Publications by authors named "Cui LiangLiang"

Photonic crystal hydrogels (PCHs) are innovative materials that translate imperceptible deformations and humidity changes into visible colors, broadening the applications of photonics in bioengineering and smart materials. To overcome poor mechanical properties of traditional PCHs limited by weak intermolecular forces, we designed a PCH with a dual-network framework comprising N-isopropylacrylamide-co-acrylamide (NIPAM-co-AM) and biomass lotus root starch (LR). Since LR is rich in hydroxyl groups, it can undergo molecular linkage entanglement with the NIPAM-co-AM hydrogel matrix, forming hydrogen bonds that significantly enhance the mechanical properties of the PCH.

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Solid fuel combustion exposure is a leading global health risk factor, yet evidence on its effects, especially on vulnerable children, is sparse. This large-scale, multi-center prospective study aimed to address this gap by involving 9997 schoolchildren across China between 2013 and 2015. Here we show that lung function levels exhibited a marginally significant decline among children exposed to solid fuel usage.

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  • The study introduces a new freeze-resistant conductive hydrogel called PHEA-NaSS/G, which maintains its properties in extreme environments by modifying hydrogen bonds through a special solvent system.
  • This hydrogel boasts impressive mechanical strength (174 kPa) and flexibility (2105% strain), making it suitable for monitoring human motion and demonstrating excellent sensing capabilities.
  • Additionally, it can accurately recognize handwritten English letters using advanced algorithms, suggesting valuable applications in areas like soft robotics and health monitoring.
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  • Hydrogels are essential for wearables due to their flexibility and sensitivity, but they challenge to maintain efficiency under varying humidity and temperature.
  • A dual network hydrogel using tannic acid, polyacrylamide, and sodium carboxymethylcellulose was developed, enhanced with green solvents for improved water retention and mechanical consistency.
  • The composite hydrogel exhibits long-term stability and high sensitivity as a strain sensor, making it suitable for smart flexible electronics in tough environmental conditions.
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What Is Already Known About This Topic?: The mortality rate due to pneumonia varies depending on the infectious agents present in a low- temperature environment.

What Is Added By This Report?: This study aimed to examine the relationship between low temperatures and cold waves and the risk of mortality from infectious pneumonia in the elderly. The findings indicate a significant increase in the risk of infectious pneumonia, specifically bacterial pneumonia, during periods of low temperatures and cold waves.

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  • This study investigates the impact of inland typhoon Lekima on the acute death risk in Jinan, highlighting that previous research largely overlooked inland effects compared to coastal areas.
  • During the typhoon month, Jinan saw 3,366 deaths, with increased risks particularly for older adults and women, particularly from circulatory diseases in the weeks following the storm.
  • The findings suggest that residents' vulnerability heightened significantly from the seventh day after the typhoon, indicating a need for targeted interventions for at-risk populations.
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Background: Constrained by no proper way to assess cumulative exposure, the joint effect of air pollution cumulative exposure doses on childhood asthma and wheezing (AW) was not understood.

Objective: To assess the association between cumulative exposure to multiple air pollutants in early life and childhood AW.

Methods: We designed a nested case-control study based on the birth cohort in Jinan City.

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What Is Already Known About This Topic?: Studies have extensively documented the separate and independent effects of extreme temperature and ozone on morbidity and mortality associated with respiratory and circulatory diseases.

What Is Added By This Report?: The study revealed a significant association between elevated temperature, ozone pollution, and the combined effect of high temperature and ozone pollution with an increased risk of all-cause medical emergency calls (MECs) and MECs specifically related to neurological diseases.

What Are The Implications For Public Health Practice?: Interventional measures should be implemented to mitigate exposure to high temperatures and ozone levels.

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Background: Ischemic cerebral infarction is one of cerebrovascular diseases with high incidence, disability rate, and mortality globally, and neuronal cell apoptosis is a crucial cause of brain injury during cerebral infarction.

Methods: A middle cerebral artery occlusion (MCAO) model was built in Sprague-Dawley rats to simulate ischemic cerebral infarction. An in vitro model of ischemic cerebral infarction was constructed in BV2 cells with the treatment of oxygen-glucose deprivation (OGD).

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  • The heat health early warning model is an effective tool for reducing health risks from heatwaves and enhancing population resilience, primarily utilized in high-income countries.
  • The graded heat health risk early warning model (GHREWM) in Jinan City has proven effective in protecting vulnerable groups, preventing an estimated 10.9 deaths per million and saving roughly 227 million CNY during the summer of 2022.
  • For better public health outcomes, it's essential to include more health endpoint data in early warning models to improve their effectiveness against climate-related health risks.
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  • * Using emergency call data from 2013 to 2020, researchers applied statistical methods to assess the acute impact of cold wave days on CO poisoning, revealing that lower temperature thresholds significantly elevate the risk.
  • * The findings indicate a clear link between cold waves and increased CO poisoning risk, emphasizing the need for timely cold wave warnings and protective measures to safeguard public health.
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  • The study aimed to investigate how maternal temperature exposure (AT) during pregnancy affects the risk of childhood asthma and wheezing in young children aged 18 months to 3 years.
  • A cross-sectional study screened 12,384 vaccinated children, identifying 236 cases of asthma and wheezing, and further analyzed associations using advanced statistical models.
  • Results revealed significant links between cold exposure in the first trimester and both cold and heat exposure in the third trimester, especially affecting girls and children living near busy roads or with parents who have asthma.
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Background: Given differences in vulnerability of children in early life, a life course approach to asthma and wheezing (AW) in young children caused by ozone (O) is not fully understood.

Methods: We conducted a birth cohort in Jinan, China from 2018 to 2021 to elucidate the onset model of childhood AW due to O exposure. An inverse distance weighted model was used for individual exposure assessment.

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Carbon monoxide (CO) poisoning is a public health concern in developing countries especially in China with a high disease burden. We aimed to focus on non-occupational CO poisoning caused by household coal heating secular trends based on registry data in Jinan, China, and we aim to provide further evidence and suggestions for public health policy. We analyzed the occurrence and development trend and assess the spatial-temporal epidemiological characteristics of non-occupational CO poisoning caused by household coal heating in Jinan between 2007 and 2021.

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  • The study investigates the impact of extreme cold weather on circulatory disease mortality among older adults in Jinan, analyzing data from 2011 to 2020 to identify vulnerable populations.
  • Using a case-crossover method, results showed a significant increase in circulatory disease deaths, particularly during defined cold days and cold waves, with older adults totaling 92,119 deaths in the study period.
  • Findings revealed that extreme cold weather has a more pronounced effect on women and older age groups, emphasizing the need for targeted public health policies to address this issue.
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  • Recent studies suggest that particulate matter (PM) exposure may trigger the hypothalamus-pituitary-adrenal (HPA) axis through hormonal changes, increasing risks for neurological and cardiovascular issues.
  • The research found a connection between PM and gut microbiota, indicating a potential pathway for how PM could impact health through the gut-brain axis (GBA).
  • A study in Jinan, China showed that PM exposure correlated with elevated levels of stress hormones and negative changes in gut microbiota, leading to increased anxiety and higher levels of blood glucose and cholesterol.
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  • - Insulin resistance (IR) is linked to type 2 diabetes and can be influenced by exposure to fine particle air pollution, with potential mechanisms including inflammation, oxidative stress, and gut microbiota imbalance.
  • - A study involving 76 healthy seniors examined the relationship between air pollution exposure and various health indicators like blood glucose, insulin levels, and inflammation markers, using advanced statistical models.
  • - Results showed that higher exposure to fine particles was associated with increased IR and inflammation, suggesting that air pollution may negatively impact metabolism through systemic inflammation and alterations in sphingolipid metabolism.
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Epidemiological studies show strong associations between fine particulate matter (PM) air pollution and adverse pulmonary effects. In the present study, wintertime PM samples were collected from three geographically similar regions-Sacramento, California, USA; Jinan, Shandong, China; and Taiyuan, Shanxi, China-and extracted to form PM, PM, and PM, respectively, for comparison in a BALB/c mouse model. Each of four groups was oropharyngeally administered Milli-Q water vehicle control (50 μL) or one type of PM extract (20 μg/50 μL) five times over two weeks.

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  • Vaccination has not fully eliminated mumps as a public health issue in countries like China, leading researchers to study how local meteorological factors, such as temperature, humidity, and wind speed, influence mumps cases in Jinan from 2014 to 2018.
  • The study found a non-linear increase in mumps risk with rising weekly temperatures, particularly between 1.2 and 24.5 °C, indicating a 3.08% increase in cases for each 1 °C rise at no lag time, with effects lasting up to 3 weeks.
  • Interactions between temperature and relative humidity or wind speed were significant, suggesting that the risk of mumps increases under specific meteorological conditions, highlighting the
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  • Long-term exposure to fine particulate matter (PM) is linked to kidney issues, but this study focuses on short-term effects of specific PM elements on kidney function.
  • The research involved 71 older adults who wore PM monitors, completed questionnaires, and underwent health exams to assess their kidney function using estimated glomerular filtration rate (eGFR).
  • Findings showed that increases in certain PM elements (like copper, manganese, and titanium) over short periods were associated with significant drops in eGFR, indicating potential harm to kidney function in older individuals.
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China has made great efforts in air pollution control since 2013. However, there is a lack of evaluation of environmental, health and economic co-benefits associated with the national and local air pollution control measures at a city level. We analyzed local air pollution control policies and implementation in Jinan, one of the most heavily air-polluted cities in China between 2013 and 2017.

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  • A study was conducted in Jinan, China, involving 67 elderly residents to measure personal black carbon (BC) exposure and identify factors influencing it.
  • Personal BC exposure was monitored using portable devices, revealing an average concentration of 4.1 μg/m, which was slightly lower than the ambient level of 4.6 μg/m.
  • Key factors affecting personal exposure included ambient BC concentration, temperature, humidity, education level, and use of air purifiers, emphasizing the importance of assessing individual exposure for health risk evaluations.
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Background: Primary drug-resistant tuberculosis (DR-TB) has contributed to a significant health and economic burden on a global scale, especially in China. we sought to estimate epidemiological characteristics of primary DR-TB in China from 2004 to 2018.

Methods: Eleven thousand four hundred sixty-seven newly diagnosed and 1981 retreated TB cases with drug susceptibility data were included.

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