Highly Efficient Analysis on Biomass Carbohydrate Mixtures by DREAMTIME NMR Spectroscopy.

Proton (H) NMR spectroscopy presents a powerful tool for biomass mixture studies by revealing the involved chemical compounds with identified ingredients and molecular structures. However, conventional H NMR generally suffers from spectral congestion when measuring biomass mixtures, particularly biomass carbohydrate samples, that contain various physically and chemically similar compounds. In this study, a targeted detection NMR approach, DREAMTIME, is exploited for studying biomass carbohydrate mixtures by spectroscopically targeting the desired compounds in separate 1D NMR spectra.

Impact of health information seeking behavior and digital health literacy on self-perceived health and depression symptoms among older adults in the United States.

Background: Understanding the impact of digital health literacy and health information-seeking behavior on the self-perceived health and depression symptoms of older adults is crucial, particularly as the number of older internet users is increasing.

Methods: This study utilized data from the Health Information National Trends Survey to examine the relationship between these factors and the health outcomes of adults aged 50 and above.

Results: The study found that digital health literacy has a positive but non-significant relationship with self-perceived health when other factors are considered.

Study on numerical simulation of groundwater flow field and slope stability in multi-aquifer open pit mine.

Water is one of the most important influences on slope stability in open pit mines. In order to solve the problem of slope stability analysis in multi-aquifer open pit mines, the open pit mine in Block I of Thar Coalfield in Pakistan with multiple aquifers was taken as the research background. The groundwater flow field at different excavation phases was analyzed by numerical simulation method.

A dual dimensional optimization strategy for automatic osteotomy preoperative planning in congenital radioulnar synostosis.

Congenital radioulnar synostosis (CRUS) presents a complex forearm deformity, requiring precise osteotomy planning for anatomical restoration. This study proposes an automatic osteotomy preoperative planning method for forearms with CRUS. Proximal forearm bones are first aligned with the template forearm and then a dual dimensional optimization (DDO) strategy is used to optimize the spatial transformation parameters of the distal fragment.

Itaconate facilitates viral infection via alkylating GDI2 and retaining Rab GTPase on the membrane.

Metabolic reprogramming of host cells plays critical roles during viral infection. Itaconate, a metabolite produced from cis-aconitate in the tricarboxylic acid cycle (TCA) by immune responsive gene 1 (IRG1), is involved in regulating innate immune response and pathogen infection. However, its involvement in viral infection and underlying mechanisms remain incompletely understood.

Automatic calculation method for stenosis ratio based on dialysis access ultrasound image segmentation.

Background: Dialysis Access (DA) stenosis impacts hemodialysis efficiency and patient health, necessitating exams for early lesion detection. Ultrasound is widely used due to its non-invasive, cost-effective nature. Assessing all patients in large hemodialysis facilities strains resources and relies on operator expertise.

Evaluating the safety and effectiveness of α-blockers versus mirabegron for medical expulsive therapy in ureteral calculi: A Systematic review and meta-analysis.

Introduction And Aim: The main categories of drugs employed for medical expulsive therapy in patients with ureteral calculi (UC) are alpha-blockers (α-B) and beta-adrenoceptor agonists. This meta-analysis evaluated the safety and effectiveness of α-B versus mirabegron (MIR) in treating UC.

Methods: From January 1980 to October 2024, we extensively searched the Pubmed, Web of science, Cochrane and EMBASE databases to identify randomized controlled trials (RCTs) that compared the effectiveness of α-B and MIR in managing UC.

First study on the efficiency of Tc-rituximab for sentinel lymph node mapping and biopsy in oral squamous cell carcinoma.

Objective: To explore the clinical efficiency of using the sentinel lymph node (SLN) imaging agent Tc-rituximab for lymphoscintigraphy and SLN biopsy (SLNB) in oral squamous cell carcinoma (OSCC) patients.

Methods: A retrospective study was conducted on 23 patients with OSCC who underwent Tc-rituximab lymphoscintigraphy and SLNB. The cohort comprised 16 men (69.

Intracellular and Extracellular Metabolic Response of the Lactic Acid Bacterium Under Salt Stress.

Background: is a member of the lactic acid bacterium group commonly found in many salt-fermented foods. Strains of isolated from high-salinity environments have been shown to tolerate salt stress to some extent. However, the specific responses and mechanisms of under salt stress are not fully understood.

Preparation of Patchouli Oil Microemulsion Gel and Its Topical Application to Ameliorate Atopic Dermatitis in Mice.

Patchouli oil (PO) is a natural substance famous for its immune-enhancing and anti-inflammatory effects. Atopic dermatitis (AD) is characterized by epidermal gene mutations, skin barrier dysfunction, and immune dysregulation, making patchouli volatile oil a potential candidate for AD treatment. Initially, PO was mixed with ethyl oleate (EO), castor oil ethoxylated ether-40 (EL-40), anhydrous ethanol, and water to form a patchouli oil microemulsion (PO-ME) system.

[Research progress on the effect of estuary microplastics on antibiotic resistance genes].

Estuaries are transitional zones between rivers and marine environments, with intensive human activities. Pollutants pose a threat to the ecological systems of estuaries. Among these pollutants, microplastics and antibiotic resistant genes have gained significant attention due to their potential impacts on estuarine organisms and human health.

Brg1 and RUNX1 synergy in regulating TRPM4 channel in mouse cardiomyocytes.

Background: Transient Receptor Potential Melastatin 4 (TRPM4), a non-selective cation channel, plays a critical role in cardiac conduction abnormalities. Brg1, an ATP-dependent chromatin remodeler, is essential for regulating gene expression in both heart development and disease. Our previous studies demonstrated Brg1 impacted on cardiac sodium/potassium channels and electrophysiological stability, its influence on TRPM4 expression and function remained unexplored.

Optimized automated radiosynthesis of F-JNJ64413739 for purinergic ion channel receptor 7 (P2X7R) imaging in osteoporotic model rats.

Objective: To optimize the automated radiosynthesis of the purinergic ion channel receptor 7 (P2X7R) imaging agent F-JNJ64413739 and evaluate its potential for brain imaging in osteoporotic model rats.

Methods: A more electron-deficient nitropyridine was employed as the labeling precursor to facilitate the F-labeling. The radiosynthesis was conducted on an AllinOne synthesis module, and followed by purification via high-performance liquid chromatography (HPLC).

Spatial variations of soil seed banks in Shanghai's urban wasteland: a gradient analysis of urbanization effects.

Urbanization greatly impacts both the diversity of soil seed banks and the spatial dynamics of species. These seed banks serve as a window into the ecological history and potential for recovery in urban wastelands, which are continually evolving due to urbanization. In this study, we selected 24 plots along urban-rural gradients in Shanghai, China.

CBL/Cbl-b mediates Fas degradation to reduce neuronal damage in experimental autoimmune encephalomyelitis.

Fas has been shown to positively regulate the differentiation of T helper 17 (Th17) cells in mouse models of experimental autoimmune encephalomyelitis (EAE). Fas protein expression is regulated by ubiquitination but has not been further studied. In this study, we investigated the role of the Fas ubiquitin ligase in Th17 cell differentiation and highlighted its potential as a therapeutic target for EAE.

WNT4 promotes the symmetric fission of crypt in radiation-induced intestinal epithelial regeneration.

Background: Radiotherapy for pelvic malignant tumors inevitably causes intestinal tissue damage. The regeneration of intestinal epithelium after radiation injury relies mainly on crypt fission. However, little is known about the regulatory mechanisms of crypt fission events.

HFM1 is essential for the germ cell intercellular bridge transport in primordial follicle formation in mice.

The reproductive lifespan of female mammals is determined by the size of the primordial follicle pool, which comprises oocytes enclosed by a layer of flattened pre-granulosa cells. Oocyte differentiation needs acquiring organelles and cytoplasm from sister germ cells in cysts, but the mechanisms regulating this process remain unknown. Previously helicase for meiosis 1 (HFM1) is reported to be related to the development of premature ovarian insufficiency.

Risk stratification based on changes in the standard maximal uptake value on PET/CT and the plasma Epstein‒Barr virus (EBV) DNA status after two cycles of chemotherapy for extranodal NK-/T-cell lymphoma.

Although different types of prognostic indices have been applied in extranodal NK-/T-cell lymphoma (ENKTL), they are based mainly on clinical characteristics before treatment. Moreover, these methods lack early assessment and tumor metabolic parameters. It remains unclear whether changes in the plasma Epstein-Barr virus DNA (EBVDNA) status and SUVmax after two cycles of chemotherapy may predict disease prognosis.

Correlation between Androgentic Alopecia and SARS-CoV-2 Omicron variant infection in China.

With the widespread prevalence of COVID-19, researches have suggested a potential link between androgens and COVID-19 outcomes. However, the relationship between COVID-19 and androgenetic alopecia (AGA)-a condition strongly influenced by androgens-remains controversial in existing studies. Notably, there is a lack of large-scale clinical studies, particularly concerning data on the Chinese population following infection with the Omicron variant.

Material Cycles, Environmental Emissions, and Ecological Risks of Bisphenol A (BPA) in China and Implications for Sustainable Plastic Management.

Bisphenol A (BPA) is a high-production-volume plastic chemical, with ∼98% of its usage in China allocated to producing polycarbonate and epoxy resin, and its fugitive release threatens ecosystems. However, knowledge of its anthropogenic cycles, environmental emissions, and ecological risks remains incomplete, hindering effective plastic lifecycle management. Herein, material flow analysis, multimedia environmental modeling, and ecological risk assessment were integrated to comprehensively map BPA dynamics in China.

ANCA-associated vasculitis presenting with progressive binocular manifestations: a case report and literature review.

This report primarily describes a rare case of an elderly male patient who initially presented with central retinal artery occlusion (CRAO) in the left eye and was ultimately diagnosed with anti-neutrophil cytoplasmic antibody (ANCA) -associated vasculitis involving the eyes, gastrointestinal tract, and kidneys. However, due to irregular treatment, both eyes developed progressive ocular manifestations later. This article emphasizes the importance of actively screening for and treating underlying conditions in cases of CRAO.

Pheochromocytoma in von Hippel-Lindau Disease: Clinical Features and Comparison With Sporadic Pheochromocytoma.

Objectives: Pheochromocytomas and paragangliomas (PPGLs) are manifestations of von Hippel-Lindau (VHL) disease. This study aims to describe the clinical features of PPGLs in VHL patients and the distinctions between VHL disease-related PPGLs and sporadic PPGLs.

Design, Patients And Measurements: The study included all patients with VHL disease and PPGLs treated in a single centre from 2007 to 2023.

Architecting Ultra-Robust Zr(IV) Metal-Organic Framework for Energy-Efficient Desiccant Air Conditioning.

Air-conditioning systems, composed mainly of humidity control and heat reallocation units, play a pivotal role in upholding superior air quality and human well-being across diverse environments ranging from international space stations and pharmacies to granaries and cultural relic preservation sites, and to commercial and residential buildings. The adoption of sorbent water as the working pair and low-grade renewable or waste heat in adsorption-driven air-conditioning presents a state-of-the-art solution, notably for its energy efficiency and eco-friendliness vis-à-vis conventional electricity-driven vapor compression cycles. Here, we introduce a rational π-extension strategy to engineer an ultrarobust and highly porous zirconium metal-organic framework (Zr-MOF).

Bletilla striata polysaccharide-mediated trained immunity drives the hematopoietic progenitors' expansion and myelopoiesis.

Trained immunity represents a functional state of the innate immune response, characterized by enduring epigenetic reprogramming of innate immune cells. This phenomenon facilitates a sustained and advantageous reaction of myeloid cells to subsequent challenges. Bletilla striata polysaccharide (BSP) is the primary active component of Bletilla striata, mainly consisting of mannose and glucose in its chemical structure.