Publications by authors named "Cui Xiao"

Kiwifruit (Actinidia chinensis), a recently commercialized horticultural crop, is rich in various nutrient compounds. However, the regulatory networks controlling the dynamic changes in key metabolites among different tissues remain largely unknown. Here, high-resolution spatiotemporal datasets obtained by ultraperformance liquid chromatography-tandem mass spectrometry methodology and RNA-seq were employed to investigate the dynamic changes in the metabolic and transcriptional landscape of major kiwifruit tissues across different developmental stages, including from fruit skin, outer pericarp, inner pericarp, and fruit core.

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Chlamydia psittaci is a zoonotic pathogen known to cause respiratory diseases in humans. Chlamydia infections are closely associated with apoptosis, in which miRNAs play regulatory roles. Herein, we demonstrated that C.

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Among type I photosensitizers, stable organic radicals are superior candidate molecules for hypoxia-overcoming photodynamic therapy. However, their wide applications are limited by complicated preparation processes and poor stabilities. Herein, a nitroxide radical was simply synthesized by introducing a commercially available "TEMPO" moiety.

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Article Synopsis
  • Rectal neuroendocrine neoplasms (rNENs) are common and challenging to manage, with tumor size being a key predictor of disease progression; however, the genetic changes in rNENs during their advancement are not well understood.
  • A study analyzed 54 pairs of rNEN tumors and normal tissues and found significant differences in mutations between small (≤2 cm) and large (>2 cm) tumors, with specific driver genes and pathways more prevalent in larger tumors, particularly those with lymph node metastases.
  • The research highlights defective DNA repair processes in larger rNENs with metastases, and most patients had genetic alterations that could inform targeted treatments, advancing the understanding of rNEN genetics and
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Background: Hospital-associated infection (HAI) is an important issue in intensive care units (ICUs). We still lack direct evidence on whether the ICU patients and/or the medical system can benefit from single isolated laminar-air-flow (LAF) wards.

Methods: High-touched-surface (HTS) swabs from 5 sites in two kinds of wards with different ventilation systems were longitudinally collected for 16 S rRNA sequencing and Type IIB restriction site-associated DNA sequencing for Microbiome (2bRAD-M).

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Background: Gastric adenocarcinoma of the fundic gland type (GA-FG) is a newly described variant of gastric adenocarcinoma with lack of knowledges regarding its genetic features.

Methods: We performed whole-genome sequencing (WGS) in formalin-fixed paraffin-embedded (FFPE) tumor tissues and matched adjacent noncancerous specimens from 21 patients with GA-FG, and integrated published datasets from 1105 patients with traditional gastric adenocarcinoma with the purpose of dissecting genetic determinants both common to conventional gastric adenocarcinoma and unique to GA-FG disease.

Results: We characterized the genomic architecture of GA-FG disease, revealing the predominant proportion of C > T substitution among the six types of SNVs.

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  • * Researchers applied this method to 453 samples from ICU patients, recovering high-quality genomes and identifying unique microbiome dynamics, dominant pathogens, and associations with antibiotic resistance.
  • * The findings highlight strain-specific traits among pathogens, potential inter-patient transmissions in ICUs, and an evolutionary landscape illustrating how microbial genetics can impact patient health outcomes.
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  • Fungal diseases, especially cobweb disease from the Hypocreaceae family, significantly affect the yield and quality of edible mushrooms.
  • The research details high-quality genome sequences of three cobweb fungi (Cb-Fv, CB-Ab, and CB-Mi), revealing important data about their evolutionary history and similarities.
  • Key genes related to pathogenicity, including CAZymes and proteases, were identified, providing critical insights that could help improve the control of cobweb disease and the overall quality of mushrooms.
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  • The study aimed to analyze changes in visual acuity in diabetic macular edema (DME) patients after anti-VEGF treatment, using the TCED-HFV optical coherence tomography (OCT) system for classification.
  • Medical records of patients were reviewed and categorized into four groups based on DME severity, comparing visual acuity and other clinical factors before and after treatment.
  • Results showed significant initial differences in visual acuity among groups, with improvements observed post-treatment, confirming the TCED-HFV OCT classification's effectiveness in assessing DME severity and treatment response.
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Background: The aggressive and refractory extranodal natural killer/T-cell lymphoma, nasal type (ENKTL-NT) is a subtype of non-Hodgkin's lymphoma. Succinylation promotes progression in a variety of tumors, but its mechanism in ENKTL-NT is unclear.

Methods: Bioinformatic analysis was performed to screen differentially expressed genes in the ENKTL dataset.

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Many different factors, such as species traits, socio-economic factors, geographical and environmental factors, can lead to specimen collection preference. This study aims to determine whether grassland specimen collection in China is preferred by species traits (i.e.

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Organic molecule-mediated noncanonical DNA self-assembly expands the standard DNA base-pairing alphabets. However, only a very limited number of small molecules have been recognized as mediators because of the tedious and complicated experiments like crystallization and microscopy imaging. Here we present an integrative screening protocol incorporating molecular dynamics (MD) for fast theoretical simulation and native polyacrylamide gel electrophoresis for convenient experimental validation.

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Background: Gastrointestinal (GI) function is critical for patients in intensive care units (ICUs). Whether and how much critically ill patients without GI primary diseases benefit from abdominal physical examinations remains unknown. No evidence from big data supports its possible additive value in outcome prediction.

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Article Synopsis
  • - The COVID-19 pandemic has highlighted the need for effective strategies to identify high-risk patients quickly, which can help optimize treatment and resource allocation for better outcomes in future pandemics.
  • - This study analyzed immune characteristics and developed machine learning models using data from several cohorts to differentiate between mild and critical COVID-19 cases based on immune signatures and laboratory parameters.
  • - Key findings revealed that critical COVID-19 patients showed a depletion of certain immune cells and elevated levels of specific inflammatory markers, with the developed models demonstrating strong accuracy in predicting illness severity across multiple cohorts.
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Objectives: This study aimed at identifying clinical and laboratory risk factors for myocardial involvement (MI) in idiopathic inflammatory myopathies (IIMs) patients as well as constructing a risk-predicted nomogram for prediction and early identification of MI.

Methods: An IIMs cohort in southeastern China was constructed, including 504 adult IIMs patients who met the inclusion and exclusion criteria, and were hospitalized at four divisions of the First Affiliated Hospital, Zhejiang University School of Medicine from January 1st 2018 to April 30st 2022. After dividing patients into the training cohort and the validation cohort, risk factors for MI were identified through least absolute shrinkage and selection operator regression and multivariate logistic regression.

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Objective: The primary objective of this comparative investigation was to examine the qualitative attributes of image reconstructions utilizing two distinct algorithms, namely OSEM and HYPER Iterative, in total-body 18F- FDG PET/CT under various acquisition durations and injection activities.

Methods: An initial assessment was executed using a NEMA phantom to compare image quality engendered by OSEM and HYPER Iterative algorithms. Parameters such as BV, COV, and CRC were meticulously evaluated.

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Unlabelled: is a highly successful pathogen that poses a substantial threat to human health. However, the dynamic interaction between and the human gastric epithelium has not been fully investigated. In this study, using dual RNA sequencing technology, we characterized a cytotoxin-associated gene A ()-modulated bacterial adaption strategy by enhancing the expression of ATP-binding cassette transporter-related genes, and , upon coculturing with human gastric epithelial cells.

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The dorsal striatum, an essential nucleus in subcortical areas, has a crucial role in controlling a variety of complex cognitive behaviors; however, few studies have been conducted in recent years to explore the functional subregions of the dorsal striatum that are significantly activated when performing multiple tasks. To explore the differences and connections between the functional subregions of the dorsal striatum that are significantly activated when performing different tasks, we propose a framework for functional division of the dorsal striatum based on a graph neural network model. First, time series information for each voxel in the dorsal striatum is extracted from acquired functional magnetic resonance imaging data and used to calculate the connection strength between voxels.

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Background: F-FDG positron emission tomography (PET) plays a crucial part in the evaluation for pediatric epileptic patients prior to therapy. Short-term scanning holds significant importance, especially for pediatrics epileptic individuals who exhibited involuntary movements. The aim was to evaluate the effects of short acquisition time on image quality and lesion detectability in pediatric epileptic patients using total-body (TB) PET/CT.

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Alcoholic liver disease (ALD) was the second leading cause of liver injury. Pursh (GHC) is an important ethnic drug of traditional Chinese medicine for the treatment of liver disease, but the pathogenesis is not clear. To analysis the intestinal microflora and metabolic pathway of GHC on ALD mice.

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A randomized, controlled clinical trial was conducted from 2022 to 2023 at a hospital specializing in Traditional Chinese Medicine in Shanghai. A total of 564 participants were allocated into control and intervention groups in order to determine the effectiveness of Shujing Tongdu massage on patients with chronic lesions or spinal disorders. No significant differences were observed in baseline characteristics between the groups; age, gender and condition type were all distributed in a comparable manner.

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Background: UV radiation exposure causes skin irritation, erythema, darkening and barrier disruption by inducing oxidative stress and inflammation. Glutathione, a master antioxidant, plays an important role in the antioxidant defence network of the skin.

Objective: This study aimed to assess the in vitro protective effects of the glutathione amino acid precursors blend (GAP) on transcriptomic and phenotypic endpoints against UVB-induced challenges.

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Background: Although glutathione (GSH) has long been considered a master antioxidant, poor stability and bioavailability limit its application in skin protection. To overcome the challenges, Unilever R&D formulated a Glutathione Amino acid Precursors blend (named GAP) to boost GSH de novo synthesis.

Objective: Determine whether GAP can boost GSH levels and provide skin protection against stressors.

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Pyroptosis is a gasdermins-mediated programmed cell death that plays an essential role in immune regulation, and its role in autoimmune disease and cancer has been studied extensively. Increasing evidence shows that various microbial infections can lead to pyroptosis, associated with the occurrence and development of microbial infectious diseases. This study reviews the recent advances in pyroptosis in microbial infection, including bacterial, viral, and fungal infections.

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