Synergistic effects of anlotinib and DDP on breast cancer: targeting the VEGF/JAK2/STAT3 axis.

Background: Anlotinib, a highly selective inhibitor of VEGFR2, has demonstrated significant anti-tumor effects in various cancers. However, its potential synergistic effects with DDP (cisplatin) in breast cancer (BRCA) remain to be fully elucidated. This study aims to discover the therapeutic efficacy of anlotinib on BRCA, specifically the synergistic effects with DDP, and to elucidate the underlying molecular mechanisms.

How uncertainty in calibration data affects the modeling of non-point source pollutant loads in baseflow.

Baseflow is a major transport pathway for non-point source (NPS) pollutants. Watershed water quality (WWQ) models calibrated by low-quality data may produce misleading predictions of baseflow NPS pollutant loads, resulting in poor management decisions. We evaluated how models of the baseflow nitrate loads in the Huron River basin, southwest of Lake Erie, were affected by uncertainty in the calibration data.

Frustrated Lewis Pair Mediated f-p-d Orbital Coupling: Achieving Selective Seawater Oxidation and Breaking *OH and *OOH Scaling Relationship.

The development of oxygen evolution reaction (OER) electrocatalyst for seawater electrolysis plays a crucial role in producing renewable hydrogen energy. However, during the seawater electrolysis process, the anode inevitably undergoes chloride oxidation reaction (ClOR) due to Cl adsorption, making the seawater electrolysis process difficult to sustain. Inspired by the selective permeability of cell membranes, we propose a biomimetic design of frustrated Lewis pairs (FLPs) layers for selective seawater oxidation.

Carboxymethyl chitosan nanoparticle-modulated cationic hydrogels doped with copper ions for combating bacteria and facilitating wound healing.

The simultaneous administration of antibacterial treatment and acceleration of tissue regeneration are crucial for the effective healing of infected wounds. In this work, we developed a facile hydrogel (PCC hydrogel) through coordination and hydrogen interactions by polymerizing acrylamide monomers in the presence of carboxymethyl chitosan nanoparticles and copper ions. The prepared PCC hydrogel demonstrated effective bacterial capture from wound exudation and exhibited a potent bactericidal activity against methicillin-resistant (MRSA) and .

Developing an enhanced chimeric permuted intron-exon system for circular RNA therapeutics.

: Circular RNA (circRNA) therapeutics hold great promise as an iteration strategy in messenger RNA (mRNA) therapeutics due to their inherent stability and durable protein translation capability. Nevertheless, the efficiency of RNA circularization remains a significant constraint, particularly in establishing large-scale manufacturing processes for producing highly purified circRNAs. Hence, it is imperative to develop a universal and more efficient RNA circularization system when considering synthetic circRNAs as therapeutic agents with prospective clinical applications.

Preparation of Stainless Steel Superhydrophobic Surface and Analysis of Hydrophobic Mechanism.

By analyzing the application conditions of hydrothermal oxidation equipment, we found that the corrosion resistance of stainless steel is crucial. It is necessary to prepare superhydrophobic surface to improve the corrosion resistance and find a cost-effective and environmentally friendly preparation method. Therefore, this paper proposes a method combining nanosecond laser and post-treatment, which uses nanosecond laser to etch microstructure and reduces the surface energy through diverse post-treatment methods to achieve hydrophobicity.

Biotransformation and pharmacological activities of platycosides from roots.

In Northeast China, Goubao pickle is a popular food fermented from the roots of as the main material, offering a unique flavor and rich nutritional value. Platycosides in roots of may play a crucial role in determining the quality of Goubao pickle through microorganism fermentation. However, biotransfermation of platycosides has not been reviewed during fermentation.

AhR ligands from metabolites promote piglet intestinal ILC3 activation and IL-22 secretion to inhibit PEDV infection.

In maintaining organismal homeostasis, gut immunity plays a crucial role. The coordination between the microbiota and the immune system through bidirectional interactions regulates the impact of microorganisms on the host. Our research focused on understanding the relationships between substantial changes in jejunal intestinal flora and metabolites and intestinal immunity during porcine epidemic diarrhea virus (PEDV) infection in piglets.

Unraveling the Origin of Multichannel Circularly Polarized Luminescence in a Pyrene-Functionalized Topologically Chiral [2]Catenane.

Mechanically interlocked molecules (MIMs) are promising platforms for developing functionalized artificial molecular machines. The construction of chiral MIMs with appealing circularly polarized luminescence (CPL) properties has boosted their potential application in biomedicine and the optical industry. However, there is currently little knowledge about the CPL emission mechanism or the emission dynamics of these related MIMs.

CYTOR-NFAT1 feedback loop regulates epithelial-mesenchymal transition of retinal pigment epithelial cells.

Epithelial mesenchymal transition (EMT) occurring in retinal pigment epithelial cells (RPE) is a crucial mechanism that contributes to the development of age-related macular degeneration (AMD), a pivotal factor leading to permanent vision impairment. Long non-coding RNAs (lncRNAs) have emerged as critical regulators orchestrating EMT in RPE cells. In this study, we explored the function of the lncRNA CYTOR (cytoskeleton regulator RNA) in EMT of RPE cells and its underlying mechanisms.

Characteristics of second-hand exposure to aerosols from e-cigarettes: A literature review since 2010.

In recent years, the use of electronic vaping products (also named e-cigarettes) has increased due to their appealing flavors and nicotine delivery without the combustion of tobacco. Although the hazardous substances emitted by e-cigarettes are largely found to be much lower than combustible cigarettes, second-hand exposure to e-cigarette aerosols is not completely benign for bystanders. This work reviewed and synthesized findings on the second-hand exposure of aerosols from e-cigarettes and compared the results with those of the combustible cigarettes.

Review on toxicology and activity of tomato glycoalkaloids in immature tomatoes.

Owing to the lack of selection and limited intelligence in mechanical picking, some immature tomatoes that contain alkaloids are thrown away. Tomatine alkaloids are steroidal alkaloids naturally present in Solanaceae plants, which are distributed in small amounts in immature tomato fruits and decrease as the fruits ripen. Tomato glycoalkaloids are harmful to human health.

Analysis of scanning systematic errors for airborne laser bathymetry.

For the Palmer mechanical scanning pattern of an airborne laser bathymetry system, the potential errors of the scanning system are analyzed, and the associated error model is derived. The model composes the description of laser rays, water surface fluctuations, and refraction, and introduces certain simplifications concerning the water surface and column. Based on the scanning error model, the impact of each error source on the vertical and horizontal positioning accuracy is investigated and established through a numerical simulation.

PM exposure and spatial transmission of nicotine from the simulated second-hand vapor of pod-based electronic cigarettes.

Electronic cigarettes (E-cigarettes) have gained significant popularity in recent years as a substitute for combustible cigarettes. However, there is growing concern regarding the safety of E-cigarette products for both the users and those exposed passively to second-hand emissions, which contain nicotine and other toxic substances. In particular, the characteristics of second-hand PM exposure and the transmission of nicotine from E-cigarettes remain unclear.

Identification and functional characterization of caspases in turbot (Scophthalmus maximus) in response to bacterial infection.

Apoptosis is the autonomous and orderly death of cells under genetic control to maintain the stability of the internal environment, and is a programmed cell death process with unique morphological and biochemical properties that is regulated by a variety of factors. Caspase gene family has a significant function in the process of apoptosis. However, the knowledge of caspases in turbot remains largely unknown.

Non-monotonic changes in Asian Water Towers' streamflow at increasing warming levels.

Previous projections show consistent increases in river flows of Asian Water Towers under future climate change. Here we find non-monotonic changes in river flows for seven major rivers originating from the Tibetan Plateau at the warming levels of 1.5 °C, 2.

Genome-wide identification and functional characterization of inhibitor of nuclear factor-κB (IκB) kinase (IKK) in turbot (Scophthalmus maximus).

The inhibitor of nuclear factor-κB (IκB) kinase (IKK) is involved in a variety of intracellular cell signaling pathways and is an important component of the NF-κB signaling pathway. IKK genes have been suggested to play important roles in the innate immune response to pathogen infection in both vertebrates and invertebrates. However, little information is available about IKK genes in turbot (Scophthalmus maximus).

Serum uric acid is related to left ventricular geometry and function in patients with obstructive sleep apnea.

Introduction: Serum uric acid (SUA) is an oxidative stress-related biomarker of cardiovascular risk. We sought to discover whether or not SUA was related to left ventricular geometry (LVG) and function among individuals with obstructive sleep apnea (OSA).

Methods: Patients with OSA and healthy controls were assessed for clinical features, echocardiography, polysomnography, and blood biochemical data.

Functional features in patients with idiopathic macular hole treatment via OCT angiography.

To evaluate the optical coherence tomography (OCT) angiography features in patients with idiopathic macular hole (IMH) before and after vitrectomy. This prospective study included 25 patients diagnosed with IMH in Shanxi eye hospital from August 2019 to December 2021. The study was divided into 3 groups: IMH eyes, fellow eyes and normal eyes.

Inflammatory cytokines and their correlations with different left ventricular geometries and functions in PHT patients.

Objectives: To investigate relationships between hypersensitive C-reactive protein (hs-CRP), tumor necrosis factor -α (TNF-α), interleukin-17A (IL-17A), and interferon -γ (IFN-γ), with left ventricular geometry (LVG) and function in patients with primary hypertension (PHT).

Methods: A total of 396 PHT patients were assigned into four groups: Normal Geometry (NG), Concentric Remodeling (CR), Eccentric Hypertrophy (EH), and Concentric Hypertrophy (CH). The correlation between hs-CRP, TNF-α, IL-17A, IFN-γ, and clinical, biochemical parameters were analyzed by Pearson correlation analysis and Logistic regression.

Arbitrary-Order and Multichannel Optical Vortices with Simultaneous Amplitude and Phase Modulation on Plasmonic Metasurfaces.

The highly localized and uneven spatial distribution of the subwavelength light field in metal metasurfaces provides a promising means for the generation of optical vortices (OVs) with arbitrary topological charges. In this paper, a simple and reliable way for generating multichannel OVs on gold nanoporous metasurfaces is reported. The instantaneous field of arbitrary-order OVs can be regulated and concentrated on the same focal surface by adapting photonic spin-orbit interaction (SOI) and geometric phase.

Alleviation of Oxidative Damage Induced by CaCl Priming Is Related to Osmotic and Ion Stress Reduction Rather Than Enhanced Antioxidant Capacity During Germination Under Salt Stress in Sorghum.

Seed germination is the sensitive period to salt stress. Calcium chloride (CaCl) has been proved as an effective priming agent which can promote the sorghum germination under salt stress. However, there are few reports on CaCl priming to improve the salt tolerance during seed germination.

Morphological and Functional Features in Patients with Idiopathic Macular Hole Treatment.

Purpose: To evaluate the multifocal electroretinogram (mfERG) and optical coherence tomography (OCT) angiography features in patients with idiopathic macular hole (IMH) before and after vitrectomy.

Patients And Methods: This prospective study was conducted at Shanxi Eye Hospital from January 2019 to December 2021. Twenty-five eyes of 25 patients with unilateral IMH, the unaffected fellow eyes, and 30 eyes of healthy patients were investigated.

Effects of high serum uric acid levels on oxidative stress levels and semen parameters in male infertile patients.

This study is to investigate the effect of high serum uric acid (UA) level on oxidative stress and semen quality of male infertility patients.A cohort of 654 male individuals aged between 20 and 45 years old were included in this study, and their semen and venous blood samples were collected. The serum UA, blood glucose, blood lipids, and hormone levels were determined by chemiluminescence method.