Publications by authors named "Cuan Yang"
Article Synopsis
- Asprosin, a protein hormone linked to metabolic diseases, was found to affect the proliferation and migration of vascular smooth muscle cells (VSMCs) in a rat model of hypertension, indicating its potential role in cardiovascular diseases.
- The study showed that asprosin levels were higher in the VSMCs of hypertensive rats, and it promoted their proliferation and migration by increasing the activity of Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase and superoxide production.
- Knocking down asprosin reduced VSMC proliferation and migration, suggesting that targeting asprosin could help alleviate vascular remodeling and high blood pressure in hypertensive conditions.
Vascular endothelial growth factor and its receptor the kinase domain receptor play critical roles in the pathogenesis of coronary artery disease. Periostin is an up-regulator of kinase domain receptor expression. The purpose of this study was to determine whether polymorphisms in periostin are associated with the risk of coronary artery disease.
View Article and Find Full Text PDFAims: To determine the associations among periostin gene polymorphisms, clinical parameters and heart failure in a Chinese population.
Methods: In total, 464 patients with heart failure and 640 control individuals were included in this study. rs3829365 and rs1028728 were genotyped through PCR and restriction fragment length polymorphism.