanisms, particularly through alterations in the MDR1 gene and apoptotic pathways.
An increasing number of studies support the presence of stem-like cells in human malignancies. These cells are primarily responsible for tumor initiation and thus considered as a potential target to eradicate tumors. CD133 has been identified as an important cell surface marker to enrich the stem-like population in various human tumors.
View Article and Find Full Text PDF[Left lower first premolar with 3 root canals: a case report].
Hua Xi Kou Qiang Yi Xue Za Zhi
August 2007
Article Synopsis
- The treatment of a left lower first premolar revealed three root canals, which were confirmed through both preoperative and postoperative radiographs.
- This finding highlights the complexity of root canal structures in lower premolars.
- Emphasizing the root canal variety in lower premolars is important to prevent complications and treatment failures.
[The dynamic changes of heme oxygenase-1 mRNA and protein express at subfornical organ in rats with experimental allergic encephalomyelitis].
Zhongguo Ying Yong Sheng Li Xue Za Zhi
February 2006
Aim: To observe the dynamic changes of heme oxygenase-1 (HO-1) mRNA and protein express in subfornical organ in rats with experimental allergic encephalomyelitis (EAE) to confirm that SFO is one of the sites for blood-bearing signaling molecules entering into brain.
Methods: EAE was induced by CFA-GPSCH on Wistar rats, we observed the levels of HO-1 mRNA and its protein expression with immunohistochemistry and in situ hybridization technology on 1 d, 7 d, 14 d, and 21 d after EAE induction in SFO of rats. The relationship between HO-1 and symptoms of EAE was also investigated.
To investigate the role of activated nuclear factor-kappaB (NF-kappaB) in experimental allergic encephalomyelitis (EAE), the activity and protein expression of NF-kappaB p65 in rat brain tissues, which were extracted from EAE rats at 1, 7, 14 and 21 d respectively after EAE was induced by CFA-GPSCH, were measured with electrophoretic mobility shift assay and immunohistochemistry. The relationship between activated NF-kappaB and symptoms of EAE was also investigated. The results showed that protein expression level and the activity of NF-kappaB were very low in the brain of the control group.
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