Practical implementation of automated insulin delivery systems in 2025: A French position statement update.

The advent of automated insulin delivery (AID) systems in 2020 marked a disruptive event in managing type 1 diabetes, benefiting children and adults alike. By 2024, advances in real-world data and research motivated an update to the French consensus on AID systems to expand accessibility, refine guidelines, and optimize patient follow-up. AID systems have consistently improved glycemic control by reducing HbA1c, increasing time-in-range (TIR), and minimizing hypoglycemia, with significant benefits even for specific populations such as individuals with poor glycemic control, brittle diabetes, children, very young children, pregnant women, those with insulin resistance or gastroparesis, or after bariatric surgery.

Adaptable framework for cost-analyses in radiotherapy: Application to the cost of proton versus photon therapy for lung cancer in The Netherlands.

Background/purpose: Proton radiation-therapy (PrT) may provide clinical benefit for lung cancer compared to photon radiation-therapy (PhT), however is more costly. Literature reporting costs for PrT, PhT, and comparisons thereof, particularly from a societal perspective, are scarce. This study aims to provide an adaptable framework to estimate PrT/PhT costs, demonstrated through application to lung cancer, from societal and healthcare perspectives.

Characterizing diverse maize varieties under organic cultivation: phenotypic, yield, and canopy data from VIT Vellore.

Maize is an important food source standing first in production around the world. It has become an essential raw material in most of the food processing industries and is extensively cultivated for its post-harvest by-products. So, it is necessary to develop genotypes adapted to varied climate and soil conditions favoring its productivity.

Evaluating the efficacy of doripenem against Staphylococcus aureus in vancomycin-resistant strains.

Determination of antibiotic susceptibility is a crucial aspect of antimicrobial therapy. The objective of this study was to determine the specific susceptibility of Staphylococcus aureus (SA) to the antibiotic doripenem. A total of 180 clinical isolates from VRSA patients were tested against doripenem using minimum inhibitory concentration (MIC) and disk diffusion tests.

Embryonic Quality Assessment using Advanced Deep Learning Architectures utilizing Microscopic Images of Blastocysts.

The accurate evaluation of embryonic quality which is a key aspect in Assisted Reproductive Technology (ART) and it is crucial to ensure the success of in vitro fertilization (IVF), especially at critical developmental phases like day 3 and day 5. To increase the success rate of implantation, morphological feature-based scoring techniques are currently the mainstay of embryo evaluation. Addressing the need for enhanced accuracy and latency, our work uses advanced algorithms based on deep learning to assess microscopic images of embryos at these critical junctures.

Investigation of myocardial bioimpedance at multiple frequencies for cardiac radiofrequency ablation: ex-vivo experiments.

Background: Bioimpedance method is used clinically as a surrogate measure of effective tissue heating during cardiac ablation. It does not, however provide information regarding thermal cellular destruction which is the goal of ablation procedures.

Objective: This study investigated myocardial impedance (resistance and reactance) at different frequencies in response to the thermal effect and across temperatures where tissue necrosis occurs during ablation.

Effect of video-assisted educational intervention on improving knowledge, attitude and practice among mothers of children below five years on malnutrition: A systematic review.

Objectives: This review aimed to assess the effect of video-assisted educational interventions in enhancing knowledge, attitudes, and practices (KAP) among mothers of malnourished children aged <5 years.

Study Design: This was a systematic review.

Methods: A systematic search was conducted across PubMed, Scopus, and EMBASE databases from inception until November 2022.

Investigation of physical, structural, optical, and luminescence properties of nickel oxide doped alkali zinco-borate glasses.

Glasses having the stoichiometry ratio [(70-x) BO-10NaO-20ZnO-xNiO] where 0.0 ≤ x < 0.3 mol% were synthesized using a melt quenching technique.

Patient-Reported Outcomes of Dental Implants in Type 2 Diabetes: A Cross-Sectional Study on Quality of Life and Satisfaction.

Introduction: Dental implants provide a durable solution for missing teeth and improve mastication, speech, and quality of life (QoL). However, systemic conditions, such as type 2 diabetes mellitus (T2DM), may affect implant success. This study evaluated patient satisfaction (PS) and QoL as patient-reported outcome measures (PROMs) following dental implant therapy in T2DM patients.

Optimizing controlled degradation, bioactivity, and mechanical behavior in sol-gel synthesized aluminum titanate biomaterials.

Orthopaedic applications require materials that balance mechanical strength, biocompatibility, and controlled degradation, particularly for bone regeneration and load-bearing purposes. This study investigates the effects of varying weight percentages of AlOand TiO(25:75, 50:50, and 75:25) on the characteristics of AlTiObiomaterials synthesized via the sol-gel method. Structural and chemical characterizations, including XRD and FTIR, confirmed the successful synthesis of phase-pure AlTiO, highlighting functional groups such as Al-O and Ti-O.

Robust Prediction of Enzyme Variant Kinetics with RealKcat.

Accurate prediction of kinetic parameters is crucial for understanding known and tailoring novel enzymes for biocatalysis. Current models fail to capture mutation effects on catalytically essential residues, limiting their utility in enzyme design. We grid-searched through ten model architectures (25,671 hyperparameter combinations) to identify a gradient-based additive framework called RealKcat, trained on 27,176 experimental entries curated manually (KinHub-27k) by screening 2,158 articles.

Efficacy and safety of elobixibat in patients with chronic constipation-A randomized, multicenter, double-blind, placebo-controlled, parallel-group study from India.

Background: Elobixibat is a locally acting ileal bile acid transporter (IBAT) inhibitor that relieves functional constipation in patients by accelerating colonic transit. In this study, we aimed at determining the efficacy and safety of elobixibat for short-term treatment (two weeks) of chronic constipation in Indian patients.

Methods: The present study was a randomized, double-blind, parallel-group, placebo-controlled, phase III study to evaluate efficacy and safety of elobixibat.

Super-refractory Status Epilepticus and Cerebellar Involvement Following High-Voltage Electrical Injury.

Electrocution injuries can impact any organ or system in the body. The symptoms vary widely, from immediate cardiac arrest due to high-voltage current to mild discomfort caused by low-voltage current. There are four main types of electric injuries: flash, flame, lightning, and true direct injuries.

seeds capped calcium oxide nano particles - anti-microbial, antioxidant, anti-ulcer analysis.

Calcium Oxide (CaO) is the best replica of logically plentiful earth metal oxides. CaO nanoparticles include sphere-shaped or faceted elevated surface area and magnetic nanostructured particles. The current study give the information regarding booming synthesis of calcium oxide nanoparticles using calcium chloride as precursor and seed extract as capping agent.

Seasonal Trends and Antibiotic Resistance Profiles of Bacterial Pathogens in Indian Clinical Isolates.

Introduction Bacterial diseases exhibit seasonal trends, necessitating their monitoring for outbreak prediction, treatment optimization, and infection control. This study explores seasonal trends, temperature correlations, and antimicrobial resistance profiles of key pathogens in an Indian tertiary care setting. Methodology This cross-sectional study analyzed bacterial isolates from 1,562 patient samples, including , , , , , and .

Knowledge on birth control pills among married rural Indian women.

Despite the availability and benefits of birth control pills, rural areas in countries like India face challenges regarding contraceptive knowledge and utilization. Factors such as limited access to healthcare, cultural taboos, and educational barriers contribute to this issue. Addressing these gaps requires tailored reproductive health education and improved access to contraceptive services.

Stationary and libration motion in two coupled rotors: Theoretical and experimental study.

Coupled dynamics of camphor rotors exhibit a rich variety of transient and stationary state phenomena. Although previous attempts at modeling these dynamics have captured some of this richness, certain observed states like rotor libration remain elusive in the models. We suggest a Coulomb-Yukawa-type potential of the form 1-e^{-Kr^{n}}/r, with n>2, where K is the strength of coupling between two rotors and r is the distance between them.

Impact of Baseline Vision on Outcomes in Diabetic Macular Edema in VISTA/VIVID.

In VISTA/VIVID, although eyes with better baseline BCVA had lower visual gains at Week 100, they were more likely to achieve BCVA ≥ 70 letters and higher VFQ-25 scores than those with worse baseline BCVA.

Ensemble of feature augmented convolutional neural network and deep autoencoder for efficient detection of network attacks.

Network traffic must be monitored and analyzed for any abnormal activity in order to detect intrusions and to notify administrators of any attacks. A novel ensemble of deep learning technique is proposed to enhance the efficiency of Packet Flow Classification in Network Intrusion Detection System (NIDS). The proposed work consists of three phases: (i) Feature Augmented Convolutional Neural Network (FA-CNN) (ii) Deep Autoencoder (iii) Ensemble of FA-CNN and Deep Autoencoder.

Differential Expression of Hard Tissue Proteins in Hypomineralized Second Primary Molars in Comparison to Normal Teeth.

Objective: This study aims to identify the proteins in hypomineralized second primary molars (HSPMs) and correlate their function in Amelogenesis. HSPM is a qualitative defect of the enamel of the second primary molars with no clear etiology.

Material And Methods: Total protein quantification was performed using the Bradford Protein Assay, followed by the electrophoretic separation of samples using 2D-Gel electrophoresis to identify the proteins.

Corrigendum to "From prescription to pollution: The ecological consequences of NSAIDs in aquatic ecosystems" [Toxicol. Rep. 13 (2024) 101775].

[This corrects the article DOI: 10.1016/j.toxrep.

Patient-derived Organoids and Xenografts Uncover Therapeutic Vulnerabilities in Colorectal Signet Ring Cell Carcinomas.

Purpose: Identifying therapeutic targets for Signet Ring Cell Carcinoma (SRCC) of the colon and rectum is a clinical challenge due to the lack of Patient-Derived Organoids (PDO) or Xenografts (PDX). We present a robust method to establish PDO and PDX models to answer address this unmet need. We demonstrate that these models identify novel therapeutic strategies targeting therapy resistance and peritoneal metastasis.

Antioxidant, antidiabetic, and antimicrobial efficacy of germinated Ocimum gratissimum and Ocimum basilicum seed.

Background: The edible seeds of Ocimum gratissimum and Ocimum basilicum were found to be a potent source of phytochemicals with noteworthy antioxidant, antidiabetic, and antimicrobial properties. This study aimed to investigate the impact of germination and extraction solvents (ethanol (EtOH), distilled water) on the therapeutic properties exhibited and the ability of seed extracts to act as natural food preservatives.

Results: The EtOH extracts of germinated O.

The nucleolin antagonist N6L and paclitaxel combination treatment could be a new promising therapeutic strategy for pancreatic ductal adenocarcinoma therapy.

Pancreatic cancer (PCa) is one of the most devastating cancers with few clinical signs and no truly effective therapy. In recent years, our team has demonstrated that nucleolin antagonists such as N6L could be a therapeutic alternative for this disease. In order to study a possible clinic development of N6L (multivalent pseudopeptide), we undertook to study the effect of combination of N6L with chemotherapies classically used for PCa on the survival of pancreatic cancer cells.

3D modeling to predict vascular involvement in resectable pancreatic adenocarcinoma.

Background: Current management of patients with borderline resectable pancreatic adenocarcinoma (BR-PDAC) depends on the degree of involvement of the major arterial and venous structures. The aim of this study was to evaluate 3D segmentation and printing to predict tumor size and vascular involvement of BR-PDAC to improve pre-operative planning of vascular resection and better select patients for neoadjuvant therapy.

Methods: We retrospectively evaluated 16 patients with BR-PDAC near vascular structures who underwent pancreatoduodenectomy (PD) with or without vascular resection between 2015 and 2021.