Step forward: implementation and evaluation of STEPS program to optimize postpartum hemorrhage management in vaginal deliveries.

Background: Postpartum hemorrhage (PPH) is a leading cause of maternal mortality worldwide, particularly in resource-limited settings. Enhancing maternal safety in relation to PPH requires optimizing care protocols, continuous monitoring, and timely interventions. However, integrating these methodologies into vaginal delivery practices remains underexplored.

Development of a humanoid robot control system based on AR-BCI and SLAM navigation.

Brain-computer interface (BCI)-based robot combines BCI and robotics technology to realize the brain's intention to control the robot, which not only opens up a new way for the daily care of the disabled individuals, but also provides a new way of communication for normal people. However, the existing systems still have shortcomings in many aspects such as friendliness of human-computer interaction, and interaction efficient. This study developed a humanoid robot control system by integrating an augmented reality (AR)-based BCI with a simultaneous localization and mapping (SLAM)-based scheme for autonomous indoor navigation.

[A review of functional electrical stimulation based on brain-computer interface].

Individuals with motor dysfunction caused by damage to the central nervous system are unable to transmit voluntary movement commands to their muscles, resulting in a reduced ability to control their limbs. However, traditional rehabilitation methods have problems such as long treatment cycles and high labor costs. Functional electrical stimulation (FES) based on brain-computer interface (BCI) connects the patient's intentions with muscle contraction, and helps to promote the reconstruction of nerve function by recognizing nerve signals and stimulating the moving muscle group with electrical impulses to produce muscle convulsions or limb movements.

Enhancement of Hybrid BCI System Performance Based on Motor Imagery and SSVEP by Transcranial Alternating Current Stimulation.

The hybrid brain-computer interface (BCI) is verified to reduce disadvantages of conventional BCI systems. Transcranial electrical stimulation (tES) can also improve the performance and applicability of BCI. However, enhancement in BCI performance attained solely from the perspective of users or solely from the angle of BCI system design is limited.

Effects of tranexamic acid preconditioning on the incidence of postpartum haemorrhage in vaginal deliveries with identified risk factors in China: a prospective, randomized, open-label, blinded endpoint trial.

Objective: This study aimed to evaluate the effects of tranexamic acid (TXA) in preventing postpartum haemorrhage (PPH) among women with identified risk factors for PPH undergoing vaginal delivery in China.

Methods: This prospective, randomized, open-label, blinded endpoint (PROBE) trial enrolled 2258 women with one or more risk factors for PPH who underwent vaginal delivery. Participants were randomly assigned in a 1:1 ratio to receive an intravascular infusion of 1 g TXA or a placebo immediately after the delivery of the infant.

Prolonged second stage of labor and risk of postpartum hemorrhage in nullipara with epidural anesthesia and vaginal delivery: A cohort study with propensity score analysis.

Objective: To conduct an analysis using propensity score methods, exploring the association between a prolonged second stage (>3 h) and the risk of postpartum hemorrhage (PPH) in a diverse population.

Methods: We conducted a prospective cohort study involving nullipara with epidural anesthesia and vaginal delivery, aged ≥18 years, presenting cephalically, and with a gestational age (GA) of ≥24 weeks at a tertiary maternity hospital in China (chictr.org.

Novel biomarkers for prediction of atonic postpartum hemorrhage among 'low-risk' women in labor.

Background: Postpartum hemorrhage (PPH) is the primary cause of maternal mortality globally, with uterine atony being the predominant contributing factor. However, accurate prediction of PPH in the general population remains challenging due to a lack of reliable biomarkers.

Methods: Using retrospective cohort data, we quantified 48 cytokines in plasma samples from 40 women diagnosed with PPH caused by uterine atony.

Triple-transformable dynamic surroundings for programmed transportation of bio-vulnerable mRNA payloads towards systemic treatment of intractable solid tumors.

The surface physiochemical properties of nanomedicine play a crucial role in modulating biointerfacial reactions in sequential biological compartments, accordingly accomplishing the desired programmed delivery scenario to intracellular targets. PEGylation, which involves modifying the surface with a layer of poly(ethylene glycol), has been validated as an effective strategy for minimizing adverse biointerfacial interactions. However, it has also been observed to impede cellular uptake and intracellular trafficking activities.

Synthetic genomic nanomedicine with triple-responsiveness for systemic anti-tumor therapy.

To overcome the biological barriers in the journey of systemic gene delivery, a multifaceted genomic synthetic nanomedicine was elaborated and strategically equipped with a multiple of intriguing responsiveness. Particularly, core-shell plasmid DNA condensates were created based on polyionic complexation with block copolymer of polyethylene glycol (PEG)-polylysine (PLys), namely, the nanoscaled PLys&pDNA nanoparticle tethered with the biocompatible PEG surroundings. Furthermore, redox-reversible disulfide crosslinking was introduced into PLys&pDNA nanoparticle to accomplish adequate structural stabilities, and thermal-responsive polypropylacrylamide (PNIPAM) was introduced as the secondary intermediate surroundings onto the pre-formulated PLys&pDNA nanoparticle with the aim of preventing the potential enzymatic degradation from the environmental nucleases.

Positive role of plateau pika (Ochotona coronae) on environmental quality at low and moderate density on the Tibetan plateau: Evidence from a meta-analysis.

The roles of plateau pika (Ochotona coronae) in the Tibetan Plateau are often controversial, because it is often regarded as a destructive pest or an ecosystem engineer. Here a meta-analysis using 72 paired observations was conducted to examine whether the impacts of plateau pika on environmental quality (i.e.

Hybrid Brain-Computer Interface Controlled Soft Robotic Glove for Stroke Rehabilitation.

Soft robotic glove controlled by a brain-computer interface (BCI) have demonstrated effectiveness in hand rehabilitation for stroke patients. Current systems rely on static visual representations for patients to perform motor imagination (MI) tasks, resulting in lower BCI performance. Therefore, this study innovatively used MI and high-frequency steady-state visual evoked potential (SSVEP) to construct a friendly and natural hybrid BCI paradigm.

Improving SSVEP-BCI Performance Through Repetitive Anodal tDCS-Based Neuromodulation: Insights From Fractal EEG and Brain Functional Connectivity.

This study embarks on a comprehensive investigation of the effectiveness of repetitive transcranial direct current stimulation (tDCS)-based neuromodulation in augmenting steady-state visual evoked potential (SSVEP) brain-computer interfaces (BCIs), alongside exploring pertinent electroencephalography (EEG) biomarkers for assessing brain states and evaluating tDCS efficacy. EEG data were garnered across three distinct task modes (eyes open, eyes closed, and SSVEP stimulation) and two neuromodulation patterns (sham-tDCS and anodal-tDCS). Brain arousal and brain functional connectivity were measured by extracting features of fractal EEG and information flow gain, respectively.

A comprehensive study on the risk factors and pathogen analysis of postoperative wound infections following caesarean section procedures.

Postoperative wound infections (PWIs), a subtype of surgical site infections, are a significant concern for patients undergoing caesarean sections (C-sections). Understanding risk factors and pathogen profiles can greatly assist in early diagnosis and effective treatment. This study aimed to identify risk factors and analyse the pathogenic landscape contributing to PWIs in C-sections.

Regulated secretion of mutant p53 negatively affects T lymphocytes in the tumor microenvironment.

Several studies have demonstrated the role of the oncogenic mutant p53 in promoting tumor progression; however, there is limited information on the effects of secreted oncogenic mutant p53 on the tumor microenvironment and tumor immune escape. In this study, we found that secretion of mutant p53, determined by exosome content, is dependent on its N-terminal dileucine motif via its binding to β-adaptin, and inhibited by the CHK2-mediated-Ser 20 phosphorylation. Moreover, we observed that the mutant p53 caused downregulation and dysfunction of CD4 T lymphocytes in vivo and downregulated the levels and activities of rate-limiting glycolytic enzymes in vitro.

A High-Rate Hybrid BCI System Based on High-Frequency SSVEP and sEMG.

Recently, various biosignals have been combined with electroencephalography (EEG) to build hybrid brain-computer interface (BCI) systems to improve system performance. Since steady-state visual evoked potential (SSVEP) and surface electromyography (sEMG) are easy-to-use, non-invasive techniques, and have high signal-to-noise ratio (SNR), hybrid BCI systems combining SSVEP and sEMG have received much attention in the BCI literature. However, most existing studies regarding hybrid BCIs based on SSVEP and sEMG adopt low-frequency visual stimuli to induce SSVEPs.

A Calibration-Free Hybrid BCI Speller System Based on High-Frequency SSVEP and sEMG.

Hybrid brain-computer interface (hBCI) systems that combine steady-state visual evoked potential (SSVEP) and surface electromyography (sEMG) signals have attracted attention of researchers due to the advantage of exhibiting significantly improved system performance. However, almost all existing studies adopt low-frequency SSVEP to build hBCI. It produces much more visual fatigue than high-frequency SSVEP.

Downregulation of TCL6 protected human trophoblast cells from LPS-induced inflammation and ferroptosis.

Dysregulation of noncoding RNAs has been reported to have a close correlation with preeclampsia(PE)development. TCL6 was upregulated in patients with PE. In this study, we examined the impacts of TCL6 on modulating HTR-8/SVneo cells induced by LPS.

Identifying Intraoperative Spinal Cord Injury Location from Somatosensory Evoked Potentials' Time-Frequency Components.

Excessive distraction in corrective spine surgery can lead to iatrogenic distraction spinal cord injury. Diagnosis of the location of the spinal cord injury helps in early removal of the injury source. The time-frequency components of the somatosensory evoked potential have been reported to provide information on the location of spinal cord injury, but most studies have focused on contusion injuries of the cervical spine.

A High-Frequency SSVEP-BCI System Based on Simultaneous Modulation of Luminance and Motion Using Intermodulation Frequencies.

The low-frequency steady-state visual evoked potential (SSVEP)-based brain-computer interfaces (BCIs) tend to induce visual fatigue in the subjects. In order to enhance the comfort of SSVEP-BCIs, a novel SSVEP-BCI encoding method based on simultaneous modulation of luminance and motion is proposed. In this work, sixteen stimulus targets are simultaneously flickered and radially zoomed using a sampled sinusoidal stimulation method.

Construction of tea tree oil/salicylic acid/palygorskite hybrids for advanced antibacterial and anti-inflammatory performance.

This study describes the construction of a tailor-made clay-based hybrid with advanced dermocompatibility, antibacterial and anti-inflammatory performance by incorporating tunable ratios of tea tree oil (TTO) and salicylic acid (SA) into the naturally occurring porous structure of palygorskite (Pal). Among the three TTO/SA/Pal (TSP) systems constructed, TSP-1 with a TTO : SA ratio of 1 : 3 demonstrated the lowest 3T3 NRU predicted acute oral toxicity and dermal HaCaT cytotoxicity as well as the most pronounced antibacterial activity with a selective inhibitory action against the pathogens (, and ) over the beneficial () species inhabiting on the human skin. Also noticeable is that exposure of these skin commensal bacteria to TSP-1 prevented the antimicrobial resistance evolution compared to the conventional antibiotic ciprofloxacin.

Activation of pyroptosis by specific organelle-targeting photodynamic therapy to amplify immunogenic cell death for anti-tumor immunotherapy.

Pyroptosis, a unique lytic programmed cell death, inspired tempting implications as potent anti-tumor strategy in pertinent to its potentials in stimulating anti-tumor immunity for eradication of primary tumors and metastasis. Nonetheless, rare therapeutics have been reported to successfully stimulate pyroptosis. In view of the intimate participation of reactive oxygen species (ROS) in stimulating pyroptosis, we attempted to devise a spectrum of well-defined subcellular organelle (including mitochondria, lysosomes and endoplasmic reticulum)-targeting photosensitizers with the aim of precisely localizing ROS (produced from photosensitizers) at the subcellular compartments and explore their potentials in urging pyroptosis and immunogenic cell death (ICD).

Optimizing Stimulus Frequency Ranges for Building a High-Rate High Frequency SSVEP-BCI.

The brain-computer interfaces (BCIs) based on steady-state visual evoked potential (SSVEP) have been extensively explored due to their advantages in terms of high communication speed and smaller calibration time. The visual stimuli in the low- and medium-frequency ranges are adopted in most of the existing studies for eliciting SSVEPs. However, there is a need to further improve the comfort of these systems.

Transcranial Direct Current Stimulation-based Neuromodulation Improves the Performance of Brain-Computer Interfaces Based on Steady-State Visual Evoked Potential.

The study of brain state estimation and intervention methods is of great significance for the utility of brain-computer interfaces (BCIs). In this paper, a neuromodulation technology using transcranial direct current stimulation (tDCS) is explored to improve the performance of steady-state visual evoked potential (SSVEP)-based BCIs. The effects of pre-stimulation, sham-tDCS and anodal-tDCS are analyzed through a comparison of the EEG oscillations and fractal component characteristics.