Acetylation of E2F1 at K125 facilitates cell apoptosis under serum stress.

E2F1 is a critical transcription factor that regulates cell cycle progression, is expressed at high levels in most cancer cells, and activates the biogenesis of proteins related to the cell cycle. Over recent years, researchers have demonstrated that E2F1 could also facilitate cellular apoptosis under conditions of cellular stress, thus creating a double-edged sword associated with both the regulation of cellular survival and death. However, the mechanisms responsible for these actions remain poorly understood.

One-Pot Synthesis of Oxygen Vacancy-Rich Amorphous/Crystalline Heterophase CaWO Nanoparticles for Enhanced Radiodynamic-Immunotherapy.

Radiodynamic therapy that employs X-rays to trigger localized reactive oxygen species (ROS) generation can tackle the tissue penetration issue of phototherapy. Although calcium tungstate (CaWO) shows great potential as a radiodynamic agent benefiting from its strong X-ray absorption and the ability to generate electron-hole (e-h) pairs, slow charge carrier transfer and fast e-h recombination greatly limit its ROS-generating performance. Herein, via a one-pot wet-chemical method, oxygen vacancy-rich amorphous/crystalline heterophase CaWO nanoparticles (Ov-a/c-CaWO NPs) with enhanced radiodynamic effect are synthesized for radiodynamic-immunotherapy of cancer.

3D-Printed Hydrogel Scaffolds Loaded with Flavanone@ZIF-8 Nanoparticles for Promoting Bacteria-Infected Wound Healing.

Bacterial-infected skin wounds caused by trauma remain a significant challenge in modern medicine. Clinically, there is a growing demand for wound dressings with exceptional antibacterial activity and robust regenerative properties. To address the need, this study proposes a novel multifunctional dressing designed to combine efficient gas exchange, effective microbial barriers, and precise drug delivery capabilities, thereby promoting cell proliferation and accelerating wound healing.

Trehalose and Mannitol Based Lyoprotetion of Taq DNA Polymerase for Cold-chain-free Long-term Storage.

Polymerase chain reactions (PCR) are most reliable and precise means for nucleic acid analysis of biological samples. A cold-chain system with temperature at around -20°C is generally necessary for storage and transportation of PCR-related reagents. In order to facilitate ambient temperature storage and transportation, this study prepared Taq DNA polymerase and 5 × HS-Taq Mix (as low as 0.

Kinetics and Oligomer Products of the Multiphase Reactions of Hydroxyacetone with Atmospheric Amines, Ammonium Sulfate, and Cloud Processing.

Hydroxyacetone (HA) is an atmospheric oxidation product of isoprene and other organic precursors that can form brown carbon (BrC). Measured bulk aqueous-phase reaction rates of HA with ammonium sulfate, methylamine, and glycine suggest that these reactions cannot compete with aqueous-phase hydroxyl radical oxidation. In cloud chamber photooxidation experiments with either gaseous or particulate HA in the presence of the same N-containing species, BrC formation was minor, with similar mass absorption coefficients at 365 nm (<0.

Associations between phthalate metabolites and body composition in children aged 8-19 years.

This study aimed to determine the relationship between individual and combined phthalate metabolites and body composition in children and adolescents using data from the 2015-2018 National Health and Nutrition Examination Survey. Single-exposure analysis indicated that most phthalate metabolites were negatively correlated with areal bone mineral density (aBMD). Quantile g-computation demonstrated a negative relationship between the mixture of phthalate metabolites and aBMD, which was confirmed by the Bayesian kernel machine regression model.

Investigation of the Potential Material Basis and Mechanism of Astragali Radix Against Adriamycin-Induced Nephropathy Model Rat by H NMR and MS-Based Untargeted Metabolomics Analysis.

Astragali Radix (AR) is one of the monarch drugs of Fangji Huangqi decoction and has the effects of inducing diuresis to alleviate edema, tonifying and strengthening the body. However, there is a paucity of research regarding the effective fraction and the underlying metabolic mechanism of AR on nephrotic syndrome (NS). This work aims to elucidate the potential mechanisms of AR treating NS, as well as to identify effective part and components.

A bacterial methyltransferase that initiates biotin synthesis, an attractive anti-ESKAPE druggable pathway.

The covalently attached cofactor biotin plays pivotal roles in central metabolism. The top-priority ESKAPE-type pathogens, and , constitute a public health challenge of global concern. Despite the fact that the late step of biotin synthesis is a validated anti-ESKAPE drug target, the primary stage remains fragmentarily understood.

The Predictive Value of Preoperative Systemic Immune-Inflammation Index in Patients with Granulomatous Mastitis.

Purpose: The systemic immune-inflammation index (SII) comprehensively reflects the balance between immune status and host inflammation. We aimed to investigate the potential predictive value of the SII in the prognosis of granulomatous mastitis (GM).

Patients And Methods: We enrolled 245 patients with GM who underwent surgery between 2015 and 2020 in this study.

Non-contrast MRI based machine learning and radiomics signature can predict the severity of primary lower limb lymphedema.

Purpose: According to International Lymphology Society guidelines, the severity of lymphedema is determined by the difference in volume between the affected limb and the healthy side divided by the volume of the healthy side. However, this method of measuring volume is time-consuming, laborious, and has certain errors in clinical applications.Therefore, this study aims to explore whether machine learning radiomics features based on non-contrast magnetic resonance imaging (NCMRI) can predict the severity of primary lower limb lymphedema.

A STT3A-dependent PD-L1 glycosylation modification mediated by GMPS drives tumor immune evasion in hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) is a malignant tumor characterized by rapid progression. To explore the regulatory mechanism of rapid tumor growth and metastasis, we conducted proteomic and scRNA-Seq analyses on advanced HCC tissues and identified a significant molecule, guanine monophosphate synthase (GMPS), closely associated with the immune evasion in HCC. We analyzed the immune microenvironment characteristics remodeled by GMPS using scRNA-Seq and found GMPS induced tumor immune evasion in HCC by impairing the tumor-killing function of CD8  T cells.

Nondestructive Analysis of Commercial Batteries.

Electrochemical batteries play a crucial role for powering portable electronics, electric vehicles, large-scale electric grids, and future electric aircraft. However, key performance metrics such as energy density, charging speed, lifespan, and safety raise significant consumer concerns. Enhancing battery performance hinges on a deep understanding of their operational and degradation mechanisms, from material composition and electrode structure to large-scale pack integration, necessitating advanced characterization methods.

Novel PNPLA8 variants associated with primary ovarian insufficiency, tremors, cerebellar ataxia and limb weakness: a case report and literature review.

Background: PNPLA8 is a gene that causes an autosomal recessive mitochondrial disease characterised by microcephaly and intractable epilepsy in infants and cerebellar ataxia and limb weakness in adults. Herein, we report the clinical, muscle pathology, and brain imaging features of an adult patient with new variants of PNPLA8.

Methods: A 27-year-old Chinese woman presented with abnormal gait at age 11, remained amenorrhoeic with an infantile uterus at age 17, and presented with head and limb tremors at age 21.

Polycyclic aromatic hydrocarbons exposure in early pregnancy on child neurodevelopment.

The epidemiological evidence from studies on the impact of exposure to polycyclic aromatic hydrocarbons (PAHs) during pregnancy on child neurodevelopment is inconclusive. This study aimed to assess the associations of PAHs exposure in early pregnancy and neurodevelopmental outcomes in children aged 6-12 months in a prospective cohort. In this study, we included 172 mother-child pairs with complete data in Tianjin City, China.

Continuously tunable low-loss phase shifter using weak-dispersion spoof surface plasmon polaritons.

We propose a continuously tunable low-loss phase shifter based on weak-dispersion spoof surface plasmon polariton (SSPP) waveguide. Unlike traditional designs of SSPP devices that rely on the strong-dispersion property, we address the high insertion loss issue by leveraging the weak-dispersion region of SSPP. A detailed study reveals the relation between the waveguide length, phase shift, and insertion loss of SSPP.

Design of intelligent human-machine collaborative robot-assisted craniotomy system.

Objectives: To develop an intelligent human-machine collaborative control robot-assisted craniotomy system, and test its efficacy by experiments.

Methods: The system integrated a UR5 robotic arm (Universal Robots, Denmark), a host computer, a double six-degree-of-freedom force sensor(Nanjing Yuli Instrument Co., Ltd.

Taloring sawdust derived hydrochar via red mud for cadmium removal: Electron transfer insight and recyclability assessment.

Iron modified bio-adsorbents gained a lot of attention recently, especially some iron-contain wastes were employed for fabrication. However, the influence of indigenous impurities in wastes was merely investigated. In this study, red mud (RM), an iron-rich by-product was employed as source to prepare Fe modified hydrochar (RM@HC) by a facile hydrothermal method, and then employed for Cd(II) removal from wastewater.

A green and efficient method for detecting nicosulfuron residues in field maize using hyperspectral imaging and deep learning.

Accurate and rapid detection of nicosulfuron herbicide residues in field-grown maize is essential for implementing chemical remediation and optimizing spraying strategies. However, current detection methods are costly and time-consuming. This study analyzed residue levels in six maize varieties-both resistant and sensitive types-under two herbicide concentrations, categorizing residues into low, medium, and high levels.

A study of the changing characteristics and influencing factors of holiday visitor vitality in Urban parks: The case of Fuzhou, China.

The vitality of urban parks reflects the intensity of green space utilization, gauging visitors' overall perception of the parks, facilitating integrated park management, and ensuring the parks' sustainable development. But, the park's spatial vitality characteristics change over time, and the factors influencing the differences in vitality have not been conclusively established. Therefore, This study employs Baidu heat map data to examine the spatial and temporal distribution patterns of park visitor vitality on holidays and weekdays in urban parks located in the core urban region of Fuzhou City.

Programmable topological metasurface to modulate spatial and surface waves in real time.

We propose a programmable topological metasurface to integrate intelligent modulations of spatial and surface waves. A general design method is presented to design the programmable metasurface elements with PIN diodes. The surface waves can be controlled to propagate along the topological domain-wall interface by programming the C-symmetry elements, while the spatial waves are modulated by the patterns of C-symmetry elements.

Language-controllable programmable metasurface empowered by large language models.

Programmable metasurface has become a prominent tool in various areas including control, communication, computing, and so on, due to its unique capability in the electromagnetic (EM) manipulation. However, it is lack of the intelligence in the sense that it usually requires the manual intervention, and thus makes it hard to behavior as the human process. To endow the programmable metasurface with the intelligence, we here proposed the concept of the language-controllable programmable metasurface for autonomous EM manipulations by exploring the notable capability of large language models (LLMs) in attaining the human-like intelligence.

Competence and Training Needs in Infectious Disease Emergency Response Among Chinese Nurses: Cross-Sectional Study.

Background: In recent years, the frequent outbreaks of infectious diseases and insufficient emergency response capabilities, particularly issues exposed during the COVID-19 pandemic, have underscored the critical role of nurses in addressing public health crises. It is currently necessary to investigate the emergency preparedness of nursing personnel following the COVID-19 pandemic completely liberalized, aiming to identify weaknesses and optimize response strategies.

Objective: This study aimed to assess the emergency response competence of nurses, identify their specific training needs, and explore the various elements that impact their emergency response competence.