Publications by authors named "Cuello Garcia Haider"
Donor-derived cell-free DNA-based liquid biopsies to determine future kidney transplant rejection.
Kidney Res Clin Pract
September 2024
Article Synopsis
- - Donor-derived cell-free DNA (dd-cfDNA) is being studied as a new way to detect kidney transplant rejection, showing potential links to rejection types like antibody-mediated rejection (ABMR) and T cell-mediated rejection (TCMR).
- - High levels of dd-cfDNA in the body fluids may signal transplant rejection due to immune system responses, providing more reliable and less invasive testing compared to traditional biopsies.
- - Specific dd-cfDNA concentration thresholds have been identified, like 2.45% for ABMR and 1.3% for TCMR, allowing doctors to assess rejection risk quickly, especially in emergencies, and suggesting the need for further research in this area.
The donor-derived cell-free DNA (ddcfDNA) is found in the plasma and urine of kidney transplant recipients and displays notable potential in diagnosing rejection, specifically antibody-mediated rejection (ABMR). Nonetheless, the quantitative methods of ddcfDNA lacking standardization and diverse detection techniques can impact the test outcomes. Besides, both the fraction and absolute values of ddcfDNA have been reported as valuable markers for rejection diagnosis, but they carry distinct meanings and are special in various pathological conditions.
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