The association between abdominal obesity and pulmonary function trajectories among patients with COPD.

The association between abdominal obesity and pulmonary function trajectories among patients with COPD remain to be unclear. This study aimed to explore the association between abdominal obesity and pulmonary function trajectories among patients with COPD. Data were collected from the China Health and Retirement Longitudinal Study, which was a nationally representative investigation.

Hyaluronic Acid-Based Therapy for Alleviating Early Lipid Peroxidation in Peripheral Nerve Compression Injury Repair.

Background: Peripheral nerve injuries compromise sensory and motor functions, severely affecting patients' quality of life. Early lipid peroxidation drives oxidative stress, disrupting the regenerative microenvironment. Hyaluronic acid (HA), an essential extracellular matrix component, shows promise in mitigating oxidative damage and fostering repair.

Development of endolysin-integrated pH-responsive antiadhesive and antibacterial coatings with nanorods for the prevention of cross-contamination in fresh produce.

Cross-contamination is a major food safety risk during the harvesting and processing of fresh produce, leading to significant losses in global human well-being and the economy. The surface of food contact areas is a high-risk zone for cross-contamination. Therefore, developing an effective antimicrobial coating for food-contact surfaces is essential.

Novel strategies targeting mitochondria-lysosome contact sites for the treatment of neurological diseases.

Mitochondria and lysosomes are critical for neuronal homeostasis, as highlighted by their dysfunction in various neurological diseases. Recent studies have identified dynamic membrane contact sites between mitochondria and lysosomes, independent of mitophagy and the lysosomal degradation of mitochondrial-derived vesicles (MDVs), allowing bidirectional crosstalk between these cell compartments, the dynamic regulation of organelle networks, and substance exchanges. Emerging evidence suggests that abnormalities in mitochondria-lysosome contact sites (MLCSs) contribute to neurological diseases, including Parkinson's disease, Charcot-Marie-Tooth (CMT) disease, lysosomal storage diseases, and epilepsy.

Myelitis associated with glial fibrillary acidic protein IgG: characterization and comparison with aquaporin-4 IgG and myelin oligodendrocyte glycoprotein IgG myelitis.

Background: Awareness of the characteristics of glial fibrillary acidic protein autoantibody (GFAP-IgG) associated myelitis facilitates early diagnosis and treatment. We explored features in GFAP-IgG myelitis and compared them with those in myelitis associated with aquaporin-4 IgG (AQP4-IgG) and myelin oligodendrocyte glycoprotein IgG (MOG-IgG).

Methods: We retrospectively reviewed data from patients with GFAP-IgG myelitis at the First Affiliated Hospital of Zhengzhou University and Henan Children's Hospital from May 2018 to May 2023.

The effect of glass container surface silanol density on monoclonal antibody formulation stability after application of mechanical shock.

This study investigates the effect of silanol density on the surface of glass containers on the stability of monoclonal antibody (mAb) formulations subjected to mechanical stress. By calcining Type I glass containers at different temperatures, we altered the concentration of silanols on the glass surface and examined its impact on the stability of protein formulations under mechanical stress. Contact angle measurements and Fourier Transform Infrared (FTIR) spectroscopy indicated that silanol formation influences the hydrophilicity of the surface.

The influencing of obesity on lung ventilation function among middle-aged and elderly people.

This study examined the effect of obesity on lung ventilation function in middle-aged and older adults using data from the China Health and Retirement Longitudinal Study. Lung function was measured using peak expiratory flow, and obesity was assessed using waist circumference and body mass index (BMI). Logistic regression and the bivariate logit model were applied to analyze the data.

Analysis of imaging risk factors for prognosis in children with spinal cord injury without radiologic abnormalities.

This study aimed to identify imaging risk factors for spinal cord injury without radiologic abnormalities (SCIWORA) in children. We retrospectively analyzed the medical records and magnetic resonance imaging (MRI) findings of children with SCIWORA admitted to our hospital between January 1, 2012, and September 30, 2022. Univariate and binary logistic regression analyses were used to evaluate the prognostic impact of various factors including MRI type, maximum cross-sectional area of spinal cord injury, injury length, injury signal intensity ratio.

Isolation, identification, and pathogenicity evaluation of a novel Cluster 3 Tembusu virus isolated from geese in China.

Tembusu virus (TMUV) is a significant pathogen that poses a considerable threat to the waterfowl farming industry in China and is classified into three distinct genetic clusters. In 2024, a suspected outbreak of TMUV infection was reported at a goose farm in Guangdong Province, China. A strain of TMUV, designated GDE19-2024, was successfully isolated using chicken embryos.

Luminescent Fe(III) Complex Sensitizes Aerobic Photon Upconversion and Initiates Photocatalytic Radical Polymerization.

Light energy conversion often relies on photosensitizers with long-lived excited states, which are mostly made of precious metals such as ruthenium or iridium. Photoactive complexes based on highly abundant iron seem attractive for sustainable energy conversion, but this remains very challenging due to the short excited state lifetimes of the current iron complexes. This study shows that a luminescent Fe(III) complex sensitizes triplet-triplet annihilation upconversion with anthracene derivatives via underexplored doublet-triplet energy transfer, which is assisted by preassociation between the photosensitizer and the annihilator.

Maturational delay in the brainstem auditory pathway of very preterm babies with apnoea.

Aims: To assess the maturational status of the brainstem auditory pathway in babies with apnoea of prematurity (AOP) at 33-34 weeks of postmenstrual age (PMA), an important time landmark at which AOP is resolved in most cases.

Study Design: Compare brainstem auditory maturation between very preterm babies with AOP and those without AOP (non-AOP) at the same PMA 33-34 weeks to define differences.

Results: The AOP group showed significantly longer latencies of waves III and V latency than the non-AOP group (p < 0.

Establishment and Application of a New Radiation Biodosimetric Method Based on the Quantitative RPA-SHERLOCK Amplification Technology.

Biodosimetry is a key diagnostic tool for radiation exposure, risk assessment and treatment planning of acute radiation sickness. To effectively respond to a large-scale radiological incident, there is a need for the development of biodosimetric methods with fast, portable, and convenient operating advantages. We employed the recombinase polymerase amplification specific high-sensitivity enzymatic reporter unlocking (RPA-SHERLOCK) technology to establish a method for fast radiation dose assessment by measuring the expression level of radiation-inducible genes.

Trade-offs between Cd bioconcentration and translocation and underlying physiological and rhizobacterial mechanisms in Phragmites australis.

Cadmium (Cd) pollution poses a significant threat to wetland ecosystems. Phragmites australis, a species with intraspecific ploidy diversity, is commonly used in constructed wetlands for pollution remediation. However, little is known about how the ploidy variation of P.

Integrating subject-specific workspace constraint and performance-based control strategy in robot-assisted rehabilitation.

Introduction: The robot-assistive technique has been widely developed in the field of neurorehabilitation for enhancement of neuroplasticity, muscle activity, and training positivity. To improve the reliability and feasibility in this patient-robot interactive context, motion constraint methods and adaptive assistance strategies have been developed to guarantee the movement safety and promote the training effectiveness based on the user's movement information. Unfortunately, few works focus on customizing quantitative and appropriate workspace for each subject in passive/active training mode, and how to provide the precise assistance by considering movement constraints to improve human active participation should be further delved as well.

Organophosphorus Flame Retardants and Metabolic Disruption: An , , and Study Focusing on Adiponectin Receptors.

Background: Environmental chemical exposures have been associated with metabolic outcomes, and typically, their binding to nuclear hormone receptors is considered the molecular initiating event (MIE) for a number of outcomes. However, more studies are needed to understand the influence of such exposures on cell membrane-bound adiponectin receptors (AdipoRs), which are critical metabolic regulators.

Objective: We aimed to clarify the potential interactions between AdipoRs and environmental chemicals, specifically organophosphorus flame retardants (OPFRs), and the resultant effects.

Optimizing low-protein diets with edible dock powder: Integrated effects on growth performance, slaughter quality, Organ weights, Muscle quality, and Cecal microbiota in growing Sanhua geese.

This study evaluated the effects of supplementing low-protein diets with Edible Dock Powder (EDP) on the growth performance, slaughter traits, serum biochemical parameters, muscle quality, and cecal microbiota of Sanhua geese. A total of 288 healthy, five-week-old Sanhua geese were randomly assigned to six dietary treatments in a 3 × 2 factorial design, with three crude protein levels (16.00 %, 14.

Gait analysis in the early stage of Parkinson's disease with a machine learning approach.

Background: Gait disorder is a prominent motor symptom in Parkinson's disease (PD), objective and quantitative assessment of gait is essential for diagnosing and treating PD, particularly in its early stage.

Methods: This study utilized a non-contact gait assessment system to investigate gait characteristics between individuals with PD and healthy controls, with a focus on early-stage PD. Additionally, we trained two machine learning models to differentiate early-stage PD patients from controls and to predict MDS-UPDRS III score.

The Role of Human Adiponectin Receptor 1 in 2-Ethylhexyl Diphenyl Phosphate Induced Lipid Metabolic Disruption.

Epidemiological evidence links exposure to 2-ethylhexyl diphenyl phosphate (EHDPP) with lipid metabolic disruption, typically attributed to nuclear receptors, while the role of membrane receptors remains underexplored. This study explored the role of adiponectin receptor 1 (AdipoR1) in EHDPP-induced lipid metabolic disturbances. We examined EHDPP's binding affinity and transcriptional impact on AdipoR1.

Deferoxamine alleviates ferroptosis in seawater immersion combined with traumatic brain injury.

Traumatic brain injury (TBI) is a major cause of death and disability worldwide, with its severity potentially exacerbated by seawater immersion. Ferroptosis, a form of regulated cell death driven by iron-dependent lipid peroxidation, has been implicated in TBI pathogenesis. However, the specific occurrence and underlying mechanisms of ferroptosis in the context of TBI compounded by seawater immersion remain unclear.