Chemical properties and antioxidant activity of a water-soluble polysaccharide from Dendrobium officinale.

In this report, a water-soluble polysaccharide was obtained from the dried stems of Dendrobium officinale Kimura et Migo by hot-water (70-75°C) extraction and 85% ethanol precipitation, and successively purification by DEAE-cellulose anion-exchange chromatography and gel-permeation chromatography. The D. officinale polysaccharide (DOP) has a molecular weight of 8500Da.

Effect of a novel synthesized sulfonamido-based gallate-SZNTC on chondrocytes metabolism in vitro.

The ideal therapeutic agent for treatment of osteoarthritis (OA) should have not only potent anti-inflammatory effect but also favorable biological properties to restore cartilage function. Gallic acid (GA) and its derivatives are anti-inflammatory agents reported to have an effect on OA (Singh et al., 2003) [1].

Novel function of N,N-bis(2-chloroethyl)docos-13-enamide for reversal of multidrug resistance in tongue cancer.

Multidrug resistance (MDR) is a key element in the failure of chemotherapies, and development of agents to overcome MDR is crucial to improving cancer treatments. The overexpression of glutathione-S-transferases (GSTs) is one of the major mechanisms of MDR. Because some agents used in traditional Chinese medicine have strong antitumor effects coupled with low toxicity; we investigated the ability of N,N-bis(2-chloroethyl)docos-13-enamide (compound J), the synthesized analog of a highly unsaturated fatty acid from Isatis tinctoria L.

Synthesis and interaction of bovine serum albumin with p-hydroxybenzoic acid derivatives.

Three novel p-hydroxybenzoic acid derivatives (HSOP, HSOX, HSCP) were synthesized from p-hydroxybenzoic acid and sulfonamides (sulfamonomethoxine sodium, sulfamethoxazole and sulfachloropyridazine sodium) and characterized by elemental analysis, HNMR and MS. Interactions between derivatives and bovine serum albumin (BSA) were studied by fluorescence quenching spectra, UV-vis absorption spectra and time-resolved fluorescence spectra. Based on fluorescence quenching calculation and Förster's non-radioactive energy transfer theory, the values of the binding constants, basic thermodynamic parameters and binding distances were obtained.

4-Hy-droxy-3,5-dimeth-oxy-N-{4-[(5-methyl-1,2-oxazol-3-yl)sulfamo-yl]phen-yl}benzamide methanol monosolvate.

The title compound, C(19)H(19)N(3)O(7)S·CH(3)OH, was synthesized from syringic acid and sulfamethoxazole. The benzene rings make a dihedral angle of 41.8 (1)° and the isoxazole ring is twisted by 74.

(E)-Methyl 3-(3,4-dihy-droxy-phen-yl)acrylate.

The benzene ring in the title compound, C(10)H(10)O(4), makes an angle of 4.4 (1)° with the C-C-C-O linker. The hy-droxy groups are involved in both intra- and inter-molecular O-H⋯O hydrogen bonds.

catena-Poly[[[diaqua-sodium]-di-μ-aqua] 2-(2-pyrid-yl)quinoline-4-carboxyl-ate].

In the title compound, [Na(H(2)O)(4)](C(15)H(9)N(2)O(2)), the Na(+) ion is coordinated by six water mol-ecules in an octa-hedral geometry. The NaO(6) octa-hedra are connected by sharing edges, forming a cationic chain along the b-axis direction. O-H⋯O and O-H⋯N hydrogen bonds link the chains and the 2-(2-pyrid-yl)quinoline-4-carboxyl-ate anions into a two-dimensional network parallel to (100).

[Orthogonal experiment of the extraction of triterpenoids from stems of Hyptis suaveolens with microwave].

Objective: To study the best technology of the extraction of triterpenoids from the stems of Hyptis suaveolens with microwave.

Methods: Orthogonal experiment was carried out to investigate 4 influential factors as follows: the time (A), the temperature (B), the solid fluid compared to (C), the NaOH density (D).

Results: The optimal conditions for microwave extraction were A1 B2 C3 D2.

(3,6-Dichloro-pyridin-2-yl)(3,5-dimethyl-1H-pyrazol-1-yl)methanone.

In the crystal structure of the title compound, C(11)H(9)Cl(2)N(3)O, mol-ecules are held together by short inter-molecular Cl⋯Cl contacts [3.319 (1) Å] and C-H⋯N hydrogen bonds, forming two-dimensional networks parallel to (01).

Bis[6-(3,5-dimethyl-1H-pyrazol-1-yl-κN)picolinato-κN,O]manganese(II) bis-(3,5-dinitro-benzoic acid) solvate.

In the title complex, [Mn(C(11)H(10)N(3)O(2))(2)]·2C(7)H(4)N(2)O(6), the Mn(II) atom has a disorted octa-hedral coordination formed by four N and two O atoms of two mer-6-(3,5-dimethyl-1H-pyrazol-1-yl)picolinate ligands (DMPP). Each of the two symmetry-independent 3,5-dinitro-benzoic acid mol-ecules is linked to the mol-ecule of the complex via a hydrogen bond involving its carboxylic H atom and one of the DMPP ligands of the complex. However, in one of the DMPP ligands, the non-coordinated carbonyl O atom serves as the hydrogen-bond acceptor, whereas in the second ligand it is the Mn-coordinated O atom which is involved in the hydrogen bonding.

[6-(3,5-Dimethyl-1H-pyrazol-1-yl)picolinato](pyridine-2,6-dicarboxyl-ato)copper(II) dihydrate.

In the title complex, [Cu(C(7)H(4)NO(4))(C(11)H(10)N(3)O(2))]·2H(2)O, the Cu(II) atom is in a distorted octa-hedral geometry. The equatorial plane is formed by two N atoms and one O atom from 6-(3,5-dimethyl-1H-pyrazol-1-yl)picolinate and by one N atom from pyridine-2,6-dicarboxyl-ate (pdc). Two pdc O atoms occupy the axial positions.

3β-Hydroxy-friedelan-17β-carboxylic acid.

The title compound, C(30)H(50)O(3), which was isolated from a marine endophytic fungus, is a new friedelan derivative. The mol-ecule contains five six-membered rings, which exhibit boat (ring A), distorted boat (ring B) and chair (rings C-E) conformations. The crystal structure is stabilized by inter-molecular O-H⋯O hydrogen bonds, which link neighbouring mol-ecules into 12-membered rings.

3,6-Dichloro-N-(4,6-dichloro-pyrimidin-2-yl)picolinamide.

In the title compound, C(10)H(4)Cl(4)N(4)O, the pyridine and pyrimidine rings are nearly perpendicular to each other, the dihedral angle between them being 86.60 (10)°. In the crystal structure, the N and O atoms in the amide group are involved in inter-molecular hydrogen bonds, forming a one-dimensional chain along the c axis.

Bis[6-(3,5-dimethyl-1H-pyrazol-1-yl)picolinato-κN,O]cadmium(II) 1.75-hydrate.

In the title complex, [Cd(C(11)H(10)N(3)O(2))(2)]·1.75H(2)O, the Cd atom is coordinated by four N atoms and two O atoms from two tridentate 6-(3,5-dimethyl-1H-pyrazol-1-yl)picolinate ligands in a distorted cis-N(4)O(2) octa-hedral geometry. Three water mol-ecules, with occupancies of 1.

Diaqua-bis[6-(3,5-dimethyl-1H-pyrazol-1-yl)picolinato-κN,N',O](nitrato-κO,O')lanthanum(III) monohydrate.

In the title complex, [La(C(11)H(10)N(3)O(2))(2)(NO(3))(H(2)O)(2)]·H(2)O, the La atom is coordinated by four N atoms and six O atoms derived from two 6-(3,5-dimethyl-1H-pyrazol-1-yl)picolinate ligands, one nitrate anion and two water mol-ecules. The mol-ecules are linked together via hydrogen bonds involving the water mol-ecules, forming a three-dimensional network.

Aqua-tris[6-(3,5-dimethyl-1H-pyrazol-1-yl)picolinato]-κN,N',O;κO-dysprosium(III) trihydrate.

In the title complex, [Dy(C(11)H(10)N(3)O(2))(3)(H(2)O)]·3H(2)O, the Dy(III) atom is coordinated by four N atoms and four O atoms derived from three tridentate deprotonated 6-(3,5-dimethyl-1H-pyrazol-1-yl)picolinate ligands and one water mol-ecule. The complex and solvent water mol-ecules are linked together via O-H⋯O, O-H⋯N, C-H⋯O and C-H⋯π hydrogen-bonding inter-actions, forming a three-dimensional network structure.

Tris[6-(3,5-dimethyl-1H-pyrazol-1-yl)picolinato]gadolinium(III) methanol hemisolvate 2.5-hydrate.

In the title complex, [Gd(C(11)H(10)N(3)O(2))(3)]·0.5CH(4)O·2.5H(2)O, the Gd atom is coordinated by six N atoms and three O atoms derived from three tridentate monoanionic 6-(3,5-dimethyl-1H-pyrazol-1-yl)picolinate ligands.

Nitrato(1,10-phenanthroline)(1H-1,2,4-triazole-3-carboxyl-ato)copper(II).

In the title complex, [Cu(C(3)H(2)N(3)O(2))(NO(3))(C(12)H(8)N(2))], the Cu(II) ion is coordinated by an N and an O atom from a bidentate 1H-1,2,4-triazole-3-carboxyl-ate (TRIA) ligand, two N atoms from a 1,10-phenanthroline (phen) ligand, and an O atom from a nitrate ligand in a slightly distorted square-pyramidal environment. In the crystal structure, inter-molecular N-H⋯O hydrogen bonds link mol-ecules into one-dimensional chains propagating along the b axis direction.

Bis[3-chloro-6-(3,5-dimethyl-1H-pyrazol-1-yl)picolinato-κO,N,N']copper(II) tetra-hydrate.

In the title complex, [Cu(C(11)H(9)ClN(3)O(2))(2)]·4H(2)O, the Cu(II) atom is in a distorted octa-hedral coordination environment, coordinated by four N atoms and two O atoms from two tridentate 3-chloro-6-(3,5-dimethyl-1H-pyrazol-1-yl)picolinate ligands. The mol-ecules are linked via inter-molecular O-H⋯O hydrogen bonds involving water mol-ecules to form extended chains along [010], and there are short Cl⋯Cl contacts [3.153 (4) Å].

Bis[6-(3,5-dimethyl-1H-pyrazol-1-yl)picolinato]manganese(II) trihydrate.

In the title complex, [Mn(C(11)H(10)N(3)O(2))(2)]·3H(2)O, the Mn(II) atom is coordinated by four N atoms and two O atoms in a distorted octa-hedral geometry. The mol-ecules are linked together via hydrogen bonds involving the water molecules. One of these is disordered equally over two positions.

Bis[6-(3,5-dimethyl-1H-pyrazol-1-yl)picolinato]nickel(II)-aqua-[6-(3,5-dimethyl-1H-pyrazol-1-yl)picolinic acid]dithio-cyanato-nickel(II) (1/1).

In the title cocrystal, [Ni(C(11)H(10)N(3)O(2))(2)]·[Ni(NCS)(2)(C(11)H(11)N(3)O(2))(H(2)O)], both Ni(II) ions are in disorted octa-hedral coordination environments. One Ni(II) ion is coordinated by four N atoms and two O atoms from two tridentate 6-(3,5-dimethyl-1H-pyrazol-1-yl)picolinate (DPP) ligands, while the other Ni(II) ion is coordinated by a tridentate 6-((3,5-dimethyl-1H-pyrazol-1-yl))picolinic acid (DPPH) ligand and by two N atoms and one O atom from two thio-cyanate and one water ligand, respectively. In the crystal structure, mol-ecules are linked by inter-molecular O-H⋯O and O-H⋯S hydrogen bonds, forming extended chains along [010].

Chlorido(1,10-phenanthroline)(1H-1,2,4-triazole-3-carboxyl-ato)copper(II).

The title complex, [Cu(C(3)H(2)N(3)O(2))Cl(C(12)H(8)N(2))], crystallizes with two independent mol-ecules in the asymmetric unit. Each Cu(II) atom is coordinated by an N atom and an O atom from the bidentate 1H-1,2,4-triazole-3-carboxyl-ate ligand, two N atoms from the 1,10-phenanthroline ligand, and the Cl atom. The coordination geometry is based on a ClN(3)O square pyramid.

Bis[3-chloro-6-(3,5-dimethyl-1H-pyrazol-1-yl)picolinato]nickel(II) tetra-hydrate.

In the title complex, [Ni(C(11)H(9)ClN(3)O(2))(2)]·4H(2)O, the Ni atom is coordinated by four N atoms and two O atoms derived from two tridentate 3-chloro-6-(3,5-dimethyl-1H-pyrazol-1-yl)picolinate ligands. The cis-N(4)O(2) donor set defines a distorted octa-hedral geometry. In the crystal structure, the complex and water mol-ecules are linked by O-H⋯O hydrogen bonds.

[3-Chloro-6-(3,5-dimethyl-1H-pyrazol-1-yl)picolinato](pyridine-2,6-dicarboxyl-ato)nickel(II) dihydrate.

In the title compound, [Ni(C(11)H(9)ClN(3)O(2))(C(7)H(3)NO(4))]·2H(2)O, the Ni(II) atom is coordinated by two N atoms and one O atom of 3-chloro-6-(3,5-dimethyl-1H-pyrazol-1-yl)picolinate and by one N atom and two O atoms of pyridine-2,6-dicarboxyl-ate in a distorted octa-hedral coordination. In the crystal structure, mol-ecules are linked together by inter-molecular O-H⋯O hydrogen bonds. One water mol-ecule is disordered over two positions; the site occupancies are ca 0.