Publications by authors named "Cui-Qing Yan"
Article Synopsis
- Bone cement leakage is a significant complication in treating Kümmell's disease via percutaneous vertebroplasty, leading to a study of clinical outcomes with and without leakage.
- The research included 64 patients, dividing them into two groups based on bone cement leakage observed in X-rays, and compared various health metrics and outcomes before and after surgery.
- Results showed that patients with leakage had more severe disease characteristics, but both groups experienced improvements in pain and disability post-surgery without significant differences between them.
Article Synopsis
- DNA hydroxylation by Tet dioxygenases is common in embryonic stem cells and neurons, but its specific functions in living organisms are still unclear.
- Research shows that Tet1 is crucial for the proliferation of neural progenitor cells in the adult mouse brain, and mice without Tet1 have issues with learning and memory due to impaired neurogenesis in the hippocampus.
- In neural progenitor cells lacking Tet1, certain genes that promote cell proliferation are hypermethylated and downregulated, suggesting Tet1's role in epigenetically regulating these cells in the adult brain.
Cytosine methylation of genomic DNA controls gene expression and maintains genome stability. How a specific DNA sequence is targeted for methylation by a methyltransferase is largely unknown. Here, we show that histone H3 tails lacking lysine 4 (K4) methylation function as an allosteric activator for methyltransferase Dnmt3a by binding to its plant homeodomain (PHD).
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